Integrase Inhibitors

01/01/2020 - "Moreover, these data suggest that integrase inhibitors may be less effective in the treatment of HIV-1 infections in individuals who are also coinfected with HTLV-1."
01/01/2008 - "Integrase inhibitors: a new treatment option for patients with human immunodeficiency virus infection."
05/01/2006 - "It is only recently, however, that the efficacy of integrase inhibitors has been demonstrated in experimental animal model systems of retroviral infection, and in HIV-1 infected subjects. "
07/23/2004 - "These studies demonstrate integrase inhibitor activity in vivo and suggest that cellular immunity facilitates chemotherapeutic efficacy in retroviral infections."
11/18/2022 - "Integrase inhibitors (INIs) are an important class of drugs for treating HIV-2 infection, given the limited number of drugs active against this virus. "

11/01/2008 - "The first generation of integrase inhibitors recently approved or currently in late-stage clinical trials shows great promise for the treatment of human immunodeficiency virus (HIV) infection, but virus is expected to develop resistance to these drugs. "
07/01/2023 - "It seems the resistant mutation pattern attributed to integrase inhibitors was not diffent among studied patients; hence, the prescription of such inhibitors helps physicians to control HIV infection in Iranian HIV-infected patients."
03/01/2022 - "Among people with advanced HIV infection, those initiating B/F/TAF were less likely to discontinue/modify their regimen than those on any other regimen, and more likely to achieve viral suppression compared with those on bDRV but not compared with those on other integrase inhibitors."
11/01/2021 - "Earlier treatment strategies, and the introduction of integrase inhibitors in preferred first-line ART have fundamentally changed cardiovascular side effects due to HIV infection and ART. "
01/01/2021 - "Yet, the advantage of integrase inhibitors in treating TB/HIV coinfection is uncertain. "

01/01/2023 - "No integrase-inhibitor resistance was detected despite low-level viremia in a minority of participants."
01/01/2016 - "We describe here the case of a patient who experienced a relapse of KS and a rebound of HHV-8 viremia two months after switching from a PI to an integrase inhibitor-based cART. "
01/01/2015 - "This low-level viremia (termed "residual viremia") cannot be abolished in most patients, even after the addition of a new class of drug, i.e., viral integrase inhibitor, to the combined antiretroviral regimens. "
03/25/2008 - "In general, we find that the later in the life cycle an inhibitor acts, the more rapid the decay in viremia, and we illustrate this by comparing the effect of RT and integrase inhibitors on viral dynamics. "
10/05/2021 - "High Baseline Viremia: An Achilles Heel for Integrase Inhibitor-Based Antiretroviral Therapy?"

02/01/2021 - "Clinical trials have found that weight gain with integrase inhibitors is greatest for women and people of Black ethnicity. "
11/16/2023 - "While CD4 elevation is lower in EFV recipients than in integrase inhibitor (INSTI) recipients, weight gain is higher in INSTI recipients. "
11/15/2023 - "Hepatic steatosis after switching to integrase inhibitor-based regimens does not parallel short-term weight gain."
01/01/2023 - "Real-world experience with weight gain among pregnant women living with HIV who are using integrase inhibitors."
11/22/2022 - "Background: Integrase inhibitor (INSTI) use has been associated with greater weight gain (WG) among people living with HIV (PLWH), but it is unclear how this effect compares in magnitude to traditional risk factors for WG. "

12/01/2023 - "Integrase inhibitors help in the recovery of immune cells and improve the diversity of gut bacteria while reducing inflammation. "
01/01/2020 - "The impact of integrase inhibitor-based regimens on markers of inflammation among HIV naïve patients."
08/01/2015 - "Differential Reduction in Monocyte Activation and Vascular Inflammation With Integrase Inhibitor-Based Initial Antiretroviral Therapy Among HIV-Infected Individuals."
08/01/2022 - "Integrase Inhibitors Partially Restore Bacterial Translocation, Inflammation and Gut Permeability Induced by HIV Infection: Impact on Gut Microbiota."
01/01/2017 - "In ART switch studies, changing to an integrase inhibitor from a PI-, NNRTI-, or enfuvirtide-containing regimen has resulted in improvement in several markers of inflammation. "