Proto-Oncogene Proteins c-bcl-2 (Proto Oncogene Proteins c bcl 2)

Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.

Also Known As:

Proto Oncogene Proteins c bcl 2; B-Cell Leukemia 2 Family Proteins; BCL2 Family Proteins; BCL2 Proteins; B Cell Leukemia 2 Family Proteins; Family Proteins, BCL2; Proteins, BCL2; Proteins, BCL2 Family; Proto-Oncogene Proteins, bcl-2; bcl 2 Proto Oncogene Proteins; c bcl 2 Proteins; c-bcl-2, Proto-Oncogene Proteins; bcl-2 Proto-Oncogene Proteins; c-bcl-2 Proteins

Networked: 141 relevant articles (2 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2514
      - Proto-Oncogene Proteins c-bcl-2: 141
        bcl-2-Associated X Protein: 1405
        bcl-X Protein: 146
        Myeloid Cell Leukemia Sequence 1 Protein: 56
        bcl-Associated Death Protein: 32
        bcl-2 Homologous Antagonist-Killer Protein: 25
        BH3 Interacting Domain Death Agonist Protein: 24
        BCL2-related protein A1: 2
        BCL2-like 10 protein
        C elegans Ced-9 protein
        chicken Nr13 protein
        Drosophila Buffy protein
        Geodia cydonium bhp2 protein
        human Bcl-2psi protein
        human BCL2 protein
        human BCL2L12 protein
        human BCL2L13 protein
        human BCL2L14 protein
        human BCL2L15 protein
        human BNIP1 protein
        human BOK protein
        human PMAIP1 protein
        mouse Bcl2 protein
        mouse Bcl2l12 protein
        mouse BCL2L13 protein
        mouse BCL2L14 protein
        mouse Bcl2l15 protein
        mouse Bok protein
        mouse Pmaip1 protein
        rat Bcl2 protein
        rat Bcl2l13 protein
        rat Bcl2l2 protein
        rat Bnip2 protein
        rat Pmaip1 protein
        zebrafish bcl2a protein
        zebrafish pmaip1 protein
  - Neoplasm Proteins: 2
    - Oncogene Proteins: 7793
      - Proto-Oncogene Proteins: 7
        Proto-Oncogene Proteins c-bcl-2: 141
        Myeloid Cell Leukemia Sequence 1 Protein: 56
        BCL2-related protein A1: 2
        BCL2-like 10 protein
        C elegans Ced-9 protein
        chicken Nr13 protein
        Drosophila Buffy protein
        Geodia cydonium bhp2 protein
        human Bcl-2psi protein
        human BCL2 protein
        human BCL2L12 protein
        human BCL2L13 protein
        human BCL2L14 protein
        human BCL2L15 protein
        human BNIP1 protein
        human BOK protein
        human PMAIP1 protein
        mouse Bcl2 protein
        mouse Bcl2l12 protein
        mouse BCL2L13 protein
        mouse BCL2L14 protein
        mouse Bcl2l15 protein
        mouse Bok protein
        mouse Pmaip1 protein
        rat Bcl2 protein
        rat Bcl2l13 protein
        rat Bcl2l2 protein
        rat Bnip2 protein
        rat Pmaip1 protein
        zebrafish bcl2a protein
        zebrafish pmaip1 protein
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2514
      - Proto-Oncogene Proteins c-bcl-2: 141
        bcl-2-Associated X Protein: 1405
        bcl-X Protein: 146
        Myeloid Cell Leukemia Sequence 1 Protein: 56
        bcl-Associated Death Protein: 32
        bcl-2 Homologous Antagonist-Killer Protein: 25
        BH3 Interacting Domain Death Agonist Protein: 24
        BCL2-related protein A1: 2
        BCL2-like 10 protein
        C elegans Ced-9 protein
        chicken Nr13 protein
        Drosophila Buffy protein
        Geodia cydonium bhp2 protein
        human Bcl-2psi protein
        human BCL2 protein
        human BCL2L12 protein
        human BCL2L13 protein
        human BCL2L14 protein
        human BCL2L15 protein
        human BNIP1 protein
        human BOK protein
        human PMAIP1 protein
        mouse Bcl2 protein
        mouse Bcl2l12 protein
        mouse BCL2L13 protein
        mouse BCL2L14 protein
        mouse Bcl2l15 protein
        mouse Bok protein
        mouse Pmaip1 protein
        rat Bcl2 protein
        rat Bcl2l13 protein
        rat Bcl2l2 protein
        rat Bnip2 protein
        rat Pmaip1 protein
        zebrafish bcl2a protein
        zebrafish pmaip1 protein

