Camphor 5-Monooxygenase (Camphor 5 Monooxygenase)

A soluble cytochrome P-450 enzyme that catalyzes camphor monooxygenation in the presence of putidaredoxin, putidaredoxin reductase, and molecular oxygen. This enzyme, encoded by the CAMC gene also known as CYP101, has been crystallized from bacteria and the structure is well defined. Under anaerobic conditions, this enzyme reduces the polyhalogenated compounds bound at the camphor-binding site.

Also Known As:

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Baudry, Jerome: 1 article (04/2016)
2.	McCammon, J Andrew: 1 article (04/2016)
3.	Miao, Yinglong: 1 article (04/2016)
4.	Smith, Jeremy C: 1 article (04/2016)
5.	Makris, Thomas M: 1 article (12/2007)
6.	Schlichting, Ilme: 1 article (12/2007)
7.	Sligar, Stephen G: 1 article (12/2007)
8.	von Koenig, Konstanze: 1 article (12/2007)

Related Diseases

1.	Substance-Related Disorders (Drug Abuse) 04/01/2016 - "Dihedral conformational transitions are analyzed systematically in a model globular protein, cytochrome P450cam, to examine their structural and chemical dependences through combined conventional molecular dynamics (cMD), accelerated molecular dynamics (aMD) and adaptive biasing force (ABF) simulations. "
2.	Dehydration (Water Stress) 12/11/2007 - "Targeted dehydration of the cytochrome P450cam (CYP101) distal pocket through mutagenesis of a distal pocket glycine to either valine or threonine results in the alteration of spin state equilibria, and has dramatic consequences on the catalytic rate, coupling efficiency, and kinetic solvent isotope effect parameters, highlighting an important role of the active-site hydration level on P450 catalysis. "

Related Drugs and Biologics

1.	Camphor 5-Monooxygenase (Camphor 5 Monooxygenase)
2.	Cytochromes
3.	Valine (L-Valine)
4.	Threonine (L-Threonine)
5.	Solvents
6.	Proteins (Proteins, Gene)
7.	Isotopes
8.	Glycine (Aminoacetic Acid)