|1.||Breast Neoplasms (Breast Cancer)
|4.||Sleep Initiation and Maintenance Disorders (Insomnia)
|5.||Prostatic Neoplasms (Prostate Cancer)
|1.||Loprinzi, Charles L: 35 articles (06/2015 - 03/2002)|
|2.||Barton, Debra L: 23 articles (06/2015 - 01/2002)|
|3.||Joffe, Hadine: 20 articles (06/2015 - 07/2006)|
|4.||Stearns, Vered: 20 articles (01/2011 - 04/2002)|
|5.||Freeman, Ellen W: 18 articles (12/2015 - 05/2005)|
|6.||Flaws, Jodi A: 18 articles (10/2015 - 06/2003)|
|7.||Carpenter, Janet S: 17 articles (07/2015 - 04/2002)|
|8.||Gallicchio, Lisa: 13 articles (10/2015 - 10/2005)|
|9.||Sammel, Mary D: 12 articles (12/2015 - 05/2005)|
|10.||Miller, Susan R: 11 articles (10/2015 - 10/2005)|
|1.||Estrogens (Estrogen)FDA Link
07/01/2011 - "Estrogen therapy is the most effective treatment for hot flashes. "
12/01/2008 - "For these women, estrogen therapy, the most effective treatment for hot flashes, should be considered. "
09/01/2008 - "Estrogen is the most effective treatment for management of hot flashes and night sweats. "
01/01/2007 - "Estrogen reliably reduces the severity of hot flashes and remain the single most effective treatment. "
01/01/2006 - "Short-term estrogen remains the most effective treatment for hot flashes, but because of safety concerns many women are reluctant to use this treatment. "
|2.||gabapentin (Neurontin)FDA LinkGeneric
03/01/2011 - "These adverse effects were most pronounced during the first 1-2 weeks of therapy, but resolved and were similar to those reported with placebo by week 4. These trials were short (<12 weeks) and had small sample sizes; however, their results appear to show that gabapentin is safe and effective for short-term treatment of hot flashes in women who have entered menopause either naturally or surgically. "
02/01/2009 - "Women assigned to gabapentin reported a significantly greater percent reduction in both the frequency of hot flashes (WMD = 23.72 [95% CI, 16.46-30.97]; P < 0.001) and the composite score (WMD = 27.26 [95% CI, 21.24-33.29]; P < 0.001), with significant between-study heterogeneity (I(2) = 97.8% and 95.6%, respectively). "
11/01/2012 - "Gabapentin is effective for hot flashes, and, therefore, may provide therapeutic benefit for both anxiety and hot flashes at a generic drug price. "
01/01/2010 - "Gabapentin is another nonhormonal agent that is effective in reducing hot flashes. "
01/01/2009 - "Although the studies were few, all showed gabapentin to be safe and effective in the treatment of hot flashes. "
|3.||venlafaxine (Effexor)FDA LinkGeneric
01/01/2007 - "Venlafaxine resulted in modest decreases in hot flashes, but only hot flash interference improved differentially at the higher dose. "
05/01/2003 - "Previous studies have defined that venlafaxine, an anti-depressant, is an effective treatment for such hot flashes. "
11/10/2013 - "In androgen-deprived men, neither venlafaxine nor soy proved effective in reducing hot flashes. "
11/01/2003 - "Venlafaxine is an effective nonhormonal alternative for relief from uncontrolled hot flashes."
01/01/2002 - "The data from this study provides evidence that venlafaxine has intermediate term efficacy and good tolerability as a treatment for hot flashes. "
|4.||Paroxetine (Paxil)FDA LinkGeneric
10/01/2004 - "The results from this trial suggest that paroxetine Is an effective agent for diminishing hot flashes in men receiving androgen ablation therapy."
05/01/2006 - "Is paroxetine an effective treatment for hot flashes?"
10/01/2005 - "Paroxetine is an effective treatment for hot flashes: results from a prospective randomized clinical trial."
10/01/2005 - "In an open-label trial we have previously demonstrated that paroxetine reduces hot flashes. "
06/01/2015 - "In PubMed, MeSH terms were used for paroxetine, menopause, and hot flashes. "
01/01/2015 - "Hormone therapy is the most effective treatment for sweating and hot flashes, which are the most common symptoms of the menopause. "
07/01/2004 - "Although alternatives exist, hormone therapy remains the most effective treatment for menopausal symptoms such as hot flashes, and it is the only treatment approved by the US Food and Drug Administration (FDA) for this indication. "
11/01/2009 - "Future studies should include measures of executive function and should address pressing clinical questions; including what formulation of combination hormone therapy is cognitively neutral/beneficial, yet effective in treating hot flashes in the early post-menopause."
