|1.||Sánchez, Elda E: 6 articles (01/2015 - 04/2006)|
|2.||Lucena, Sara E: 5 articles (01/2015 - 09/2010)|
|3.||Soto, Julio G: 4 articles (07/2012 - 04/2006)|
|4.||Marcinkiewicz, Cezary: 4 articles (07/2012 - 01/2007)|
|5.||Lucena, Sara: 3 articles (01/2015 - 03/2009)|
|6.||Perez, John C: 3 articles (01/2015 - 12/2004)|
|7.||Suntravat, Montamas: 3 articles (01/2015 - 02/2014)|
|8.||Sanchez, Elda E: 3 articles (02/2012 - 12/2004)|
|9.||Markland, Francis S: 3 articles (01/2010 - 12/2002)|
|10.||Calvete, Juan J: 2 articles (12/2014 - 01/2007)|
|1.||Retinal Detachment (Retinal Detachments)
04/01/1996 - "This study was performed to determine whether disintegrins were effective in inhibiting RPE cell-induced matrix attachment in vitro and tractional retinal detachment in a rabbit model in vivo. "
04/01/1996 - "In the in vivo model, rabbit eyes were injected intravitreously with either homologous rabbit RPE cells alone or together with disintegrins to induce tractional retinal detachment. "
04/01/1996 - "Inhibition of retinal pigment epithelial cell-induced tractional retinal detachment by disintegrins, a group of Arg-Gly-Asp-containing peptides from viper venom."
|2.||Melanoma (Melanoma, Malignant)
01/01/1995 - "Effect of four disintegrins on the adhesive and metastatic properties of B16F10 melanoma cells in a murine model."
12/15/2007 - "When injected simultaneously with melanoma cells in mice, the three disintegrins significantly reduced tumor lung colonization. "
12/15/2007 - "Effect of RGD-disintegrins on melanoma cell growth and metastasis: involvement of the actin cytoskeleton, FAK and c-Fos."
01/01/1995 - "This antibody bound to B16F10 melanoma cells in suspension and inhibited binding of fluorescein isothiocyanate (FITC)-labeled disintegrins to these cells, being the most effective with FITC-labeled albolabrin. "
01/01/1995 - "Four disintegrins, eristostatin, albolabrin, barbourin and echistatin, injected IV into C57BL/6 mice in combination with B16F10 murine melanoma cells, inhibited formation of experimental lung metastases with ID50s of 0.05, 1.0, 0.9, and 3.7 mumoles per mouse, respectively. "
01/01/2007 - "We will summarize the major findings from studies using disintegrins to target integrin-associated angiogenesis in cancer models. "
02/01/2014 - "Both recombinant disintegrins bind to α(v)β₃ and α(v)β₅ receptors that are upregulated in tumor endothelial cells, having a higher binding activity to α(v)β₃ integrin."
07/01/2012 - "Therefore, the molecular basis of these disintegrins may be useful for developing new angiostatic pharmaceuticals for application in cancer therapy."
03/15/2012 - "The therapeutic modulation of multiple integrin pathways via soluble disintegrins was previously shown by us and others to elicit potent anti-angiogenic and anti-metastatic effects in several animal cancer models. "
02/01/2012 - "As a consequence, disintegrins can inhibit platelet aggregation and inhibit cell migration, proliferation, and initiate apoptosis in cancer cell lines. "
01/01/2015 - "In this study, we summarize the activity of two integrins antagonist, recombinant disintegrins mojastin 1 and viridistatin 2, on human pancreatic carcinoma cell line (BXPC-3). "
01/01/2003 - "Taken together, these results suggest that complex interactions between integrins, disintegrins, matrix metalloproteinases, and tissue inhibitors of matrix metalloproteinases may mediate ovarian carcinoma cell invasion, and that the dye-based assay described herein is a suitable model system for its study."
01/01/2003 - "Differential gene expression of matrix metalloproteinases, tissue inhibitors of matrix metalloproteinases, and disintegrins were observed in primary ovarian carcinoma tumors and secondary metastases, compared to normal ovaries. "
04/01/2006 - "The disintegrins from the Mohave rattlesnake venom were able to inhibit ADP-induced platelet aggregation in whole human blood both having IC50s of 13.8 nM, but were not effective in inhibiting the binding of human urinary bladder carcinoma cells (T24) to fibronectin."
06/01/2005 - "In this study, three structurally distinct disintegrins (flavoridin, echistatin, kistrin) were used as molecular probes to further characterize the molecular mechanisms underlying Yersinia enterocolitica infection of host cells. "
08/01/2004 - "Lentiviral infection induced microglial and macrophage expression of two disintegrins and metalloproteinases with thrombospondin motifs (ADAMTS-1 and ADAMTS-4), with high substrate specificity for matrix proteoglycans. "
|6.||Snake Venoms (Snake Venom)
|8.||Viper Venoms (Viper Venom)
|9.||Proteins (Proteins, Gene)