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Cytochrome P-450 CYP2D6 (CYP2D6)

A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.
Also Known As:
CYP2D6; Cytochrome P450 2D6; CYP 2D6; Debrisoquine 4-Monooxygenase; Imipramine 2-Hydroxylase; Sparteine Monooxygenase; 2-Hydroxylase, Imipramine; 4-Hydroxylase, Debrisoquine; 4-Monooxygenase, Debrisoquine; CYP2D6, Cytochrome P-450; Cytochrome P 450 CYP2D6; Debrisoquine 4 Hydroxylase; Debrisoquine 4 Monooxygenase; Hydroxylase, Debrisoquine; Imipramine 2 Hydroxylase; Monooxygenase, Sparteine; P-450 CYP2D6, Cytochrome; P450 2D6, Cytochrome; Debrisoquine 4-Hydroxylase; Debrisoquine Hydroxylase
Networked: 1532 relevant articles (76 outcomes, 397 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Schwab, Matthias: 21 articles (03/2022 - 11/2004)
2. Rae, James M: 18 articles (01/2017 - 12/2003)
3. Brauch, Hiltrud: 15 articles (03/2022 - 11/2007)
4. Gaedigk, Andrea: 15 articles (01/2022 - 03/2004)
5. Goetz, Matthew P: 15 articles (01/2018 - 12/2005)
6. Flockhart, David A: 15 articles (12/2014 - 12/2003)
7. Ingle, James N: 14 articles (01/2018 - 12/2005)
8. Schroth, Werner: 11 articles (03/2022 - 11/2007)
9. Sukasem, Chonlaphat: 11 articles (01/2022 - 01/2012)
10. Desta, Zeruesenay: 11 articles (01/2019 - 12/2003)

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Related Drugs and Biologics

1. Cytochrome P-450 CYP2D6 (CYP2D6)
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7. Cytochrome P-450 Enzyme System (Cytochrome P450)
8. Donepezil (Aricept)
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10. Apolipoproteins E (ApoE)

Related Therapies and Procedures

1. Therapeutics
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3. Drug Therapy (Chemotherapy)
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