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Disintegrins

A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.
Networked: 48 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Sánchez, Elda E: 6 articles (01/2015 - 04/2006)
2. Lucena, Sara E: 5 articles (01/2015 - 09/2010)
3. Soto, Julio G: 4 articles (07/2012 - 04/2006)
4. Marcinkiewicz, Cezary: 4 articles (07/2012 - 01/2007)
5. Lucena, Sara: 3 articles (01/2015 - 03/2009)
6. Perez, John C: 3 articles (01/2015 - 12/2004)
7. Suntravat, Montamas: 3 articles (01/2015 - 02/2014)
8. Sanchez, Elda E: 3 articles (02/2012 - 12/2004)
9. Markland, Francis S: 3 articles (01/2010 - 12/2002)
10. Calvete, Juan J: 2 articles (12/2014 - 01/2007)

Related Diseases

1. Retinal Detachment (Retinal Detachments)
2. Melanoma (Melanoma, Malignant)
3. Neoplasms (Cancer)
4. Carcinoma (Carcinomatosis)
5. Infection

Related Drugs and Biologics

1. Fluorescein-5-isothiocyanate (FITC)
2. Fluorescein (Funduscein)
3. albolabrin
4. isothiocyanic acid
5. Integrins
6. Snake Venoms (Snake Venom)
7. Matrix Metalloproteinases
8. Viper Venoms (Viper Venom)
9. Proteins (Proteins, Gene)
10. echistatin

Related Therapies and Procedures

1. Therapeutics