Okadaic Acid

A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. It is produced by DINOFLAGELLATES and causes diarrhetic SHELLFISH POISONING.

Also Known As:

Networked: 649 relevant articles (9 outcomes, 52 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Méndez, Josefina: 13 articles (01/2015 - 07/2010)
2.	Valdiglesias, Vanessa: 9 articles (01/2016 - 07/2010)
3.	Botana, Luis M: 8 articles (01/2021 - 01/2009)
4.	Laffon, Blanca: 8 articles (01/2016 - 07/2010)
5.	López, Manuela G: 7 articles (01/2022 - 12/2005)
6.	Nath, Chandishwar: 7 articles (10/2016 - 01/2010)
7.	Botana, L M: 7 articles (12/2011 - 04/2000)
8.	Vieytes, M R: 7 articles (12/2011 - 04/2000)
9.	Louzao, M Carmen: 6 articles (01/2021 - 01/2009)
10.	Vilariño, Natalia: 6 articles (01/2021 - 01/2009)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 03/01/2019 - "Okadaic acid (OA)‑induced neurotoxicity may be considered a novel tool used to study Alzheimer's disease (AD) pathology, and may be helpful in the development of a novel therapeutic approach. " 09/01/2018 - "Utilizing zebrafish and okadaic acid to study Alzheimer's disease." 03/01/2015 - "Okadaic acid: a tool to study regulatory mechanisms for neurodegeneration and regeneration in Alzheimer's disease." 07/01/2013 - "Okadaic acid induced neurotoxicity: an emerging tool to study Alzheimer's disease pathology." 02/29/2000 - "Previous studies have shown that okadaic acid (OA) evokes tau phosphorylation and neurofibrillary changes in vivo, and in cultured neurons, that resemble Alzheimer's disease pathogenesis. "
2.	Neuroblastoma 01/09/2009 - "In this study, we investigated the protective effects of okadaic acid on MPP(+)-induced cell death in SH-SY5Y neuroblastoma cells. " 12/15/2017 - "In the current study, we intend to evaluate the effects of SLM against okadaic acid (OA)-induced tau hyperphosphorylation and microtubules instability in human neuroblastoma (SH-SY5Y) cells. " 06/01/2017 - "In this study, we investigated the potential therapeutical effects of human dental pulp stem cells (hDPSCs) on AD cellular model which established by okadaic acid (OA)-induced damage to human neuroblastoma cell line, SH-SY5Y, in vitro for 24 h. " 09/01/2003 - "The current study defines the relationship between FAK dephosphorylation and degradation in neuroblastoma cells using okadaic acid (OA). " 01/01/2022 - "Okadaic acid was applied to SH-SY5Y (human neuroblastoma cell line) cells to create an AD model. "
3.	Neoplasms (Cancer) 10/01/2023 - "Okadaic acid has been regarded as a tumor-promoting compound and an environmental co-factor in the incidence of fibropapillomatosis, a frequent disease in juvenile green turtles inhabiting this geographic region. " 02/01/2016 - "Okadaic acid treatment inhibited SAHA-mediated apoptosis in both the HSC-3 and HSC-4 cell lines, wheras SAHA induced a profound in vivo inhibition of tumor growth in HSC-3 xenografts. " 06/01/2013 - "The marine toxin okadaic acid induces alterations in the expression level of cancer-related genes in human neuronal cells." 06/01/2007 - "Cfl1 was specifically overexpressed in SCL-LMO1 tumors; inactivation of Cfl1 using okadaic acid resulted in suppression of leukemic cell growth. " 12/01/2002 - "The dominant negative c-jun TAM-67 has been shown to inhibit tumor promotion induced by 12-O-tetradecanoylphorbol-13-acetate and okadaic acid (OA). "
4.	Shellfish Poisoning 12/07/2022 - "In this study, a lateral flow immunoassay (LFIA) was developed to detect okadaic acid (OA) belonging to the diarrheic shellfish poisoning group of aquatic toxins. " 02/01/2013 - "Study of cytoskeletal changes induced by okadaic acid in HL-7702 liver cells and development of a fluorimetric microplate assay for detecting diarrhetic shellfish poisoning." 04/01/2023 - "Okadaic acid and DTXs cause diarrheic shellfish poisoning (DSP) in human consumers, and also cause cytotoxic, immunotoxic and genotoxic effects in a variety of mollusks and fishes at different life stages in vitro. " 01/25/2023 - "Okadaic acid (OA) is a marine biotoxin that accumulates in seafood and can cause diarrheic shellfish poisoning if consumed. " 01/01/2023 - "Okadaic acid (OA) and its analogues cause diarrhetic shellfish poisoning (DSP) in humans, and risk assessments of these toxins require toxicity equivalency factors (TEFs), which represent the relative toxicities of analogues. "
5.	Wounds and Injuries (Trauma) 07/01/2008 - "The effects of 48 h okadaic acid (OA) treatment and the ability to recover the induced toxicological injuries were examined in Enchytraeus crypticus of different ages (25 days and 3 months). " 06/20/2003 - "Pretreating human keratinocytes with the PP2A inhibitor, okadaic acid, prevented the beta2-AR-induced inhibition of migration, either as isolated cells or as a confluent sheet of cells repairing an in vitro "wound" and also prevented the beta2-AR-induced reduction in ERK phosphorylation. " 07/01/2000 - "These injuries distinctly differed from those caused by the representative diarrhetic shellfish toxin, okadaic acid." 05/01/2010 - "[Protective effects of IGF-1 on cell injuries and tau hyperphosphorylation induced by okadaic acid]." 05/01/2010 - "To investigate the effects of insulin-like growth factor-1 (IGF-1) on cell injuries and tau hyperphosphorylation induced by okadaic acid (OA). "

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Related Therapies and Procedures

1.	Spinal Injections
2.	Aftercare (After-Treatment)
3.	Intraperitoneal Injections
4.	Therapeutics
5.	Hepatectomy