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Calcineurin

A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
Also Known As:
Protein Phosphatase 3; Protein Phosphatase 3 Catalytic Subunit; Protein Phosphatase 3 Regulatory Subunit; Phosphatase 3, Protein; Protein Phosphatase 2B; Calcineurin A; Calcineurin B; Protein Phosphatase-2B
Networked: 1840 relevant articles (58 outcomes, 211 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Molkentin, Jeffery D: 52 articles (11/2015 - 03/2002)
2. Huang, Chih-Yang: 21 articles (07/2022 - 12/2005)
3. Rothermel, Beverly A: 20 articles (01/2021 - 08/2002)
4. Hill, Joseph A: 16 articles (01/2021 - 03/2002)
5. Minami, Takashi: 15 articles (08/2021 - 11/2004)
6. Kuo, Wei-Wen: 14 articles (02/2022 - 12/2005)
7. Molkentin, J D: 14 articles (12/2009 - 02/2000)
8. Heitman, Joseph: 13 articles (01/2020 - 10/2002)
9. Norris, Christopher M: 12 articles (01/2021 - 05/2005)
10. Frey, Norbert: 11 articles (10/2020 - 04/2002)

Related Diseases

1. Cardiomegaly (Heart Hypertrophy)
2. Hypertrophy
3. Ischemia
4. Heart Failure
5. Alzheimer Disease (Alzheimer's Disease)

Related Drugs and Biologics

1. Calcium
2. Tacrolimus (Prograf)
3. Phosphoric Monoester Hydrolases (Phosphatases)
4. Cyclosporine (Ciclosporin)
5. Calmodulin (Calcium-Dependent Activator Protein)
6. Phosphoprotein Phosphatases (Phosphatases, Protein)
7. Enzymes
8. Immunosuppressive Agents (Immunosuppressants)
9. Glucose (Dextrose)
10. Calcium-Calmodulin-Dependent Protein Kinase Type 2

Related Therapies and Procedures

1. Therapeutics
2. Hematopoietic Stem Cell Transplantation
3. Glycemic Control
4. Transplantation
5. Kidney Transplantation