06/01/2004 - "Third, people are already purchasing and using CAM modalities or are resuming hormone therapy for relief of hot flashes, and they and their clinicians are eager for and deserve more information on the safety and efficacy of these remedies."
01/01/2013 - "Valerian can be effective in treatment of menopausal hot flash and that it can be considered as a treatment of choice for reduction of hot flashes among the women who are reluctant to receive hormone therapy due to fear or any other reason. "
01/01/2009 - "SLC is effective in alleviating tamoxifen-induced hot flashes and improving the condition of sleep."
01/01/2013 - "Compared with tamoxifen, there is a reduced incidence of endometrial changes, thromboembolic events, and hot flashes. "
04/01/2008 - "At study entry, 864 (56%) of these women were taking tamoxifen, and hot flashes were reported by 674 (78%). "
04/01/2000 - "The data from this study can be utilized to better identify and educate women as to their probability of developing hot flashes after starting tamoxifen, to describe the average time frame for these hot flashes, and to predict the likelihood of whether resultant hot flashes will be substantial enough to have a woman request therapy for them."
01/01/2014 - "The ESR1 PvuII XbaI CG haplotype was associated with the time to the occurrence of hot flashes during the complete time on tamoxifen (CG/CG vs. CG/other + other/other: adjusted hazard ratio 0.49, 95 % CI 0.25-0.97; p = 0.04). "
|7.||Clonidine (ST 155)FDA LinkGeneric
01/01/2004 - "Oral and transdermal formulations of clonidine are moderately effective in reducing hot flashes. "
03/01/1987 - "A randomized prospective double-blind study was performed to evaluate the efficacy of a transdermal therapeutic system delivering clonidine in the treatment of menopausal hot flashes. "
07/01/2001 - "Clonidine reduces central sympathetic activation, widens the thermoneutral zone, and ameliorates hot flashes. "
11/01/1982 - "The effectiveness of clonidine in suppressing the occurrence of postmenopausal hot flashes was examined using a dose-response study design and objective recordings of hot flashes. "
05/01/2005 - "This narrowing may be due to elevated central noradrenergic activation, a contention supported by observations that clonidine and some relaxation procedures ameliorate hot flashes. "
|8.||Citalopram (Escitalopram)FDA Link
07/10/2010 - "Data for hot flash scores and frequencies showed significant improvement in hot flashes with citalopram over placebo, with no significant differences among doses. "
01/19/2011 - "Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial."
03/01/2013 - "Recurrence of VMS (frequency, severity, and bother) was measured with daily diaries for 3 weeks after cessation of escitalopram, which was administered to perimenopausal/postmenopausal women with hot flashes and night sweats in an 8-week randomized, placebo-controlled trial. "
12/01/2012 - "A double-blind, placebo-controlled randomized trial of escitalopram 10-20mg/day vs. identical placebo was conducted among 205 women ages 40-62 years with an average of ≥4 daily hot flashes recruited at 4 clinical sites from July 2009 to June 2010. "
08/01/2011 - "The aim of this study was to determine the effects of 10 and 20 mg/day of escitalopram on objectively recorded hot flashes and on the rectal temperature threshold for sweating. "
|9.||Antidepressive Agents (Antidepressants)IBA
01/01/2009 - "These data and subsequent study conclusions are evaluated and discussed in the context of other published trial data regarding the use of newer antidepressants for treating hot flashes. "
01/01/2009 - "Raw data from these two randomized, placebo-controlled trials evaluating second-generation antidepressants for hot flashes were obtained. "
01/01/2009 - "These two studies have repeatedly been put forward as evidence that newer antidepressants are not definitively proven to reduce hot flashes. "
12/19/2005 - "All 3 of these clinical trials demonstrated statistically significant reductions in hot flashes with these newer antidepressants compared with placebo. "
12/16/2000 - "Confirmation of the results of this 4-week study awaits the completion of three ongoing randomised studies to assess the effects of other related antidepressants for the treatment of hot flashes."
04/01/2015 - "This study aimed to quantitate the efficacy of soy isoflavones in the treatment of menopausal hot flashes. "
07/01/2000 - "Although some data seem to support the efficacy of isoflavones in reducing the incidence and severity of hot flashes, many studies have not found any difference between the isoflavone recipients and the controls. "
04/01/2015 - "Quantitative efficacy of soy isoflavones on menopausal hot flashes."
