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12-Hydroxy-5,8,10,14-eicosatetraenoic Acid

A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)
Also Known As:
12 S Hydroxyeicosatetraenoic Acid; Acid, 12-S-Hydroxyeicosatetraenoic; 12-HETE; 12-R-HETE; 12-S-HETE; 12-S-Hydroxyeicosatetraenoic Acid
Networked: 145 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Yang, Peiying: 4 articles (01/2022 - 10/2007)
2. Shureiqi, Imad: 2 articles (01/2022 - 10/2012)
3. Gross, Eric R: 2 articles (11/2021 - 04/2003)
4. Cheng, Xu: 2 articles (10/2021 - 01/2018)
5. Huang, Zan: 2 articles (10/2021 - 01/2018)
6. Ji, Yan-Xiao: 2 articles (10/2021 - 01/2018)
7. Li, Hongliang: 2 articles (10/2021 - 01/2018)
8. Liao, Rufang: 2 articles (10/2021 - 01/2018)
9. Ma, Xin-Liang: 2 articles (10/2021 - 01/2018)
10. She, Zhi-Gang: 2 articles (10/2021 - 01/2018)

Related Diseases

1. Inflammation (Inflammations)
2. Diabetic Nephropathies (Diabetic Nephropathy)
3. Brain Injuries (Brain Injury)
4. Hypoxia (Hypoxemia)
5. Hyperplasia

Related Drugs and Biologics

1. 4- (3- (biotinylaminohexamethylenaminocarbonyl)propanoylaminomethyl)- 2- methyl- 1,3- dithiolane- 2- yl- (Ala(7))phalloidin
2. Leukotriene B4
3. Arachidonate 12-Lipoxygenase (12 Lipoxygenase)
4. Enzymes
5. 15-hydroxy-5,8,11,13-eicosatetraenoic acid
6. Dinoprostone (PGE2)
7. Lipoxygenase (Lipoxygenase-1)
8. Hydroxyeicosatetraenoic Acids (HETE)
9. Acids
10. Messenger RNA (mRNA)

Related Therapies and Procedures

1. Ligation
2. Contact Lenses