Arrhythmogenic Right Ventricular Dysplasia (Arrhythmogenic Right Ventricular Cardiomyopathy)

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124 relevant articles (2 outcomes, 9 trials/studies) found for this Disease

Description: A congenital cardiomyopathy that is characterized by infiltration of adipose and fibrous tissue into the RIGHT VENTRICLE wall and loss of myocardial cells. Primary injuries usually are at the free wall of right ventricular and right ATRIA resulting in ventricular and supraventricular arrhythmias.

Also Known As:

Arrhythmogenic Right Ventricular Cardiomyopathy; Right Ventricular Dysplasia, Arrhythmogenic; Ventricular Dysplasia, Right, Arrhythmogenic

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 18533

Heart Diseases: 12360

Cardiomyopathies: 6570

Arrhythmogenic Right Ventricular Dysplasia: 124

Congenital Heart Defects: 687

Arrhythmogenic Right Ventricular Dysplasia: 124

Cardiovascular Abnormalities: 167

Congenital Heart Defects: 687

Arrhythmogenic Right Ventricular Dysplasia: 124

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 422

Congenital Abnormalities: 9333

Cardiovascular Abnormalities: 167

Congenital Heart Defects: 687

Arrhythmogenic Right Ventricular Dysplasia: 124

Related Diseases

1.	Ventricular Tachycardia
2.	Myocardial Infarction
3.	Myocarditis (Carditis)
4.	Cardiomyopathies (Cardiomyopathy)
5.	Dilated Cardiomyopathy (Cardiomyopathy, Congestive)

Experts

1.	McKenna, William J: 6 articles (11/2007 - 03/2004)
2.	Wichter, Thomas: 5 articles (11/2007 - 03/2004)
3.	Thiene, Gaetano: 5 articles (08/2005 - 11/2002)
4.	Basso, Cristina: 5 articles (08/2005 - 11/2002)
5.	Saffitz, Jeffrey E: 3 articles (11/2007 - 05/2004)
6.	Syrris, Petros: 3 articles (11/2007 - 08/2005)
7.	Meurs, Kathryn M: 3 articles (05/2007 - 12/2005)
8.	Breithardt, Günter: 3 articles (10/2006 - 03/2004)
9.	Calkins, Hugh: 3 articles (09/2006 - 05/2004)
10.	Protonotarios, Nikos: 3 articles (09/2006 - 03/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Arrhythmogenic Right Ventricular Dysplasia:

