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Multiple System Atrophy

A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
Also Known As:
Multiple System Atrophy Syndrome; Multisystem Atrophy; Multisystemic Atrophy; Atrophies, Multisystem; Atrophies, Multisystemic; Atrophy, Multiple System; Atrophy, Multisystem; Atrophy, Multisystemic; Multiple System Atrophies; Multisystem Atrophies; Multisystemic Atrophies
Networked: 1925 relevant articles (40 outcomes, 202 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Parkinson Disease (Parkinson's Disease)
2. Orthostatic Hypotension (Postural Hypotension)
3. Parkinsonian Disorders (Parkinsonism)
4. Pure Autonomic Failure
5. Synucleinopathies

Experts

1. Wenning, Gregor K: 71 articles (01/2022 - 08/2003)
2. Stefanova, Nadia: 55 articles (02/2022 - 08/2003)
3. Poewe, Werner: 50 articles (01/2022 - 08/2003)
4. Goldstein, David S: 36 articles (01/2021 - 07/2002)
5. Masliah, Eliezer: 33 articles (10/2020 - 06/2002)
6. Wakabayashi, Koichi: 27 articles (04/2022 - 02/2002)
7. Hasegawa, Masato: 25 articles (01/2022 - 05/2002)
8. Meissner, Wassilios G: 24 articles (01/2022 - 01/2013)
9. Mori, Fumiaki: 23 articles (04/2022 - 03/2002)
10. Rockenstein, Edward: 23 articles (01/2020 - 06/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Multiple System Atrophy:
1. SynucleinsIBA
2. alpha-SynucleinIBA
3. Levodopa (L Dopa)FDA LinkGeneric
4. Dopamine (Intropin)FDA LinkGeneric
5. DroxidopaIBA
6. GliadinIBA
7. Biomarkers (Surrogate Marker)IBA
8. 3-Iodobenzylguanidine (Iobenguane)IBA
9. Amantadine (Aman)FDA LinkGeneric
10. rasagiline (Azilect)FDA Link

Therapies and Procedures

1. Therapeutics
2. Immunotherapy
3. Transplantation
4. Punctures
5. Aftercare (After-Treatment)