Cytochrome P-450 CYP1A1 (CYP1A1)

A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.

Also Known As:

Networked: 2170 relevant articles (28 outcomes, 504 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Moorthy, Bhagavatula: 24 articles (04/2022 - 03/2002)
2.	El-Kadi, Ayman O S: 23 articles (09/2021 - 09/2004)
3.	Jiang, Weiwu: 21 articles (04/2022 - 01/2003)
4.	Wang, Lihua: 19 articles (04/2022 - 07/2007)
5.	Nebert, Daniel W: 19 articles (03/2018 - 11/2002)
6.	Couroucli, Xanthi I: 15 articles (04/2022 - 03/2002)
7.	Korashy, Hesham M: 14 articles (12/2021 - 09/2004)
8.	Safe, Stephen: 14 articles (01/2021 - 01/2004)
9.	Androutsopoulos, Vasilis P: 11 articles (08/2018 - 06/2009)
10.	Uno, Shigeyuki: 11 articles (03/2018 - 11/2002)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2021 - "This study observed an increased expression of MAPKs, Keap1, ARNT, AhR, and CYP1A1, whereas decreased expression of HO-1 and Nrf2 in DMBA-induced cancer-bearing experimental animals. " 02/26/2019 - "Methods: In the present study, 250 patients with oral pre-cancer and/or cancer and 250 healthy controls were genotyped for CYP1A1 T6235C, C4887A and A4889G polymorphisms by the PCR-RFLP method. " 02/26/2019 - "Background: The aim of this study was to evaluate any association between CYP1A1 (T6235C and C4887A, A4889G) gene polymorphisms and the risk of oral pre-cancer and cancer. " 01/01/2016 - "Many studies have investigated the association between the CYP1A1 MspI and Ile462Val polymorphisms and digestive tract cancer (DTC) risk in different groups of populations, but their results were inconsistent. " 01/01/2014 - "In this study, a meta-analysis of this literature aimed to clarify associations of CYP1A1 genetic polymorphisms with digestive tract cancer susceptibility in Chinese populations. "
2.	Carcinogenesis 04/01/2016 - "Based on systematic review, we designed a study to screen CYP1A1 and GSTP1 genes for mutation and their possible association with breast carcinogenesis. " 05/01/2003 - "Our study therefore suggests that the CYP1A1 Ile(462)Val variant allele might play a role in lung carcinogenesis among non-smokers, possibly in combination with the GSTM1 null genotype." 02/01/2023 - "The homozygous A/A genotype of the AhR gene (rs2066853) and the heterozygous T/C genotype of the CYP1A1 SNP (CYP1A1-MspI) appeared to be associated with an increased risk of cervical tumorigenesis (ORa = 2.81; ORa = 5.52, respectively). " 01/01/2021 - "Over the last four decades, a variety of natural products and synthetic compounds which interact with CYP1A1/1B1 have been identified as effective chemo-preventive agents against chemical carcinogenesis. " 12/15/2017 - "It has been well reported that CYP1A1 specific inhibitors prevents carcinogenesis. "
3.	Breast Neoplasms (Breast Cancer) 12/01/2022 - "This study aims to assess breast cancer (BC) association with metals and whether polymorphisms in CYP1A1, CYP1B1, GSTM1 and GSTT1 act as confounders or as modifiers of those relationships. " 01/01/2021 - "Evaluation of association studies and a systematic review and meta-analysis of CYP1A1 T3801C and A2455G polymorphisms in breast cancer risk." 01/01/2019 - "The aim of the study was to evaluate the association of CYP1A1 M2 (A2455G) includes rs1048943 of this SNP polymorphism with the risk of breast cancer in Mazandaran province. " 10/01/2017 - "In the present study, the effect of E2/ER on the expression of AhR and CYP1A1 genes was investigated for MCF-7 clonal variant (MCF-7 CV) breast cancer cells expressing ER. " 01/01/2016 - "Based on the study results, CYP1A1 M2 and M4 polymorphisms do not seem to play a major role in breast cancer risk among Jordanian females."
4.	Lung Injury 11/01/2020 - "Altogether, these data provide novel insights into the involvement of CYP1A1 in LPS-induced lung injury." 09/01/2014 - "Our results support the hypothesis that CYP1A1 protects against hyperoxic lung injury by decreasing oxidative stress. " 09/01/2014 - "The mechanistic role(s) of CYP1A1 in hyperoxic lung injury in vivo is not known. " 09/01/2006 - "We investigated the hypothesis that apoptosis plays a critical role in lung injury and down-regulation of CYP1A1 induction in mixed exposures to CD and PAHs. " 03/01/2006 - "In conclusion, because previous studies have shown beneficial effects of CYP1A1 induction in hyperoxic lung injury, our current observations showing maintenance of pulmonary CYP1A1 induction by iNO (20 ppm) + hyperoxia through the 168-h period support the hypothesis that this phenomenon may contribute to the protective effects of iNO against hyperoxic injury."
5.	Hyperoxia 06/01/2006 - "The improved alveolarization in animals given RA + hyperoxia, in conjunction with the attenuation of CYP1A1 and 1A2 expression in these animals, suggests that this phenomenon may play a role in the beneficial effects of RA." 01/01/2018 - "Hyperoxia exposure of CYP1A1-Luc mice for 7 and 14 days resulted in 4- and 30-fold increases, respectively, in hepatic Luc (CYP1A1) expression, compared to room air controls. " 09/01/2014 - "On the other hand, Cyp1a1(-/-) mice showed higher levels after 48-72 h of hyperoxia exposure compared to WT mice. " 09/01/2014 - "Eight- to ten-week-old male WT (C57BL/6J) or Cyp1a1(-/-) mice were exposed to hyperoxia (>95% O2) or room air for 24-72 h. " 12/01/2008 - "Our results strongly suggest that hyperoxia transcriptionally activates CYP1A1 expression in human lung cell lines by AHR-dependent mechanisms, and that CYP1A1 induction is associated with decreased toxicity. "

Related Drugs and Biologics

1.	Cytochrome P-450 Enzyme System (Cytochrome P450)
2.	Cytochrome P-450 CYP1A1 (CYP1A1)
3.	Messenger RNA (mRNA)
4.	Proteins (Proteins, Gene)
5.	Cytochrome P-450 CYP2E1 (CYP2E1)
6.	Carcinogens
7.	Enzymes
8.	Cytochrome P-450 CYP1A2 (CYP1A2)
9.	Polychlorinated Dibenzodioxins (TCDD)
10.	Estrogens (Estrogen)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Therapeutics
3.	Chemoprevention
4.	Drug Therapy (Chemotherapy)
5.	Hormone Replacement Therapy (Therapy, Hormone Replacement)