BRCA1 Protein

The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)

Also Known As:

Networked: 260 relevant articles (2 outcomes, 31 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Parvin, Jeffrey D: 5 articles (01/2022 - 06/2004)
2.	Swisher, Elizabeth M: 4 articles (12/2019 - 04/2008)
3.	Taniguchi, Toshiyasu: 4 articles (01/2016 - 04/2008)
4.	Rosen, Eliot M: 4 articles (01/2013 - 01/2003)
5.	Jonkers, Jos: 3 articles (01/2021 - 01/2016)
6.	Piwocka, Katarzyna: 3 articles (10/2018 - 05/2010)
7.	Brown, Melissa A: 3 articles (09/2018 - 10/2002)
8.	Privat, Maud: 3 articles (10/2017 - 06/2010)
9.	Couch, Fergus J: 3 articles (01/2016 - 06/2004)
10.	Wappenschmidt, Barbara: 3 articles (01/2016 - 09/2010)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 05/05/2010 - "Targets within this pathway could provide strategies for modulation of BRCA1 protein, which may prove therapeutically beneficial for breast and ovarian cancer treatment." 02/01/2004 - "To clarify the possible involvement of BRCA1 in the development of sporadic ovarian neoplasms, this study analysed the immunohistochemical expression of BRCA1 protein in normal ovarian surface epithelium and 119 epithelial ovarian tumours (19 benign, 24 borderline, and 76 malignant tumours). " 01/01/2021 - "Mutations in breast cancer type 1 susceptibility protein (BRCA1) and its heterodimeric binding partner BARD1 confer a high risk for the development of breast and ovarian cancers. " 01/01/2019 - "Loss-of-function mutations of the breast cancer type 1 susceptibility protein (BRCA1) are associated with breast (BC) and ovarian cancer (OC). " 06/15/2010 - "Here, we use biochemical and cell-based transcriptional assays to assess the structural and functional defects associated with a large set of 117 distinct BRCA1 missense variants within the essential BRCT domain of the BRCA1 protein that have been documented in individuals with a family history of breast or ovarian cancer. "
2.	Cardiomegaly (Heart Hypertrophy) 01/01/2016 - "MicroRNA-155 (miR-155) was found to be decreased in hypertrophic myocardium, which could be further reduced by pretreatment of Rev. The study was designed to investigate the molecular effects of miR-155 on cardiac hypertrophy, focusing on the role of breast cancer type 1 susceptibility protein (BRCA1). " 01/01/2016 - "Resveratrol Ameliorates Cardiac Hypertrophy by Down-regulation of miR-155 Through Activation of Breast Cancer Type 1 Susceptibility Protein."
3.	Breast Neoplasms (Breast Cancer) 04/01/2020 - "Immunohistochemical Expression of BRCA1 Protein, ER, PR and Her2/neu in Breast Cancer: A Clinicopathological Study." 01/01/2017 - "Further large-scale studies are required to assess the potential relevance of BRCA1 protein expression and localization in routine classification of breast cancer." 09/01/2012 - "This study aims to assess BRCA1 protein expression and the role of BRCA1 promoter methylation in sporadic breast cancer in North Indian population and to correlate these with known prognostic factors and molecular profiles of breast cancer. " 01/01/2011 - "In the present experimental study we examined the expression and localization of the BRCA1 protein and investigated the prognostic value as well as its relationship with the putative cancer stem cell (CSC) marker (CD44) in 156 tumour samples from a well-characterized series of unselected breast carcinomas using immunohistochemistry. " 03/01/2010 - "In the present investigation, immunohistological studies of BRCA1 protein in frozen breast cancer tissue and MCF7 and HeLa cell lines revealed BRCA1 expression in both nucleoli and nucleoplasmic foci. "
4.	Neoplasms (Cancer) 01/01/2022 - "In the present study we studied the hormonal profile in 303 sporadic breast cancers and BRCA1 protein expression in these patients along with its clinico-pathological correlation. " 01/01/2020 - "Preliminary studies suggest that higher tumor expression of the BRCA1 protein may be associated with worse prognosis. " 12/11/2019 - "In this study, we show that cell lines and patient-derived tumors, with highly disruptive BRCT domain mutations, have readily detectable BRCA1 protein expression, and are able to proliferate in the presence of PARPi. " 12/01/2023 - "BRCA1 protein expression was observed in 12% of primary and 19% of NACT-treated HG-SOC tumors. " 12/01/2023 - "We evaluated the expression pattern of BRCA1 protein by immunohistochemistry in 119 cases of HG-SOC from a hospital cohort consisting of primary (N = 69) and NACT-treated (N = 50) tumors. "
5.	Carcinoma (Carcinomatosis) 10/01/2023 - "The present study aimed to investigate the impact of BRCA1 protein expression on the patients' outcome of ovarian serous carcinoma, and its correlation with different clinicopathologic features. " 01/01/2013 - "The objective of this study was to investigate the relationship between BRCA1 protein expression, as determined by immunohistochemistry, and clinical outcome in uterine serous carcinoma (USC). " 05/01/2014 - "A subset of uterine serous carcinomas shows the loss of BRCA1 protein and is associated with germline mutation. " 05/01/2014 - "Immunohistochemical loss of BRCA1 protein in uterine serous carcinoma." 07/14/2009 - "Of 115 primary sporadic ovarian carcinomas, 39 (34%) had low BRCA1 protein and 49 (42%) had low BRCA2 expression. "

Related Drugs and Biologics

1.	Resveratrol
2.	Proteins (Proteins, Gene)
3.	Platinum
4.	Biomarkers (Surrogate Marker)
5.	Estrogens (Estrogen)
6.	Indicators and Reagents (Reagents)
7.	Survivin
8.	PPAR gamma
9.	HMGB1 Protein (HMG1)
10.	Protein Isoforms (Isoforms)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Neoadjuvant Therapy
4.	Combination Drug Therapy (Combination Chemotherapy)