Cytochrome P-450 CYP2B1 (PROD)

A major cytochrome P-450 enzyme which is inducible by PHENOBARBITAL in both the LIVER and SMALL INTESTINE. It is active in the metabolism of compounds like pentoxyresorufin, TESTOSTERONE, and ANDROSTENEDIONE. This enzyme, encoded by CYP2B1 gene, also mediates the activation of CYCLOPHOSPHAMIDE and IFOSFAMIDE to MUTAGENS.

Also Known As:

PROD; BROD; 7-Benzyloxyresorufin O-Dealkylase; 7-Pentylresorufin O-Depentylase; CYP 2B1; Cytochrome P450 2B1; 7 Benzyloxyresorufin O Dealkylase; 7 Pentylresorufin O Depentylase; Benzyloxyresorufin O Dealkylase; Cytochrome P 450 CYP2B1; O-Dealkylase, Pentoxyresorufin; Pentoxyresorufin O Dealkylase; Benzyloxyresorufin O-Dealkylase; CYP2B1; Pentoxyresorufin O-Dealkylase

Networked: 286 relevant articles (10 outcomes, 49 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Granö, Niklas: 10 articles (04/2016 - 05/2009)
2.	Karjalainen, Marjaana: 10 articles (04/2016 - 05/2009)
3.	Roine, Mikko: 10 articles (04/2016 - 05/2009)
4.	Anto, Jukka: 8 articles (10/2015 - 05/2009)
5.	Edlund, Virve: 8 articles (10/2015 - 05/2009)
6.	Itkonen, Arja: 8 articles (10/2015 - 05/2009)
7.	Saari, Erkki: 6 articles (10/2015 - 08/2013)
8.	Cvitković, Ante: 6 articles (09/2014 - 04/2007)
9.	Heinimaa, Markus: 5 articles (04/2016 - 05/2009)
10.	Salmons, Brian: 4 articles (01/2009 - 05/2002)

Related Diseases

1.	Fibrosis (Cirrhosis) 01/01/2018 - "The study aims to analyze the general feature and predictive factors of on-treatment hepatic decompensation in hepatitis C virus (HCV) genotype 1b-infected patients with advanced fibrosis and compensated cirrhosis who receive treatment with PrOD. " 01/01/2018 - "A real-word cohort enrolled 189 HCV genotype 1b patients with advanced fibrosis and compensated cirrhosis treated with 12-week PrOD. " 01/01/2017 - "Proportion of persons with eGFR decrease >30 ml/min/1.73 m2 was higher among the PrOD group, but presence of cirrhosis did not appear to affect this. " 03/01/2019 - "Our real-world data in Taiwan revealed that PrOD-based rescue therapy is well-tolerated and highly effective for genotype 1 CHC patients with advanced fibrosis failing previous therapy with PEG-IFN plus RBV." 01/01/2022 - "This study focuses on the pharmacokinetic dynamics of PrOD with CsA in Asian organ transplant recipients with severe liver fibrosis or cirrhosis who undergo concurrent treatment with PrOD treatment and CsA. "
2.	Neoplasms (Cancer) 12/01/2001 - "In conclusion, a successful therapy with CPA, helped by forced expression of CYP2B1 in tumor cells (as recently proposed) will, in addition, be profoundly modified by its phosphorylation status." 10/15/2019 - "Our findings suggest that Brod-Posavina County had the highest cancer risk for UUCs, especially among females, when compared to Croatia as a whole during 2001-2011. " 01/01/2019 - "We provide a freely available, user-friendly, browseable interactive web-based application for exploring the results of our transcriptome-wide analyses across 17 different cancers in TCGA at http://ls-shiny-prod.uwm.edu/edge_in_tcga. " 09/01/2014 - "In the first cycle, the response rate in Brod-Posavina County was 53.2%, with 71 cancers detected at a mean age of 61.3 years. " 03/01/2002 - "Moreover, they suggest that in order to achieve a potentiation on cell killing when the two suicide systems HSVtk/GCV and CYP2B1/CPA are combined, co-expression of both genes in the same tumor cell would be necessary."
3.	Proteinuria 09/01/2002 - "CYP2B1 inhibitors also provided significant protection against PAN induced proteinuria. " 09/01/1983 - "Subjects living in the endemic area of Posavina round Slavonski Brod have a significantly greater incidence of proteinuria (13.6%) than those living under the same conditions in the area where endemic nephropathy has not been observed (5.5%). "
4.	Infections 01/01/2021 - "The aim of this study was to find out by means of antibody testing how many high school students in Havlíčkův Brod have undergone the infection. " 08/01/2019 - "The aim of the present study was to investigate the efficacy and safety of PrOD in RT patients with hepatitis C virus (HCV) infection in a single center real-life experience. " 08/01/2019 - "PrOD regime can be successfully and safely used in RT recipients with HCV infection with close follow-up." 01/01/2015 - "Although indicated for the treatment of HCV genotype 1 infection, PrOD is also recommended for the treatment of HCV in patients coinfected with HIV. " 01/01/2015 - "This review aims to discuss the pharmacology, efficacy, safety, drug interactions, and viral drug resistance of PrOD in the treatment of HCV genotype 1 infections. "
5.	Prodromal Symptoms 01/01/2003 - "The aim of this study was to describe the PROD-screen, an instrument for screening prodromal symptoms indicating risk for psychotic conversion in the near future. " 01/01/2003 - "The concordant validity of PROD-screen for prodromal symptoms of psychosis was assessed in a large epidemiologically mixed sample of research subjects (n = 132) by comparing PROD-screen scores with the prodromal diagnosis made by Structured Interview for Prodromal Symptoms as a gold standard. " 02/01/2010 - "Vulnerability to psychosis was defined in three ways: having a parent with a history of psychosis, having prodromal symptoms of psychosis measured by PROD-screen questionnaire at the age of 15-16 years or having actually developed psychosis after the field study (in 2002-2005). " 01/01/2020 - "In the general population-based Northern Finland Birth Cohort 1986 (n = 8 229), we studied the relationship between teacher-assessed learning deficits, special talents and general school success at age 8 years and both prodromal symptoms (PROD-screen) at age 15-16 years and the occurrence of psychoses by age 30 years. " 01/01/2011 - "In the 15-16-year follow-up survey, the adolescents completed the Youth Self-Report questionnaire as well as the PROD-Screen questionnaire that addressed prodromal symptoms of psychosis. "

Related Drugs and Biologics

1.	Ribavirin (Virazole)
2.	paritaprevir
3.	Ritonavir (Norvir)
4.	dasabuvir
5.	ombitasvir
6.	Therapeutic Uses
7.	Cytochrome P-450 CYP1A1 (CYP1A1)
8.	Cytochrome P-450 CYP2B1 (PROD)
9.	Enzymes
10.	Cyclophosphamide (Cytoxan)

Related Therapies and Procedures

1.	Therapeutics
2.	Liver Transplantation
3.	Cell- and Tissue-Based Therapy (Cell Therapy)
4.	Acupuncture Therapy
5.	Percutaneous Collagen Induction