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Cytochrome P-450 CYP11B2 (CYP11B2)

A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.
Also Known As:
CYP11B2; Aldosterone Synthase Cytochrome P-450; Aldosynthase; CYP 11B2; Cytochrome P-450c11AS; Cytochrome P450 11B2; Cytochrome P450Aldo; P450c11AS; 18-hydroxylase, Corticosterone; 18-monooxygenase, Corticosterone; Corticosterone 18 hydroxylase; Corticosterone 18 monooxygenase; Cytochrome P 450 CYP11B2; Cytochrome P 450c11AS; Steroid 18 Hydroxylase; Aldosterone Synthase; Corticosterone 18-hydroxylase; Corticosterone 18-monooxygenase; Steroid 18-Hydroxylase
Networked: 697 relevant articles (12 outcomes, 117 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Gomez-Sanchez, Celso E: 27 articles (01/2022 - 07/2002)
2. Rainey, William E: 27 articles (01/2022 - 08/2004)
3. Sasano, Hironobu: 26 articles (03/2022 - 08/2004)
4. Yamazaki, Yuto: 17 articles (01/2022 - 01/2016)
5. Hartmann, Rolf W: 17 articles (01/2019 - 06/2002)
6. Nakamura, Yasuhiro: 16 articles (01/2022 - 02/2011)
7. Nishimoto, Koshiro: 15 articles (01/2022 - 05/2010)
8. Satoh, Fumitoshi: 15 articles (01/2022 - 02/2011)
9. Mukai, Kuniaki: 14 articles (01/2022 - 05/2010)
10. Nanba, Kazutaka: 12 articles (01/2022 - 04/2013)

Related Diseases

1. Hypertension (High Blood Pressure)
2. Heart Failure
3. Fibrosis (Cirrhosis)
4. Diabetic Nephropathies (Diabetic Nephropathy)
5. Cardiovascular Diseases (Cardiovascular Disease)

Related Drugs and Biologics

1. Cytochrome P-450 CYP11B2 (CYP11B2)
2. Aldosterone
3. Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)
4. Proteins (Proteins, Gene)
5. Mineralocorticoid Receptor Antagonists
6. Transforming Growth Factor beta1 (TGF beta 1)
7. Collagen
8. Torsemide (Demadex)
9. Endothelin Receptor Antagonists
10. Aromatase Inhibitors

Related Therapies and Procedures

1. Therapeutics
2. Adrenalectomy
3. Subcutaneous Infusions
4. Renal Dialysis (Hemodialysis)
5. Denervation