07/01/2012 - "This analysis was conducted to determine the efficacy of extracted or synthesized soybean isoflavones in the alleviation of hot flashes in perimenopausal and postmenopausal women. "
08/01/2014 - "Seventeen trials of isoflavones and amino acid effects on hot flashes and one additional symptom were identified. "
|1.||Hormone Replacement Therapy (Therapy, Hormone Replacement)
03/01/2003 - "Hormone replacement therapy successfully relieved or substantially decreased the hot flashes in all 8 patients treated. "
01/01/2015 - "Currently, hormone replacement therapy (HRT) is the only US Food and Drug Administration-approved treatment for hot flashes, resulting in clinical improvement in 80%-90% of symptomatic women. "
06/01/2015 - "At present, there is growing demand for alternative, or additional, treatments to hormone replacement therapy for menopause-related hot flashes (HF). "
09/01/2012 - "According to the results of this clinical trial, BRN-01 may be considered a new therapeutic option with a safe profile for hot flashes in menopausal women who do not want or are not able to take hormone replacement therapy or other recognized treatments for this indication. "
09/01/2012 - "Currently, hormone replacement therapy is the only approved treatment for hot flashes. "
|2.||Estrogen Replacement Therapy
01/01/2013 - "This article discusses the superior efficacy of the newer nonhormonal prescriptions for the treatment of hot flashes when compared with estrogen replacement therapy, and provides some recommendations regarding use of them in peri- and postmenopausal women."
11/01/2000 - "A few studies reveal a minimal effect of soy on hot flashes, with soy reducing hot flashes 45% and placebo causing a 30% reduction compared with an approximate 70% reduction in hot flashes with estrogen replacement therapy. "
06/01/2014 - "Concerned about the safety of conventional estrogen replacement therapy, women are using botanical dietary supplements as alternatives for the management of menopausal symptoms such as hot flashes. "
12/01/2008 - "Estrogen replacement therapy alleviates the number and severity of hot flashes but is contraindicated in such cases. "
07/01/1997 - "Knowledge of the nature of these disease processes is necessary for quick recognition of patients with hot flashes who do not respond to estrogen replacement treatment, and to facilitate the proper evaluation of atypical patients."
07/01/2004 - "We conclude that hypnosis is a mind-body intervention that may be of significant benefit in treatment of hot flashes and other benefits may include reduced anxiety and improved sleep. "
01/01/2013 - "Based on the authors' previous research, the present study was developed to evaluate the feasibility of a guided self-hypnosis intervention for hot flashes. "
01/01/2011 - "The present study will compare hypnosis to a structured-attention control in reducing hot flashes (perceived and physiologically monitored) in post-menopausal women in a randomized clinical trial. "
01/01/2011 - "Hypnosis for hot flashes among postmenopausal women study: a study protocol of an ongoing randomized clinical trial."
11/01/2008 - "On the basis of previous case studies, this study was developed to evaluate the effect of a hypnosis intervention for hot flashes. "
01/01/2008 - "Nine trials evaluated the efficacy of relaxation techniques to improve hot flashes. "
01/01/2014 - "The intervention involved 7 weekly sessions of hypnotic relaxation therapy directed toward alleviation of hot flashes. "
03/01/2005 - "Exercise has been shown to help some women with symptoms of hot flashes, as have relaxation techniques and deep breathing. "
01/01/2014 - "At week 12, both self-reported and physiologically measured hot flashes decreased 95% and sleep quality improved 37.5% over baseline, suggesting hypnotic relaxation therapy may be an effective intervention for men with hot flashes following treatment for prostate cancer."
01/01/2015 - "Hypnotic relaxation therapy (HRT) has been shown to reduce hot flashes in postmenopausal women and breast cancer survivors. "
12/01/2002 - "Improvement in the hot flashes remained for months after discontinuing the injections in many patients. "
12/01/2002 - "A review of hot flash diaries and patient charts were completed to evaluate the effectiveness and tolerability of these injections for managing hot flashes. "
06/01/2002 - "depot MPA injections provides significant and long-lasting relief from postmenopausal hot flashes in patients with a history of breast cancer, offering an alternative to estrogen replacement therapy or prolonged administration of oral megestrol."
03/01/1999 - "After combinations of estrogen in tablets and patches failed to relieve my hot flashes, my doctor tried monthly estrogen injections. "
03/01/1983 - "To examine the relationship between the occurrence of menopausal hot flashes and the pulsatile release of LH, we have investigated the serum hormone levels and the occurrence of hot flashes by objective recordings in five women with endometriosis given daily injections of a long-acting GnRH agonist (GnRH-a) for 28 days. "