1.	CatecholaminesIBA 02/01/1994 - "BACKGROUND: In patients with arrhythmogenic right ventricular cardiomyopathy (ARVC), the frequent provocation of ventricular tachycardia during exercise, the sensitivity toward catecholamines, and the response toward antiarrhythmic drug regimen with antiadrenergic properties suggest an involvement of the sympathetic nervous system in arrhythmogenesis" 04/04/2000 - "BACKGROUND: The frequent provocation of ventricular tachycardia by stress or catecholamines and the efficacy of antiarrhythmic drugs with antiadrenergic properties suggest an involvement of the cardiac adrenergic system in arrhythmogenesis in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC)" Order ALL the reference details at left...
2.	Anti-Arrhythmia AgentsIBA 04/04/2000 - "BACKGROUND: The frequent provocation of ventricular tachycardia by stress or catecholamines and the efficacy of antiarrhythmic drugs with antiadrenergic properties suggest an involvement of the cardiac adrenergic system in arrhythmogenesis in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC)" Order ALL the reference details at left...
3.	carvedilol (Coreg)FDA LinkGeneric 01/01/2004 - "Carvedilol therapy improved left ventricular function in a patient with arrhythmogenic right ventricular cardiomyopathy." Order ALL the reference details at left...
4.	Desmoplakins (Desmoplakin)IBA 08/01/2005 - "Desmoplakin disease in arrhythmogenic right ventricular cardiomyopathy: early genotype-phenotype studies." 08/01/2005 - "AIMS: To characterize the clinical profile of patients belonging to families affected with autosomal dominant arrhythmogenic right ventricular cardiomyopathy (ARVC) due to mutations of the gene encoding for the cell-to-cell adhesion protein desmoplakin (DSP)" 08/01/2005 - "Clinical profile of four families with arrhythmogenic right ventricular cardiomyopathy caused by dominant desmoplakin mutations." 07/16/2003 - "A recessive mutation in desmoplakin causes arrhythmogenic right ventricular dysplasia, skin disorder, and woolly hair." 09/15/2006 - "Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy." Order ALL the reference details at left...
5.	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 03/01/1999 - "In the present study, 45 explanted hearts from patients who underwent orthotopic heart transplant at University of Padova were studied by reverse transcriptase (RT)-polymerase chain reaction (PCR): 27 patients had dilated cardiomyopathy (DC), 12 had ischemic cardiopathy (IC), 2 had valvular disease (VD), 2 had arrhythmogenic right ventricular cardiomyopathy (ARVC), 1 had giant cell myocarditis (GCM), and 1 had lymphocytic myocarditis (LM)" Order ALL the reference details at left...
6.	Ergonovine (Ergometrine)IBA 01/01/1991 - "Underlying diseases included old myocardial infarction (OMI) with aneurysm (An) in 6 patients, variant angina, arrhythmogenic right ventricular dysplasia, Romano-Ward syndrome, complete atrioventricular block in one each, and diseases of unknown etiology in 2. Ergonovine-provocative coronary angiography (CAG) was performed in 3 patients, and EPS including ventricular tachycardia study was performed in 7. Coronary artery spasm was induced in one patient during CAG; sustained monomorphic ventricular tachycardia in 4 patients; and repetitive ventricular response in 2 of 7 patients examined by EPS" Order ALL the reference details at left...
7.	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 06/01/2008 - "Two single-nucleotide polymorphisms in the type 2 ryanodine receptor (RyR2) leading to the nonsynonymous amino acid replacements G1885E and G1886S are associated with arrhythmogenic right ventricular cardiomyopathy in patients who are carrying both of the corresponding RyR2 alleles" 08/08/2006 - "Histologic analysis of hearts from RyR2(R176Q/+) mice revealed no evidence of fibrofatty infiltration or structural abnormalities characteristic of arrhythmogenic right ventricular dysplasia, but right ventricular end-diastolic volume was decreased in RyR2(R176Q/+) mice compared with controls, indicating subtle functional impairment due to the presence of a single mutant allele" 08/01/2006 - "OBJECTIVE: Mutations in the cardiac ryanodine receptor (RYR2) gene have been reported to cause arrhythmogenic right ventricular cardiomyopathy (ARVC)" 08/01/2006 - "Composite polymorphisms in the ryanodine receptor 2 gene associated with arrhythmogenic right ventricular cardiomyopathy." 08/01/2006 - "Differential expression of the cardiac ryanodine receptor in normal and arrhythmogenic right ventricular cardiomyopathy canine hearts." Order ALL the reference details at left...
8.	gamma Catenin (Plakoglobin)IBA 11/01/2007 - "A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy." 10/24/2006 - "Age- and training-dependent development of arrhythmogenic right ventricular cardiomyopathy in heterozygous plakoglobin-deficient mice." 09/01/2006 - "Arrhythmogenic right ventricular cardiomyopathy caused by deletions in plakophilin-2 and plakoglobin (Naxos disease) in families from Greece and Cyprus: genotype-phenotype relations, diagnostic features and prognosis." 05/01/2004 - "Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease)." 02/01/2002 - "Arrhythmogenic right ventricular cardiomyopathy caused by a deletion in plakoglobin (Naxos disease)." Order ALL the reference details at left...
9.	Proteins (Proteins, Gene)IBA 09/28/2007 - "The results are discussed in the context of arrhythmogenic right ventricular cardiomyopathy, an inherited disease involving mutations in desmosomal proteins, including PKP2." 01/01/2006 - "There have also been important new breakthroughs in the genetic basis of arrhythmogenic right-ventricular dysplasia; it now appears that most forms result from mutations in genes encoding desmosomal junction proteins" 05/01/2007 - "Mutations in genes encoding desmosomal proteins such as PKP2, DSP, JUP, DSC2 and DSG2 underlie arrhythmogenic right ventricular cardiomyopathy, which can therefore be considered a desmosome cardiomyopathy" 01/01/2007 - "BACKGROUND: Mutations in genes encoding desmosomal proteins have been reported to cause arrhythmogenic right ventricular cardiomyopathy (ARVC), an autosomal dominant disease characterised by progressive myocardial atrophy with fibro-fatty replacement" 07/01/2006 - "Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is a genetic disease caused by mutations in desmosomal proteins" Order ALL the reference details at left...
10.	Amiodarone (Amiodarona)FDA LinkGeneric 05/01/2002 - "Amiodarone distribution in human tissues after long-term therapy: a case of arrhythmogenic right ventricular cardiomyopathy." 04/01/1997 - "We describe a patient who was treated with amiodarone for ventricular arrhythmia based on arrhythmogenic right ventricular dysplasia and who subsequently developed severe amiodarone-induced thyrotoxicosis" 05/01/2002 - "The tissue distribution of amiodarone and desethylamiodarone, its active metabolite, was examined in an autopsied case, an 85-year-old man, with arrhythmogenic right ventricular cardiomyopathy (ARVC) who had been receiving amiodarone for 4 years" 12/01/1998 - "Among 12 thyrotoxic patients, a patient with arrhythmogenic right ventricular dysplasia, who had been taking amiodarone for 4 years, developed thyrotoxicosis with subacute onset, accompanied by transiently positive thyrotropin (TSH) receptor antibody (TRAb), or thyrotropin-binding inhibiting immunoglobulin (TBII)" Order ALL the reference details at left...

