Multiple System Atrophy

A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
Also Known As:
Multiple System Atrophy Syndrome; Multisystem Atrophy; Multisystemic Atrophy; Atrophies, Multisystem; Atrophies, Multisystemic; Atrophy, Multiple System; Atrophy, Multisystem; Atrophy, Multisystemic; Multiple System Atrophies; Multisystem Atrophies; Multisystemic Atrophies
Networked: 1045 relevant articles (17 outcomes, 104 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Parkinson Disease (Parkinson's Disease)
2. Orthostatic Hypotension (Postural Hypotension)
3. Overactive Urinary Bladder (Overactive Bladder)
4. Atrophy
5. Parkinsonian Disorders (Parkinsonism)


1. Wenning, Gregor K: 41 articles (01/2016 - 09/2002)
2. Poewe, Werner: 34 articles (10/2015 - 09/2002)
3. Stefanova, Nadia: 28 articles (01/2016 - 09/2002)
4. Goldstein, David S: 25 articles (11/2015 - 07/2002)
5. Masliah, Eliezer: 19 articles (01/2015 - 06/2002)
6. Wakabayashi, Koichi: 18 articles (12/2015 - 02/2002)
7. Rockenstein, Edward: 18 articles (01/2015 - 06/2002)
8. Takahashi, Hitoshi: 16 articles (12/2015 - 03/2002)
9. Mori, Fumiaki: 15 articles (12/2015 - 03/2002)
10. Holmes, Courtney: 15 articles (11/2015 - 08/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Multiple System Atrophy:
1. Levodopa (L Dopa)FDA LinkGeneric
2. alpha-SynucleinIBA
3. 3-Iodobenzylguanidine (Iobenguane)IBA
4. Rifampin (Rifampicin)FDA LinkGeneric
5. Minocycline (Cyclops)FDA LinkGeneric
6. rasagiline (Azilect)FDA Link
7. Type A Botulinum Toxins (Botulinum A Toxin)FDA Link
8. CamptocormiaIBA
9. Dopamine beta-HydroxylaseIBA
07/15/2003 - "Variations in the dopamine beta-hydroxylase gene are not associated with the autonomic disorders, pure autonomic failure, or multiple system atrophy."
07/15/2003 - "Recent findings of an association between human NE deficiency and variants at the dopamine beta-hydroxylase (DBH) gene [Kim et al., 2002] prompted us to investigate these markers in patients with autonomic disorders; 38 with orthostatic intolerance (OI), 26 with pure autonomic failure (PAF), and 39 with multiple system atrophy (MSA). "
08/01/1991 - "The effect of a balanced liquid meal on supine and postural blood pressure (BP) responses was investigated in three groups of patients with chronic autonomic failure; 10 with associated neurological impairment (multiple system atrophy (MSA), Shy-Drager syndrome) and seven without (of which five had pure autonomic failure (PAF); and two had a deficiency of the enzyme dopamine beta hydroxylase, DBH-deficiency). "
01/01/2006 - "DOPS improved orthostatic hypotension in patients with familial amyloid polyneuropathy, congenital deficiency of dopamine beta hydroxylase, pure autonomic failure and multiple system atrophy. "
04/01/1995 - "The effect of supine exercise on blood pressure (BP), measured while recumbent and after head-up postural change, was investigated in three groups with marked postural hypotension due to chronic autonomic failure: 15 with associated neurological impairment (Shy-Drager syndrome, SDS, multiple system atrophy); 15 with pure autonomic failure (PAF) and two with a deficiency of the enzyme dopamine beta hydroxylase (DBH deficiency). "
10. Trimethaphan (Trimetaphan)IBA

Therapies and Procedures

1. Continuous Positive Airway Pressure
2. Deep Brain Stimulation
3. Transplants (Transplant)
4. Cell Transplantation
5. Denervation