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Buthionine Sulfoximine

A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
Also Known As:
Sulfoximine, Buthionine; Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-
Networked: 400 relevant articles (14 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Spitz, Douglas R: 5 articles (12/2021 - 10/2011)
2. Fath, Melissa A: 4 articles (12/2021 - 10/2011)
3. Lokhandwala, Mustafa F: 4 articles (02/2021 - 09/2008)
4. Lewis-Wambi, Joan S: 4 articles (01/2018 - 01/2008)
5. Park, Woo Hyun: 4 articles (01/2016 - 08/2008)
6. Reynolds, C P: 4 articles (07/2014 - 12/2000)
7. Romero-Canelón, Isolda: 3 articles (03/2022 - 11/2013)
8. Sadler, Peter J: 3 articles (03/2022 - 11/2013)
9. Banday, Anees Ahmad: 3 articles (02/2021 - 09/2008)
10. Anderson, Clarke P: 3 articles (01/2016 - 04/2003)

Related Diseases

1. Neoplasms (Cancer)
2. Neuroblastoma
3. Cataract (Cataracts)
4. Carcinoma (Carcinomatosis)
5. Wounds and Injuries (Trauma)

Related Drugs and Biologics

1. Glutathione (Reduced Glutathione)
2. Antioxidants
3. Nifurtimox
4. Reactive Oxygen Species (Oxygen Radicals)
5. Cisplatin (Platino)
6. Arsenic Trioxide (Trisenox)
7. Thioctic Acid (Lipoic Acid)
8. Acetaminophen (Paracetamol)
9. 1-phenyl-3,3-dimethyltriazene (PDT)
10. Doxorubicin (Adriamycin)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Photochemotherapy (Photodynamic Therapy)
4. Aftercare (After-Treatment)
5. Microspheres (Microsphere)