Therapies and Procedures

1.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 05/01/2007 - "The aim of the present study was to investigate outcomes of implantable cardioverter-defibrillator (ICD) treatment in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC)" 01/01/2006 - "Other studies have demonstrated the important role of implantable cardioverter defibrillator therapy in the management of patients with arrhythmogenic right-ventricular dysplasia" 09/01/2006 - "The use of an implantable cardioverter defibrillator in a Boxer Dog to control clinical signs of arrhythmogenic right ventricular cardiomyopathy." 11/01/2005 - "Predictors of appropriate implantable defibrillator therapies in patients with arrhythmogenic right ventricular dysplasia." 08/01/2005 - "Arrhythmogenic right ventricular cardiomyopathy with implantable cardioverter defibrillator placement in pregnancy." Order ALL the reference details at left...
2.	Defibrillators (Defibrillator) 05/01/2007 - "The finding of right ventricular fat must be interpreted cautiously to avoid the pharmacologic and defibrillator intervention associated with management of arrhythmogenic right ventricular dysplasia." 05/01/2007 - "Outcome of cardioverter-defibrillator implant in patients with arrhythmogenic right ventricular cardiomyopathy." 02/14/2003 - "Arrhythmogenic right ventricular dysplasia was suspected, and a cardioverter defibrillator (ICD) was implanted" 11/01/1990 - "A 30 year-old male patient with arrhythmogenic right ventricular dysplasia was submitted to implantation an automatic cardioverter-defibrillator" 01/01/2007 - "Extraction of electrode of implanted cardioverter-defibrillator with the help of excimer laser in a patient with arrhythmogenic right ventricular dysplasia]" Order ALL the reference details at left...
3.	Heart Transplantation (Grafting, Heart) 12/01/2005 - "Three cases of orthotopic heart transplantation for arrhythmogenic right ventricular cardiomyopathy." 02/01/2005 - "Arrhythmogenic right ventricular dysplasia: catheter ablation, MRI, and heart transplantation." 01/01/2008 - "She presented with an unusual clinical course for arrhythmogenic right ventricular cardiomyopathy, which was complicated by progressive congestive heart failure and ultimately required heart transplantation" 09/01/2007 - "Resolution of protein-losing enteropathy after successful heart transplantation in an adult patient with arrhythmogenic right ventricular cardiomyopathy (ARVC)." 01/01/2004 - "However, during the last decade this view has been challenged by several studies demonstrating that a significant number of cardiac myocytes undergo apoptosis in myocardial infarction, heart failure, myocarditis, arrhythmogenic right ventricular dysplasia, and immune rejection after cardiac transplantation, as well as in other conditions of stress" Order ALL the reference details at left...
4.	Transplants (Transplant) 11/01/2006 - "Post-transplant arrhythmogenic right ventricular cardiomyopathy diagnosis was made in 6 patients with a pre-transplant diagnosis of IDC or KaShan disease" 03/01/2007 - "Remodeling has been associated with such diseases as pulmonary hypertension, lung transplant, LV pathology, Chagas' disease, and arrhythmogenic right ventricular cardiomyopathy" 06/01/2006 - "A 27-year-old man who was diagnosed with arrhythmogenic right ventricular dysplasia (ARVD) underwent the total right ventricular (RV) exclusion procedure: the RV free wall was resected and an extracardiac total cavopulmonary connection (TCPC) was created using a 24-mm-diameter polytetrafluoroethylene (PTFE) graft" 03/01/1999 - "In the present study, 45 explanted hearts from patients who underwent orthotopic heart transplant at University of Padova were studied by reverse transcriptase (RT)-polymerase chain reaction (PCR): 27 patients had dilated cardiomyopathy (DC), 12 had ischemic cardiopathy (IC), 2 had valvular disease (VD), 2 had arrhythmogenic right ventricular cardiomyopathy (ARVC), 1 had giant cell myocarditis (GCM), and 1 had lymphocytic myocarditis (LM)" Order ALL the reference details at left...
5.	Electrodes (Electrode) 11/01/2001 - "The right ventricular outflow tract as an unusual location for an implantable defibrillator electrode in a patient with arrhythmogenic right ventricular dysplasia." 01/01/2007 - "Extraction of electrode of implanted cardioverter-defibrillator with the help of excimer laser in a patient with arrhythmogenic right ventricular dysplasia]" 11/01/2001 - "A 41-year-old woman with arrhythmogenic right ventricular dysplasia (ARVD) underwent the implantation of an implantable cardioverter-defibrillator (ICD), in which the defibrillator electrode was unusually located in the right ventricular (RV) outflow tract" 01/01/1990 - "Electrode catheter ablation of resistant ventricular tachycardia in arrhythmogenic right ventricular dysplasia: experience of 15 patients with a mean follow-up of 45 months." 09/01/1989 - "Electrode catheter ablation of resistant ventricular tachycardia in arrhythmogenic right ventricular dysplasia: experience of 13 patients with a mean follow-up of 45 months." Order ALL the reference details at left...

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