Experts

1.	Prehn, Jochen H M: 4 articles (01/2021 - 01/2013)
2.	Lucantoni, Federico: 3 articles (01/2021 - 05/2018)
3.	Eastman, Alan: 3 articles (08/2020 - 01/2016)
4.	Dyer, Martin J S: 3 articles (01/2017 - 05/2011)
5.	Vogler, Meike: 3 articles (01/2017 - 05/2011)
6.	Agnantis, Niki John: 3 articles (01/2007 - 07/2004)
7.	Bai, Maria: 3 articles (01/2007 - 07/2004)
8.	Kanavaros, Panagiotis: 3 articles (01/2007 - 07/2004)
9.	Byrd, John C: 2 articles (01/2021 - 02/2016)
10.	Fresquet, Vicente: 2 articles (01/2021 - 06/2014)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 03/20/2023 - "Therapeutic targeting of the apoptotic process in breast cancer sub-types will be improved by a detailed understanding of the core players in the process, including anti-apoptotic BCL2 family proteins. " 12/30/2022 - "Breast cancer cell line models faithfully depict the most common molecular aberration in BCL2 family proteins observed in clinical breast cancer samples, MCL1 amplifications. " 12/30/2022 - "Molecular alterations in anti-apoptotic BCL2 family proteins in breast cancer cell line models, drug sensitivities and dependencies to guide the development of BCL2 inhibitors." 01/01/2020 - "To predict the survival outcomes of invasive breast cancer in Vietnam, using immunohistochemical expression of p53, Bcl2 proteins. " 09/01/1999 - "We studied 138 operable breast cancer patients in order to verify the relationships of p53 and bcl2 proteins with better known clinicopathological features and their impact on the clinical outcomes of relapse-free survival (RFS) and overall survival (OS). "
2.	Hematologic Neoplasms (Hematological Malignancy) 07/01/2020 - "Targeting anti-apoptotic pathways involving the BCL2 family proteins represents a novel treatment strategy in hematologic malignancies. " 09/01/2013 - "For all these reasons, the opportunity to induce apoptosis by targeting BCL2 proteins is considered a potentially promising therapeutic approach in hematological malignancies. " 01/01/2022 - "Overexpression of antiapoptotic BCL2 family proteins occurs in various hematologic malignancies and contributes to tumorigenesis by inhibiting the apoptotic machinery of the cells. "
3.	Neoplasms (Cancer) 06/26/2014 - "Our study reveals the acquisition of mutations in BCL2 family proteins as a novel mechanism of apoptosis resistance in cancer. " 12/01/2023 - "Targeting BCL2 family proteins to induce cancer cell death has been successful in the treatment of cancer. " 06/01/2023 - "Evasion of programmed cell death (apoptosis) is a hallmark of cancer cells and direct induction of apoptosis by targeting the pro-survival BCL2 family proteins represents a promising therapeutic strategy for cancer treatment. " 01/01/2023 - "In contrast, this homeostasis is frequently perturbed in cancer cells due to the overexpression of anti-apoptotic BCL2 family proteins. " 02/01/2022 - "Suppression of multiple anti-apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms."
4.	Leukemia 01/01/2023 - "The deregulation of BCL2 family proteins plays a crucial role in leukemia development. " 01/01/2020 - "Studies of leukemia cell line sensitivity identify mixed lineage leukemia (MLL) gene status and the level of B-cell lymphoma 2 (BCL2) family proteins as potential markers for selection of patients with greater sensitivity to fadraciclib. " 03/01/2017 - "Therefore, in the present study, we assessed whether BCL2 family proteins mediated the cytotoxic effects of amsacrine on human leukemia U937 cells. " 01/01/2019 - "These results demonstrate a remarkable role of 4t- CHQ in arresting leukemia KG1-a stem cells both by induction of apoptosis as well as by down-regulating survivin and Bcl2 proteins." 12/01/1998 - "To elucidate the molecular mechanisms underlying this inhibitory effect of VEGF, we examined expression levels of BCL2 family proteins in CMK86, a human leukemia cell line, after treatment with VEGF. "
5.	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 10/01/2009 - "This study was conducted to analyze the frequency, expression patterns, and the impact of individual proteins BCL2, BCL6, and p53 on overall survival (OS) in adult, diffuse large B-cell lymphoma (DLBCL) patients. " 01/01/2016 - "Dual expression of MYC and BCL2 proteins predicts worse outcomes in diffuse large B-cell lymphoma." 01/01/2023 - "Double expressor lymphoma (DEL) is a subset of diffuse large B-cell lymphoma (DLBCL) characterized by the co-expression of MYC and BCL2 proteins with a poor prognosis. " 01/01/2023 - "Data are limited regarding the genetic profiling of diffuse large B-cell lymphoma (DLBCL) with double expression of MYC and BCL2 proteins without underlying rearrangements (double-expressor lymphoma [DEL]). " 01/01/2022 - "Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, including one-third of cases overexpressing MYC and BCL2 proteins (double expressor lymphoma, DEL) and 5-10% of patients with chromosomal rearrangements of MYC, BCL2 and/or BCL-6 (double/triple-hit lymphomas, DH/TH). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Caspase 3 (Caspase-3)
3.	Caspases
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
6.	Cytokines
7.	Cisplatin (Platino)
8.	Amsacrine (AMSA)
9.	navitoclax
10.	carboxyl radical (COO-)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)