|1.||Parvin, Jeffrey D: 4 articles (03/2013 - 06/2004)|
|2.||Swisher, Elizabeth M: 3 articles (03/2013 - 04/2008)|
|3.||Taniguchi, Toshiyasu: 3 articles (03/2013 - 04/2008)|
|4.||Chambon, Monique: 3 articles (01/2013 - 05/2003)|
|5.||Rosen, Eliot M: 3 articles (01/2013 - 01/2003)|
|6.||Monteiro, Alvaro N A: 3 articles (06/2010 - 06/2004)|
|7.||Goldberg, I D: 3 articles (08/2001 - 01/2001)|
|8.||Rosen, E M: 3 articles (08/2001 - 01/2001)|
|9.||Privat, Maud: 2 articles (11/2014 - 06/2010)|
|10.||Troudi, Wafa: 2 articles (11/2014 - 07/2007)|
|1.||Ovarian Neoplasms (Ovarian Cancer)
05/05/2010 - "Targets within this pathway could provide strategies for modulation of BRCA1 protein, which may prove therapeutically beneficial for breast and ovarian cancer treatment."
02/01/2004 - "To clarify the possible involvement of BRCA1 in the development of sporadic ovarian neoplasms, this study analysed the immunohistochemical expression of BRCA1 protein in normal ovarian surface epithelium and 119 epithelial ovarian tumours (19 benign, 24 borderline, and 76 malignant tumours). "
11/01/2011 - "Epithelial ovarian cancers with negative BRCA1 protein expression were identified in younger patients, showed a significantly better overall survival, prolonged treatment intervals and a tendency for an extended progression free time interval. "
11/01/2011 - "Loss of BRCA1 protein expression as indicator of the BRCAness phenotype is associated with favorable overall survival after complete resection of sporadic ovarian cancer."
06/15/2010 - "Here, we use biochemical and cell-based transcriptional assays to assess the structural and functional defects associated with a large set of 117 distinct BRCA1 missense variants within the essential BRCT domain of the BRCA1 protein that have been documented in individuals with a family history of breast or ovarian cancer. "
|2.||Breast Neoplasms (Breast Cancer)
09/01/2012 - "This study aims to assess BRCA1 protein expression and the role of BRCA1 promoter methylation in sporadic breast cancer in North Indian population and to correlate these with known prognostic factors and molecular profiles of breast cancer. "
12/01/2011 - "BRCA1 protein expression and its correlation with ER/PR status in sporadic and familial breast cancer in Eastern Indian patients--a hospital based study."
03/01/2010 - "In the present investigation, immunohistological studies of BRCA1 protein in frozen breast cancer tissue and MCF7 and HeLa cell lines revealed BRCA1 expression in both nucleoli and nucleoplasmic foci. "
01/04/2001 - "In this study, we found that breast cancer-associated mutations of BRCA1 abolish or reduce its ability to inhibit ER-alpha activity and that domains within the amino- and carboxyl-termini of the BRCA1 protein are required for the inhibition. "
01/01/2015 - "In the first part of this review, we briefly discuss the function and regulation of the BRCA1 protein, including its role associated with familial and sporadic breast cancer. "
03/01/2014 - "Our study demonstrated that EGFR gene copy number status was not correlated with ERCC1 or BRCA1 protein expression, but ERCC1 protein levels were significantly correlated to BRCA1 protein expression levels in tumor tissues from Chinese patients with NSCLC."
01/01/2015 - "There is emerging evidence that BRCA1 gene product (BRCA1) also plays a role in cancer cell migration. "
08/01/2014 - "BRCA1 protein was detected in the nuclei and the cytoplasm of the tumor cells. "
12/01/2012 - "Similarly, downregulation of BRCA1 protein expression is observed in the majority of basal-like breast cancers. "
11/30/2012 - "In addition, reduced BRCA1 protein is associated with sporadic cancer cases in these tissues. "
01/01/2013 - "Our study illustrates that a low level of BRCA1 protein expression is a favorable prognostic indicator in USC, similar to what is observed in high-grade serous ovarian carcinoma. "
01/01/2013 - "The objective of this study was to investigate the relationship between BRCA1 protein expression, as determined by immunohistochemistry, and clinical outcome in uterine serous carcinoma (USC). "
01/01/2011 - "In the present experimental study we examined the expression and localization of the BRCA1 protein and investigated the prognostic value as well as its relationship with the putative cancer stem cell (CSC) marker (CD44) in 156 tumour samples from a well-characterized series of unselected breast carcinomas using immunohistochemistry. "
06/01/2008 - "The purpose of the current study was to examine the expression and localization of BRCA1 protein and to assess its prognostic value, in a well-characterized series of unselected breast carcinomas. "
08/01/2014 - "Our purpose was to investigate the expression pattern of BRCA1 protein in sporadic breast carcinomas, as well as the clinicopathological and prognostic value of its subcellular localizations. "
09/06/2002 - "Recent studies have shown that the BRCA1 gene product may be important in mediating responses to DNA damage and genomic instability. "
06/01/2007 - "Our results thus indicate that the genomic instability observed in normal cells from BRCA1 and BRCA2 mutation carriers is associated with a down-regulation of nuclear BRCA1 protein accumulation in the dot like structures. "
07/01/2006 - "These data support a model in which a structural modification in a critical domain of the BRCA1 gene product secondary to single amino acid mutations, may be able, per se, to impair the DNA damage response pathway, inducing genomic instability and eventually leading to breast carcinogenesis."
03/15/2011 - "Conditional doxycycline-induced upregulation of EZH2 in benign mammary epithelial cells results in nuclear export of BRCA1 protein, aberrant mitoses with extra centrosomes, and genomic instability. "
|1.||Proteins (Proteins, Gene)
|3.||Protein Isoforms (Isoforms)
|4.||Complementary DNA (cDNA)
|5.||Biological Markers (Surrogate Marker)
|1.||Drug Therapy (Chemotherapy)
|2.||Combination Drug Therapy (Combination Chemotherapy)