2,4-Dinitrophenol (2,4 Dinitrophenol)

A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed)

Also Known As:

Networked: 270 relevant articles (8 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sullivan, Patrick G: 4 articles (01/2021 - 10/2004)
2.	Geisler, John G: 4 articles (10/2018 - 01/2017)
3.	Shulman, Gerald I: 3 articles (03/2015 - 07/2004)
4.	Henriques, Inês D S: 3 articles (09/2007 - 07/2005)
5.	Love, Nancy G: 3 articles (09/2007 - 07/2005)
6.	Han, Li: 2 articles (07/2021 - 07/2021)
7.	Wang, Fang: 2 articles (07/2021 - 07/2021)
8.	Yang, Ming: 2 articles (07/2021 - 07/2021)
9.	Zhang, Ding-Kun: 2 articles (07/2021 - 07/2021)
10.	Patel, Samir P: 2 articles (01/2021 - 01/2009)

Related Diseases

1.	Poisoning 12/01/2016 - "This study aimed to investigate the early changes of lymphocyte subpopulations in patients with occupational 2,4-DNP poisoning. " 01/05/2024 - "The authors present an original method to test for 2,4-dinitrophenol in hair after methanolic extraction using LC-MS/MS. The limit of detection of the procedure is 0.01 ng/mg and the method was fully validated in the range 0.1-50 ng/mg. 2,4-dinitrophenol tested positive in the brown hair of a subject deceased from acute poisoning at 5.15, 13.06 and 25.48 ng/mg in the 3 × 3 cm segments. " 12/01/2016 - "Totally 9 patients with acute occupational 2,4-DNP poisoning and 30 healthy volunteers as control were enrolled. " 12/01/2016 - "Early Changes of Peripheral Blood Lymphocyte Subpopulations in Patients with Occupational 2,4-dinitrophenol Poisoning." 08/01/2015 - "We reported 16 cases of acute 2,4-DNP poisoning through occupational exposure due to ignoring the risk of poisoning. "
2.	Fever (Fevers) 01/01/2022 - "Fed and fasted chicks at 25°C completely eliminated fever despite the ability to increase metabolic rate for thermogenesis in the phase correspondent to fever when it was pharmacologically induced by 2,4-dinitrophenol. " 01/01/2011 - "Metabolomic study of a rat fever model induced with 2,4-dinitrophenol and the therapeutic effects of a crude drug derived from Coptis chinensis." 10/01/1995 - "omeiensis and puerarin on the fever induced by 2,4-dinitrophenol in rats were very fast and significant, maintaining for about 8 hours, while the effect of P. " 10/01/1958 - "[The oxygen consumption of the diaphragm isolated from guinea pigs with fever induced by 2,4-dinitrophenol or by bacterial lipopolysaccharide]." 07/01/2021 - "Furthermore,the rat fever model induced by 2,4-dinitrophenol was used to study the antipyretic effect of IN in normal rats and bile duct ligation rats. "
3.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2018 - "2,4 Dinitrophenol Attenuates Mitochondrial Dysfunction and Improves Neurobehavioral Outcomes Postanoxia in Neonatal Rats." 03/01/2015 - "The cellular and molecular progression of mitochondrial dysfunction induced by 2,4-dinitrophenol in developing zebrafish embryos." 05/01/1993 - "NaCN and 2,4-dinitrophenol (DNP) caused a large elevation of [Ca2+]i, mitochondrial dysfunction, and cell death. " 01/01/2018 - "The present study investigated the role of 2,4 dinitrophenol (2,4 DNP) in three doses, i.e.,1, 2.5, and 5 mg/kg on anoxia-induced time-dependent mitochondrial dysfunction and associated neurobehavioral outcome using a well-established global model of anoxia. " 10/01/2018 - "This study utilizes a prodrug of 2,4-dinitrophenol, MP201, a mitochondrial uncoupler with extended elimination time, that was administered after TBI to target mitochondrial dysfunction, a hallmark of TBI. "
4.	Spinal Cord Injuries (Spinal Cord Injury) 10/01/2004 - "The purpose of this study was to investigate the potential neuroprotective efficacy of the mitochondrial uncoupler 2,4-dinitrophenol (DNP) in rats following a mild to moderate spinal cord contusion injury. " 01/01/2021 - "This study tested the hypothesis that mitochondria contribute to spinal cord injury (SCI)-induced neurodegeneration in an age-dependent manner by using 2,4-dinitrophenol (DNP) to uncouple electron transport, thereby increasing cellular respiration and reducing reactive oxygen species (ROS) production. " 01/01/2009 - "Differential effects of the mitochondrial uncoupling agent, 2,4-dinitrophenol, or the nitroxide antioxidant, Tempol, on synaptic or nonsynaptic mitochondria after spinal cord injury."
5.	Body Weight (Weight, Body) 05/01/2022 - "2,4 dinitrophenol (DNP) is a toxic industrial chemical that reduces body weight and body fat by uncoupling oxidative phosphorylation but at the risk of severe dose-related toxicity. " 01/01/2019 - "Cold stimulation of BAT has convincingly translated into humans, and older clinical observations with nonselective 2,4-DNP validate that human BAT's participation in pharmacologically mediated, though nonselective, mitochondrial membrane decoupling can provide increased energy expenditure and corresponding body weight loss. " 10/27/2017 - "A detailed medical interview revealed that the patient had been taking self-imported 2,4-dinitrophenol (DNP) for 2 months to decrease body weight. " 10/01/2017 - "The mitochondrial uncoupling agent 2,4-dinitrophenol (DNP), historically used as a treatment for obesity, is known to cross the blood-brain-barrier, but its effects on central neural circuits controlling body weight are largely unknown. " 11/01/1983 - "A single ip administration of 2,4-dinitrophenol (0.1 mg/100 g body weight), an inhibitor of oxidative phosphorylation, did not prevent significant increases in phosphorus contents of the homogenate and the mitochondria caused by administration of CT (80 MRC mU/100 g body weight), although the drug markedly inhibited ATPase activity in the mitochondria. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Reactive Oxygen Species (Oxygen Radicals)
3.	Glucose (Dextrose)
4.	Insulin (Novolin)
5.	Antioxidants
6.	Triglycerides (Triacylglycerol)
7.	DNA (Deoxyribonucleic Acid)
8.	tempol
9.	Adenosine Triphosphate (ATP)
10.	Cycloheximide (Cicloheximide)

Related Therapies and Procedures

1.	Hemoperfusion
2.	Bioreactors (Bioreactor)
3.	Ligation
4.	Injections
5.	Therapeutics