HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Wasting Syndrome (Wasting Disease)

A condition of involuntary weight loss of greater then 10% of baseline body weight. It is characterized by atrophy of muscles and depletion of lean body mass. Wasting is a sign of MALNUTRITION as a result of inadequate dietary intake, malabsorption, or hypermetabolism.
Also Known As:
Wasting Disease; Wasting Diseases; Wasting Syndromes
Networked: 640 relevant articles (13 outcomes, 51 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Acquired Immunodeficiency Syndrome (AIDS)
3. Hyponatremia
4. Inappropriate ADH Syndrome (SIADH)
5. Cachexia

Experts

1. Chae, C: 8 articles (09/2006 - 11/2000)
2. Pohjanvirta, Raimo: 7 articles (10/2015 - 01/2005)
3. Matsumura, Fumio: 7 articles (05/2015 - 03/2002)
4. Lindén, Jere: 6 articles (10/2015 - 01/2005)
5. Matsuo, Masafumi: 6 articles (09/2015 - 05/2006)
6. Ishii, Yuji: 6 articles (05/2015 - 05/2005)
7. Yamada, Hideyuki: 6 articles (05/2015 - 05/2005)
8. Segalés, J: 6 articles (09/2011 - 03/2003)
9. Segalés, Joaquim: 6 articles (07/2011 - 03/2002)
10. Mateu, Enric: 6 articles (07/2011 - 03/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Wasting Syndrome:
1. Tetrachlorodibenzodioxin (TCDD)IBA
2. Formaldehyde (Formol)FDA Link
07/01/1999 - "A comparison of in situ hybridization and immunohistochemistry for the detection of a new porcine circovirus in formalin-fixed tissues from pigs with post-weaning multisystemic wasting syndrome (PMWS)."
08/01/2005 - "The immunohistochemical method described was successfully applied to formalin-fixed, paraffin wax-embedded tissues and should prove helpful in diagnosing postweaning multisystemic wasting syndrome."
07/01/2014 - "The objective of the present study was to evaluate polyclonal- and monoclonal-antibody-based immunohistochemical (IHC) tests for the detection of 2 genotypes of Porcine circovirus type 2 (PCV2), a and b, in formalin-fixed, paraffin-embedded lymph-node tissue from pigs with experimental or natural postweaning multisystemic wasting syndrome and to compare the IHC results with those of in-situ hybridization (ISH) assays. "
03/01/2010 - "The aim of the current study was to develop a nonradioactive in situ hybridization assay that can differentiate between genotypes 2a and 2b of Porcine circovirus-2 (PCV-2) in formalin-fixed, paraffin-embedded lymph node tissues from pigs with postweaning multisystemic wasting syndrome. "
09/18/2009 - "Taking advantage of the high sensitivity of polymerase chain reaction (PCR) and the cell-localizing ability of in situ hybridization (ISH), an indirect in situ PCR (ISPCR) method was developed for detecting the distribution of porcine circovirus type 2 (PCV2) in formalin-fixed and paraffin-embedded inguinal lymph nodes obtained from clinically healthy PCV2-carrier pigs and postweaning multisystemic wasting syndrome (PMWS)-affected pigs. "
3. ParaffinIBA
08/01/2005 - "The immunohistochemical method described was successfully applied to formalin-fixed, paraffin wax-embedded tissues and should prove helpful in diagnosing postweaning multisystemic wasting syndrome."
07/01/2014 - "The objective of the present study was to evaluate polyclonal- and monoclonal-antibody-based immunohistochemical (IHC) tests for the detection of 2 genotypes of Porcine circovirus type 2 (PCV2), a and b, in formalin-fixed, paraffin-embedded lymph-node tissue from pigs with experimental or natural postweaning multisystemic wasting syndrome and to compare the IHC results with those of in-situ hybridization (ISH) assays. "
03/01/2010 - "The aim of the current study was to develop a nonradioactive in situ hybridization assay that can differentiate between genotypes 2a and 2b of Porcine circovirus-2 (PCV-2) in formalin-fixed, paraffin-embedded lymph node tissues from pigs with postweaning multisystemic wasting syndrome. "
09/18/2009 - "Taking advantage of the high sensitivity of polymerase chain reaction (PCR) and the cell-localizing ability of in situ hybridization (ISH), an indirect in situ PCR (ISPCR) method was developed for detecting the distribution of porcine circovirus type 2 (PCV2) in formalin-fixed and paraffin-embedded inguinal lymph nodes obtained from clinically healthy PCV2-carrier pigs and postweaning multisystemic wasting syndrome (PMWS)-affected pigs. "
07/01/2009 - "In situ hybridization and immunohistochemistry with different types of antibody (monoclonal vs. polyclonal, natural vs. synthetic) was compared to detect porcine circovirus 2 (PCV2) in formalin-fixed, paraffin-embedded tissues from pigs with experimentally and naturally occurring postweaning multisystemic wasting syndrome. "
4. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
5. MagnesiumIBA
6. Prednisone (Sone)FDA LinkGeneric
7. thymosin fraction 5IBA
8. SodiumIBA
9. SteroidsIBA
10. Cytochrome P-450 CYP1A1 (CYP1A1)IBA
05/01/2004 - "Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria."
01/01/2012 - "Neither wasting syndrome nor CYP1A1 induction in the fetal brain caused through the activation of aryl hydrocarbon receptor (AhR) could be attenuated by LA. "
05/01/2004 - "Using a single large intraperitoneal dose of TCDD (200 microg/kg) and following the response over an 8-week period, we found this dose: (a) was lethal in less than 4 weeks to Cyp1a1(+/+) males but not to Cyp1a1(-/-) males or to females of either genotype; (b) caused a wasting syndrome in Cyp1a1(+/+) but not Cyp1a1(-/-) mice; (c) resulted in thymic atrophy, regardless of gender or genotype; (d) decreased spleen size and caused leukocytopenia in males but not females of either genotype; (e) caused hepatocyte hypertrophy in Cyp1a1(+/+) more so than in Cyp1a1(-/-) mice; (f) increased intrahepatocyte lipids and total liver fat content in Cyp1a1(+/+) more than Cyp1a1(-/-) males and females; and (g) caused uroporphyria in Cyp1a1(+/+) males much more than Cyp1a1(+/+) females, or in Cyp1a1(-/-) mice. "
05/01/2015 - "Of PenCDF doses examined, wasting syndrome and oxidative stress took place most markedly in 5 mg/kg. In disagreement with this, EROD activity which is the marker of the aryl hydrocarbon receptor-dependent induction of cytochrome P450 1a1 was elevated most abundantly at 0.3 mg/kg. Then, we examined the effect of cynaropicrin on the wasting syndrome and oxidative stress provoked by PenCDF at 5 mg/kg. However, this compound up to 20 mg/kg (p.o.) did not attenuate PenCDF-induced wasting syndrome. "
05/01/2005 - "TCDD induces a broad spectrum of biological responses, including induction of cytochrome P-450 1A1 (CYP1A1), disruption of normal hormone signaling pathways, reproductive and developmental defects, immunotoxicity, liver damage, wasting syndrome, and cancer. "

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Transplants (Transplant)
3. Thymectomy
4. Highly Active Antiretroviral Therapy (HAART)
5. Intensive Care (Surgical Intensive Care)