|1.||Yang, Peiying: 2 articles (10/2012 - 10/2007)|
|2.||Newman, Robert A: 2 articles (10/2012 - 10/2007)|
|3.||Kudva, Shobha: 1 article (10/2015)|
|4.||Pilkington, Suzanne M: 1 article (10/2015)|
|5.||Rhodes, Lesley E: 1 article (10/2015)|
|6.||Nicolaou, Anna: 1 article (10/2015)|
|7.||Murphy, Sharon A: 1 article (10/2015)|
|8.||Mano, Nariyasu: 1 article (07/2015)|
|9.||Furugen, Ayako: 1 article (07/2015)|
|10.||Yamaguchi, Hiroaki: 1 article (07/2015)|
|1.||Diabetic Nephropathies (Diabetic Nephropathy)
01/01/2005 - "We showed that a 12-LO inhibitor, cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate (CDC) inhibited 12/15-LO activity in vivo and assessed the efficacy of another 12/15-LO inhibitor, N-benzyl-N-hydroxy-5-phenylpentamidine (BHPP), to diminish urinary 12-HETE and ameliorate diabetic nephropathy (DN) over 4 months. "
|2.||Brain Injuries (Brain Injury)
11/01/2011 - "This study also suggests the potential use of DHA, AA, 5- and 12-HETE as biochemical markers of brain injury and to monitor the impact of interventions."
01/01/1989 - "The purpose of this study was to determine whether experimental fluid percussion brain injury in cats is associated with increased systemic levels of prostaglandins and the lipoxygenase product, 12-HETE. "
01/01/1989 - "Increased plasma PGE2, 6-keto-PGF1 alpha, and 12-HETE levels following experimental concussive brain injury."
07/01/2000 - "Culture in hypoxia further increased intracellular 12-HETE threefold but had no additional effect on 12-HETrE. "
07/01/2000 - "Hypoxia did not significantly increase extracellular 12-HETE or 12-HETrE; however, it caused more than 90% inhibition of PGE2 synthesis. "
06/01/1993 - "Production of HETE was greatly increased at five hours of reoxygenation after 45 minutes of hypoxia [5-HETE = 12.0(SEM 0.5), 12-HETE = 23.6(1.1) ng.mg-1 protein]. "
06/01/1986 - "Under hypoxia, verapamil decreased significantly 12-HETE and X production by fibroblasts (P less than 0.01 and P less than 0.05), whereas the synthesis in myocytes was not changed. "
04/01/1998 - "In additional studies, we found that 12-HETE enhanced hypoxia-induced sickle-red-cell-endothelial adherence, and that this effect was mediated by potentiation of agonist-induced upregulation of the expression of the mRNA for vascular cell adhesion molecule-1 (VCAM-1) in endothelial cells. "
11/01/2000 - "These results suggested the possible involvement of 12-HETE with the intimal hyperplasia under PR conditions."
11/01/2000 - "In the in vivo study in the PR group, the intimal hyperplasia and the plasma 12-HETE levels in the OPC-29030 group were significantly inhibited, compared with those of the control group. "
11/01/2000 - "The mechanism of reducing the intimal hyperplasia may be that OPC-29030 inhibited 12-HETE production, which did not inhibit proliferation while inhibiting migration of the smooth muscle cell. "
02/01/1987 - "In epidermis, LTB4 and 12-HETE caused some spongiosis as well as hyperplasia and increased tritiated thymidine autoradiographic labeling index. "
01/01/2007 - "In addition, treatment of HaCaT cells with the 12-lipoxygenase metabolite 12 (S)-hydroxyeicosatetraenoic acid (12(S)-HETE) directly stimulated DNA synthesis and mitogenesis, and injection of insulin-like growth factor-II into the skin of hairless mice induced epidermal hyperplasia. "
08/25/1986 - "12-HETE synthesis is markedly increased in glomeruli from rats with nephrotoxic serum nephritis and leukotriene B4 synthesis in glomeruli from rats with cationic bovine gamma-globulin-induced glomerulonephritis. "
11/01/1999 - "In this study we assessed the effect of a TxA2 synthase inhibitor, Dazmegrel, and a TxA2 receptor antagonist, SQ-29 548, on glomerular PGE2, LTB4, and 12-HETE synthesis in a model of mesangial nephritis induced in the rat by the administration of a monoclonal antibody against the Thy 1.1 antigen of rat mesangial cells. "
|1.||4- (3- (biotinylaminohexamethylenaminocarbonyl)propanoylaminomethyl)- 2- methyl- 1,3- dithiolane- 2- yl- (Ala(7))phalloidin
|5.||Messenger RNA (mRNA)
|8.||Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
|9.||Thy-1 Antigens (Antigens, Thy 1)
|10.||Biological Markers (Surrogate Marker)