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HIV Wasting Syndrome

Involuntary weight loss of greater than 10 percent associated with intermittent or constant fever and chronic diarrhea or fatigue for more than 30 days in the absence of a defined cause other than HIV infection. A constant feature is major muscle wasting with scattered myofiber degeneration. A variety of etiologies, which vary among patients, contributes to this syndrome. (From Harrison's Principles of Internal Medicine, 13th ed, p1611).
Also Known As:
Wasting Syndrome, AIDS; AIDS Wasting Syndrome; HIV Wasting Disease; Slim Disease; Wasting Disease, HIV; Wasting Syndrome, HIV
Networked: 49 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Acquired Immunodeficiency Syndrome (AIDS)
2. Vomiting
3. Nausea
4. Multiple Sclerosis
5. Glaucoma

Experts

1. Lee, Byung-Mu: 1 article (11/2015)
2. Choi, Seul Min: 1 article (11/2015)
3. Guzman, M: 1 article (06/2015)
4. Abrams, D I: 1 article (06/2015)
5. Parry, Charles D H: 1 article (06/2014)
6. Myers, Bronwyn J: 1 article (06/2014)
7. Flisiak, Robert: 1 article (10/2013)
8. Parfieniuk-Kowerda, Anna: 1 article (10/2013)
9. Jaroszewicz, Jerzy: 1 article (10/2013)
10. Grzeszczuk, Anna: 1 article (10/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to HIV Wasting Syndrome:
1. CannabinoidsIBA
2. Testosterone (Sustanon)FDA Link
3. Thalidomide (Thalomid)FDA Link
4. Human Growth Hormone (Saizen)FDA LinkGeneric
5. Nandrolone (Nortestosterone)IBA
6. Zidovudine (Retrovir)FDA LinkGeneric
11/01/1995 - "The most simple classification of muscular disorders in HIV-infected patients is 1) HIV-associated myopathies, 2) zidovudine myopathy, 3) HIV wasting syndrome, and 4) opportunistic infections and tumoral infiltrations of muscle. "
06/01/1995 - "Tumor necrosis factor-alpha (TNF) may activate human immunodeficiency virus (HIV), antagonize zidovudine activity, and contribute to AIDS wasting syndrome. "
06/01/1994 - "We usually classify muscle involvement in HIV-infected patients in one of the following categories: (1) HIV-associated myopathy, a myopathy that meets the criteria for polymyositis in a majority of patients, and those for acquired nemaline myopathy in some; (2) zidovudine myopathy, a reversible mitochondrial myopathy; (3) the HIV-wasting syndrome and other AIDS-associated cachexias; (4) opportunistic infections and tumoral infiltrations of skeletal muscle; (5) vasculitic processes and iron pigment deposits. "
11/01/1995 - "We usually classify muscle involvement in HIV-infected patients in one of the following categories: (1) HIV-associated myopathy, a myopathy that meets the criteria for polymyositis in a majority of patients, and those for acquired nemaline myopathy in some; (2) zidovudine myopathy, a reversible mitochondrial myopathy; (3) the HIV-wasting syndrome and other AIDS-associated cachexias; (4) opportunistic infections and tumoral infiltrations of the skeletal muscle; (5) vasculitic processes and iron pigment deposits; (6) HIV-associated myasthenia gravis and (7) rhabdomyolysis. "
01/01/1997 - "We usually classify muscle involvement in HIV-infected patients in one of the following categories: HIV-associated myopathy, a myopathy that meets the criteria for polymyositis in a majority of patients, and those for acquired nemaline myopathy in some cases (1); zidovudine myopathy, a reversible mitochondrial myopathy (2); HIV-wasting syndrome and other AIDS-associated cachexias (3); opportunistic infections and tumor infiltrations of the skeletal muscle (4); vasculitic processes and iron pigment deposits (5); HIV-associated myasthenia gravis (6) and rhabdomyolysis (7). "
7. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
8. IronIBA
06/01/1994 - "We usually classify muscle involvement in HIV-infected patients in one of the following categories: (1) HIV-associated myopathy, a myopathy that meets the criteria for polymyositis in a majority of patients, and those for acquired nemaline myopathy in some; (2) zidovudine myopathy, a reversible mitochondrial myopathy; (3) the HIV-wasting syndrome and other AIDS-associated cachexias; (4) opportunistic infections and tumoral infiltrations of skeletal muscle; (5) vasculitic processes and iron pigment deposits. "
11/01/1995 - "We usually classify muscle involvement in HIV-infected patients in one of the following categories: (1) HIV-associated myopathy, a myopathy that meets the criteria for polymyositis in a majority of patients, and those for acquired nemaline myopathy in some; (2) zidovudine myopathy, a reversible mitochondrial myopathy; (3) the HIV-wasting syndrome and other AIDS-associated cachexias; (4) opportunistic infections and tumoral infiltrations of the skeletal muscle; (5) vasculitic processes and iron pigment deposits; (6) HIV-associated myasthenia gravis and (7) rhabdomyolysis. "
01/01/1997 - "We usually classify muscle involvement in HIV-infected patients in one of the following categories: HIV-associated myopathy, a myopathy that meets the criteria for polymyositis in a majority of patients, and those for acquired nemaline myopathy in some cases (1); zidovudine myopathy, a reversible mitochondrial myopathy (2); HIV-wasting syndrome and other AIDS-associated cachexias (3); opportunistic infections and tumor infiltrations of the skeletal muscle (4); vasculitic processes and iron pigment deposits (5); HIV-associated myasthenia gravis (6) and rhabdomyolysis (7). "
9. Insulin-Like Growth Factor I (IGF-1)IBA
10. Interleukin-1alpha (Interleukin 1 alpha)IBA

Therapies and Procedures

1. Analgesia
2. Highly Active Antiretroviral Therapy (HAART)
3. Drug Therapy (Chemotherapy)
4. Hormone Replacement Therapy (Therapy, Hormone Replacement)