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Thrombospondins

A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.
Also Known As:
Thrombospondin
Networked: 651 relevant articles (13 outcomes, 62 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Hill, Adrian V S: 12 articles (11/2014 - 04/2003)
2. Gilbert, Sarah C: 9 articles (11/2014 - 06/2003)
3. Bejon, Philip: 8 articles (05/2015 - 02/2005)
4. Edwards, Dylan R: 7 articles (02/2015 - 04/2004)
5. Nagase, Hideaki: 6 articles (11/2015 - 12/2004)
6. López-Otín, Carlos: 6 articles (05/2015 - 01/2002)
7. Wada, Hideo: 6 articles (11/2014 - 10/2004)
8. Frangogiannis, Nikolaos G: 6 articles (02/2014 - 06/2005)
9. Zheng, X Long: 6 articles (02/2014 - 06/2004)
10. Kazura, James W: 6 articles (05/2011 - 09/2004)

Related Diseases

1. Malaria
2. Neoplasms (Cancer)
3. Thrombotic Thrombocytopenic Purpura
4. Infection
5. Membranous Glomerulonephritis (Membranous Nephropathy)

Related Drugs and Biologics

1. Peptides
2. rituximab (Mabthera)
3. thymidine 5'-triphosphate (TTP)
4. Matrix Metalloproteinase 2 (Gelatinase A)
5. Proteins (Proteins, Gene)
6. Collagen
7. Endostatins
8. Antigens
9. Antineutrophil Cytoplasmic Antibodies (ANCA)
10. Peptide Hydrolases (Proteases)

Related Therapies and Procedures

1. Plasma Exchange
2. Angioplasty (Angioplasty, Transluminal)
3. Heterologous Transplantation (Xenotransplantation)
4. Traction
5. Splenectomy