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Buthionine Sulfoximine

A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
Also Known As:
Sulfoximine, Buthionine; Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-
Networked: 317 relevant articles (11 outcomes, 21 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Reynolds, C P: 4 articles (01/2014 - 12/2000)
2. Reynolds, C Patrick: 3 articles (10/2015 - 04/2003)
3. Savarino, Andrea: 3 articles (10/2015 - 01/2009)
4. Rodríguez-Gómez, Isabel: 3 articles (08/2014 - 08/2010)
5. Wangensteen, Rosemary: 3 articles (08/2014 - 08/2010)
6. Vargas, Félix: 3 articles (08/2014 - 08/2010)
7. Lokhandwala, Mustafa F: 3 articles (08/2011 - 09/2008)
8. Park, Woo Hyun: 3 articles (08/2010 - 08/2008)
9. Jordan, V Craig: 3 articles (03/2009 - 01/2008)
10. Lewis-Wambi, Joan S: 3 articles (03/2009 - 01/2008)

Related Diseases

1. Neoplasms (Cancer)
2. Neuroblastoma
3. Cataract (Cataracts)
4. Carcinoma (Carcinomatosis)
5. Wounds and Injuries (Trauma)

Related Drugs and Biologics

1. Glutathione (Reduced Glutathione)
2. Antioxidants
3. Thioctic Acid (Lipoic Acid)
4. Acetaminophen (Paracetamol)
5. Cisplatin (Platino)
6. Doxorubicin (Adriamycin)
7. diethyl maleate
8. arsenic trioxide (Trisenox)
9. Reactive Oxygen Species (Oxygen Radicals)
10. Catalase

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Drug Therapy (Chemotherapy)
3. Aftercare (After-Treatment)
4. Microspheres (Microsphere)
5. Injections