Teriparatide (Parathar)

A polypeptide that consists of the 1-34 amino-acid fragment of human PARATHYROID HORMONE, the biologically active N-terminal region. The acetate form is given by intravenous infusion in the differential diagnosis of HYPOPARATHYROIDISM and PSEUDOHYPOPARATHYROIDISM. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

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Networked: 1461 relevant articles (186 outcomes, 345 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Marin, Fernando: 32 articles (01/2022 - 05/2006)
2.	Krege, John H: 30 articles (01/2019 - 03/2005)
3.	Miller, Paul D: 22 articles (12/2019 - 10/2002)
4.	Bilezikian, John P: 21 articles (12/2019 - 03/2004)
5.	Leder, Benjamin Z: 16 articles (01/2021 - 08/2009)
6.	Cosman, Felicia: 14 articles (11/2020 - 03/2004)
7.	Sugimoto, Toshitsugu: 14 articles (05/2020 - 09/2010)
8.	Fahrleitner-Pammer, Astrid: 14 articles (01/2019 - 02/2008)
9.	Chen, Peiqi: 14 articles (05/2012 - 06/2005)
10.	Miyakoshi, Naohisa: 13 articles (06/2022 - 01/2015)

Related Diseases

1.	Osteoporosis 01/01/2020 - "Once-weekly injection of 56.5-μg teriparatide formulation is a potent therapeutic agent for osteoporosis treatment. " 12/01/2017 - "Teriparatide is a potent therapeutic agent for the treatment of osteoporosis. " 09/01/2012 - "As the first FDA-approved anabolic agent for osteoporosis, teriparatide has proven effective for people at highest risk of fracture, despite limitations of expense, route of delivery, and length of treatment. " 12/01/2020 - "Further investigation on the safety and efficacy of teriparatide in higher doses for the long-term treatment of osteoporosis in postmenopausal women should be conducted through high-quality clinical trials." 01/01/2016 - "The results of this 24-month postmarketing surveillance study imply that teriparatide has a favorable safety profile and is effective in the treatment of patients with osteoporosis at high risk of fracture in Japan. "
2.	Postmenopausal Osteoporosis 08/22/2013 - "EFOS is the first longitudinal study in women with severe postmenopausal osteoporosis in the real world setting to show a substantial improvement in HRQoL during teriparatide treatment that was sustained during subsequent treatment with other medications. " 10/01/2019 - "Teriparatide is effective in the treatment of postmenopausal osteoporosis and is the only US Food and Drug Administration-approved anabolic agent that directly affects osteoblast function and contributes to bone remodeling. " 02/01/2012 - "All trials aimed to evaluate the efficacy of daily subcutaneous teriparatide injection in postmenopausal osteoporosis. " 02/01/2012 - "To determine the efficacy of teriparatide supplementation for improving bone mineral density (BMD) and fracture risk in postmenopausal osteoporosis and if effects vary with factors. " 01/01/2012 - "By increasing bone formation, teriparatide, an anabolic agent used in the treatment of postmenopausal osteoporosis, has shown promise in accelerating the rate of fracture healing. "
3.	Pain (Aches) 12/01/2020 - "20 μg/day teriparatide had a significant effect on pain severity to placebo or control (SMD 0.80, 95% CI, 1.16-0.43 SDs lower) and also decreased the incidence of vertebral fractures compared to placebo (relative risk 0.31, 95% CI 0.21 to 0.46). " 12/01/2020 - "The efficacy of low and high dose teriparatide on lumbar spine bone mineral density, vertebral fracture incidence and pain is unknown. " 09/01/2018 - "With regard to the early phase (within the first 7 days of treatment), teriparatide significantly improved pain-like behavior in the von Frey test, the paw flick test and the spontaneous pain test. " 09/01/2018 - "Pain-like behavior in the von Frey test was significantly improved by teriparatide treatment in OVX mice. " 01/01/2014 - "Teriparatide treatment also resulted in a significant reduction in self-reported pain intensity and a significant improvement in physical health as measured by VAS and ODI scores, respectively. "
4.	Osteonecrosis (Kienbock's Disease) 01/01/2016 - "Teriparatide had positive effects in preventing osteonecrosis; therefore, teriparatide could be an effective agent for MRONJ." 03/01/2020 - "Teriparatide (TPTD) treatment for Stage II-III medication-related osteonecrosis of the jaw (MRONJ) in osteoporotic patients has yielded promising results in uncontrolled studies. " 11/01/2016 - "Efficacy of Short-term Teriparatide for Hip Osteonecrosis." 10/01/2020 - "Teriparatide Promotes Bone Healing in Medication-Related Osteonecrosis of the Jaw: A Placebo-Controlled, Randomized Trial." 01/01/2016 - "Histopathological Effects of Teriparatide in Medication-Related Osteonecrosis of the Jaw: An Animal Study."
5.	Back Pain (Backache) 01/01/2016 - "EQ-5D scores and back pain VAS scores were significantly improved from baseline at each post-baseline observation during teriparatide treatment. " 01/01/2006 - "Teriparatide-treated patients had a reduced incidence of back pain versus those receiving a comparator during an observation encompassing clinical trials plus 30 months of posttreatment observation." 05/01/2013 - "A primary objective of this retrospective study was to define the efficacy of teriparatide in terms of bone mineral density (BMD) changes and relief of back pain in clinical practice. " 09/01/2012 - "The aims of this study were to evaluate the effectiveness of teriparatide treatment on back pain-related functional limitations and to investigate on patients HRQoL. " 02/01/2006 - "The rates of back pain, moderate or severe back pain, and severe back pain per 100 patient-years were numerically lower in the teriparatide versus comparator groups in each study. "

Related Drugs and Biologics

1.	Diphosphonates (Bisphosphonates)
2.	Alendronate (Alendronate Sodium)
3.	Denosumab
4.	Glucocorticoids
5.	Parathyroid Hormone (Parathormone)
6.	Risedronic Acid (Actonel)
7.	Teriparatide (Parathar)
8.	abaloparatide
9.	Zoledronic Acid (Zometa)
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Subcutaneous Injections
4.	Pedicle Screws
5.	Parathyroidectomy