Cytochrome P-450 CYP2E1 (CYP2E1)

An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.

Also Known As:

CYP2E1; CYP 2E1; CYP IIE1; CYPIIE1; Cytochrome P-450 (ALC); Cytochrome P-450 IIE1; Cytochrome P-450-J; Cytochrome P450 2E1; N-Nitrosodimethylamine Demethylase; 4 Nitrophenol 2 Hydroxylase; Cytochrome P 450 CYP2E1; Cytochrome P 450 IIE1; Cytochrome P 450 J; Dimethylnitrosamine N Demethylase; N Nitrosodimethylamine Demethylase; 4-Nitrophenol-2-Hydroxylase; Dimethylnitrosamine N-Demethylase

Networked: 1317 relevant articles (41 outcomes, 279 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cederbaum, Arthur I: 24 articles (01/2016 - 04/2002)
2.	Song, Byoung-Joon: 16 articles (01/2021 - 01/2009)
3.	Seitz, Helmut K: 12 articles (01/2022 - 01/2002)
4.	Abdelmegeed, Mohamed A: 12 articles (01/2019 - 01/2009)
5.	Wang, Xiaodong: 10 articles (01/2015 - 08/2005)
6.	Gonzalez, Frank J: 9 articles (05/2022 - 01/2005)
7.	Mueller, Sebastian: 9 articles (01/2022 - 02/2011)
8.	Wu, Defeng: 9 articles (01/2015 - 02/2008)
9.	Lee, Myung Gull: 9 articles (08/2008 - 06/2002)
10.	Fromenty, Bernard: 8 articles (01/2022 - 12/2005)

Related Diseases

1.	Inflammation (Inflammations) 01/05/2021 - "CYP2E1 suppression ameliorates I/R injury and protects BBB integrity by reducing both oxidative stress and inflammation." 12/01/2023 - "The interaction of these two pathways leads to the downregulation and recovery of CYP2E1, thus alleviating inflammation and nitration stress. " 06/01/2023 - "In conclusion, AFG1 ingestion induces TNF-α-mediated gastric inflammation, which upregulates CYP2E1 to promote AFG1-induced DNA damage in GECs." 06/01/2023 - "Treatment with the soluble TNF-α receptor sTNFR:Fc inhibited AFG1-induced gastric inflammation, and reversed CYP2E1 upregulation and DNA damage in mouse GECs. " 06/01/2023 - "AFG1-induced TNF-α-mediated inflammation enhances gastric epithelial cell injury via CYP2E1."
2.	Neoplasms (Cancer) 11/01/2023 - "The present study was conducted to determine; the prevalence of polymorphisms in GSTM1, GSTT1 and CYP2E1 genes, serum 8-hydroxy-2'-deoxygunosine levels, and the role of these markers in risk of cancer among agricultural workers occupationally exposed to pesticides. " 11/26/2019 - "We finally obtained a list of only five genes (AGXT; ALDOB; CYP2E1; IGFBP3; TOP2A) that were differentially expressed in tumor and nontumor tissues across studies and were significantly correlated to HCC prognosis. " 10/17/2017 - "However, the meta-analysis based on 5 eligible studies showed no significant association between CYP2E1 Dra I polymorphism and urinary cancer susceptibility in either dominant model or the allele model. " 10/17/2017 - "We found decreased urinary cancer risk among subjects carrying CYP2E1 RsaI/PstI c1c2 + c2c2 genotype and c2 allele (OR = 0.73, 95% CI = 0.68-0.79 and OR = 0.79, 95% CI = 0.74-0.85, respectively), with 3,301 cases and 3,786 controls from 14 studies. " 12/01/2014 - "The polymorphism of CYP2E1 Rsa I/Pst I gene and susceptibility to respiratory system cancer: a systematic review and meta-analysis of 34 studies."
3.	Non-alcoholic Fatty Liver Disease 01/01/2021 - "We have already shown that our newly developed CYP2E1 inhibitor 12-imidazolyl-1-dodecanol (I-ol) was therapeutically effective against alcoholic and nonalcoholic steatohepatitis. " 07/01/2017 - "In summary, this study demonstrates that TSG reduces oxidative stress by downregulating of CYP2E1 expression and JNK phosphorylation in NAFLD, and alleviates NAFLD ultimately. " 12/14/2016 - "This study suggests that Ly has a protective effect on NAFLD, down-regulates expression of TNF-α, and that CYP2E1 may be one of the action mechanisms for Ly." 03/01/2014 - "The aim of our study was to evaluate the effect of metabolic gene polymorphisms involved in the oxidative stress (GSTT1, GSTM1, SULT1A1, CYP2E1, and 1A1), lifestyle and nutrition aspects, and their interaction, on the risk of NAFLD. " 05/01/2008 - "The aim of the present study was to examine hepatic CYP2E1 activity in patients with NAFLD. "
4.	Insulin Resistance 01/01/2019 - "In conclusion, these data depict that insulin resistance through CYP2E1 may contribute to the pathogenesis of myopathic changes including myocardial contractile dysfunction, oxidative stress and mitochondrial injury, possibly through activation of iNOS and NLRP3 signaling." 01/01/2019 - "Inhibition of CYP2E1 attenuates myocardial dysfunction in a murine model of insulin resistance through NLRP3-mediated regulation of mitophagy." 12/20/2018 - "Author Correction: Effect of BI-1 on insulin resistance through regulation of CYP2E1." 01/01/2016 - "Effect of BI-1 on insulin resistance through regulation of CYP2E1." 01/01/2016 - "We propose that BI-1 protects against obesity-induced hepatic insulin resistance by regulating CYP2E1 activity and ROS production."
5.	Obesity 01/01/2022 - "In general, this study explains the relationship between CYP2E1 and energy metabolism, and provides a new perspective for the prevention and treatment of obesity." 08/01/2021 - "Although previous studies have reported the effect of CYP2E1 on obesity in animal models, the data remains controversial. " 01/01/2018 - "Our study is consistent with previous research and further claimes that CNVs containing CYP2E1 may be related to HTG and obesity. " 01/01/2012 - "In this report, we review our studies on whether induction of CYP2E1 can potentiate liver injury in obesity. " 05/01/2022 - "Translationally, a CYP2E1 inhibitor was found to activate the PPARα-FGF21-beige adipose axis and decrease obesity in wild-type mice, but not in liver-specific Ppara-null mice. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Cytochrome P-450 CYP2E1 (CYP2E1)
3.	Ethanol (Ethyl Alcohol)
4.	Cytochrome P-450 Enzyme System (Cytochrome P450)
5.	Antioxidants
6.	Cytochrome P-450 CYP1A1 (CYP1A1)
7.	Enzymes
8.	Cytochrome P-450 CYP1A2 (CYP1A2)
9.	Acetaminophen (Paracetamol)
10.	Methanol (Carbinol)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Therapeutics
3.	Resuscitation
4.	Oral Pathology
5.	Drug Therapy (Chemotherapy)