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Cytochrome P-450 CYP1A2 (CYP1A2)

A cytochrome P-450 monooxygenase that can be induced by polycyclic aromatic xenobiotics in the liver of human and several animal species. This enzyme is of significant clinical interest due to the large number of drug interactions associated with its induction and its metabolism of THEOPHYLLINE. Caffeine is considered to be a model substrate for this enzyme. CYP1A2 activity can also be increased by environmental factors such as cigarette smoking, charbroiled meat, cruciferous vegetables, and a number of drugs including phenytoin, phenobarbital, and omeprazole.
Also Known As:
CYP1A2; CYP 1A2; Caffeine Demethylase; Cytochrome P-450 LM(4); Cytochrome P-450 LM4; Cytochrome P-450d; Cytochrome P450 1A2; CYP1A2, Cytochrome P-450; Cytochrome P 450 CYP1A2; Cytochrome P 450d; Demethylase, Caffeine; O-Dealkylase, Phenacetin; Phenacetin O Dealkylase; Phenacetin O-Dealkylase
Networked: 468 relevant articles (11 outcomes, 86 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Nebert, Daniel W: 12 articles (07/2013 - 04/2002)
2. Dalton, Timothy P: 8 articles (07/2006 - 04/2002)
3. Le Marchand, Loïc: 6 articles (03/2013 - 09/2002)
4. Moorthy, Bhagavatula: 5 articles (05/2015 - 08/2004)
5. Couroucli, Xanthi I: 5 articles (05/2015 - 08/2004)
6. Jiang, Weiwu: 5 articles (05/2015 - 08/2004)
7. Wilkens, Lynne R: 5 articles (03/2013 - 09/2002)
8. El-Sohemy, Ahmed: 5 articles (01/2013 - 03/2006)
9. Pavanello, Sofia: 5 articles (01/2013 - 09/2007)
10. Chan, Kenneth K: 5 articles (03/2012 - 03/2003)

Related Diseases

1. Liver Diseases (Liver Disease)
2. Asthma (Bronchial Asthma)
3. Neoplasms (Cancer)
4. Body Weight (Weight, Body)
5. Fibrosis (Cirrhosis)

Related Drugs and Biologics

1. Cytochrome P-450 Enzyme System (Cytochrome P450)
2. Caffeine (No Doz)
3. Theophylline (Theon)
4. Cytochrome P-450 CYP1A1 (CYP1A1)
5. Cytochrome P-450 CYP2E1 (CYP2E1)
6. Fluvoxamine (Luvox)
7. S-mephenytoin N-demethylase (CYP2B6)
8. Clozapine (Clozaril)
9. Tacrine (Cognex)
10. Proliferating Cell Nuclear Antigen (PCNA)

Related Therapies and Procedures

1. Castration
2. Aftercare (After-Treatment)
3. Oral Administration