Troponin C

A TROPONIN complex subunit that binds calcium and help regulate calcium-dependent muscle contraction. There are two troponin C subtypes: troponin C1 and C2. Troponin C1 is skeletal and cardiac type whereas troponin C2 is skeletal type. Troponin C1 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin C1 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.

Also Known As:

Networked: 138 relevant articles (3 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Parvatiyar, Michelle S: 10 articles (04/2021 - 08/2008)
2.	Pinto, Jose R: 10 articles (01/2021 - 08/2008)
3.	Sykes, Brian D: 9 articles (10/2015 - 08/2002)
4.	Potter, James D: 8 articles (09/2012 - 05/2004)
5.	Li, Monica X: 7 articles (10/2015 - 08/2002)
6.	Landim-Vieira, Maicon: 6 articles (04/2021 - 01/2016)
7.	Pinto, Jose Renato: 6 articles (04/2021 - 07/2009)
8.	Solaro, R John: 5 articles (12/2022 - 10/2003)
9.	Chase, P Bryant: 5 articles (04/2021 - 01/2017)
10.	Johnston, Jamie R: 5 articles (04/2021 - 04/2017)

Related Diseases

1.	Heart Failure 08/01/2011 - "Cardiac troponin C (cTnC) is the Ca²⁺ dependent switch for contraction in heart muscle making it a potential target for drug research in the therapy of heart failure. " 08/23/2002 - "Cardiac troponin C (cTnC) is the Ca(2+)-dependent switch for contraction in heart muscle and a potential target for drugs in the therapy of heart failure. " 01/01/1995 - "Calcium sensitization via troponin-C: a new approach for the treatment of heart failure. " 05/09/2000 - "Cardiac troponin C (cTnC) is the calcium-dependent switch for contraction in heart muscle and a potential target for drugs in the therapy of congestive heart failure. " 01/01/2018 - "This avoids Ca2+ overload that leads to arrhythmias and myocyte injuries, and do not increase the energy consumption for handling Ca2+ and has shown good activity against congestive heart failure (CHF), due to its increased myocardial contractility by stabilizing the calcium bound conformation of troponin C. "
2.	Acidosis 03/01/2013 - "The electrostatic interaction between residues E15 and E19 in troponin C and H162 in TnI at low pH is responsible for stabilizing the conformation of troponin C that leads to contraction, thus partially ablating the decreased Ca(2+)-sensitivity caused by acidosis." 01/01/1998 - "The decrease in the Ca2+ binding to troponin C explains the decrease in tetanic and twitch contraction, and mechanical stress applied to the preparation induced less [Ca2+]i change in acidosis." 01/01/1998 - "Acidosis decreased the normalized extra Ca2+ to [Ca2+]i immediately before the length change, which indicates that the amount of Ca2+ bound to troponin C is less when [Ca2+]i is the same as in the control. " 10/01/1993 - "Skeletal troponin C reduces contractile sensitivity to acidosis in cardiac myocytes from transgenic mice." 03/13/1989 - "Effect of acidosis on Ca2+ sensitivity of skinned cardiac muscle with troponin C exchange. "
3.	Neoplasms (Cancer) 07/31/2020 - "In this study, we describe a novel function of TNNC1 (Troponin C1, Slow Skeletal and Cardiac Type), a component of actin-bound troponin, as a tumor suppressor of lung adenocarcinoma (LUAD). " 08/31/2023 - "Compared to survivors, non-survivor patients were significantly (p < 0.05) older, exhibited significantly greater comorbidities and prevalence of active malignancy, heart failure, and arrhythmias, and showed significantly higher circulating levels of B-type natriuretic peptide, troponin, C-reactive protein, and d-dimer, as well as a longer heart-rate-corrected QT interval and significantly lower values for the glomerular filtration rate. "
4.	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/14/2011 - "This spectroscopic study examined the steady-state and kinetic parameters governing the cross-bridge effect on the increased Ca(2+) affinity of hypertrophic cardiomyopathy-cardiac troponin C (HCM-cTnC) mutants. " 06/15/2010 - "In this study, we investigated the effects of hypertrophic cardiomyopathy-linked mutations A8V, E134D, and D145E in cardiac troponin C on the properties of the C-domain sites. " 11/01/2009 - "The present study investigates the effects of the first mutation of troponin C (hcTnC(L29Q)) found in a patient with hypertrophic cardiomyopathy (HCM) on force-pCa relations and the interplay with phosphorylation of sarcomeric PKA substrates. " 07/10/2009 - "A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy." 12/01/2022 - "The effect of Mg2+ on Ca2+ binding to cardiac troponin C in hypertrophic cardiomyopathy associated TNNC1 variants."
5.	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 06/04/2010 - "In this study we explore the mechanisms by which a double mutation (E59D/D75Y) in cardiac troponin C (CTnC) associated with dilated cardiomyopathy reduces the Ca(2+)-activated maximal tension of cardiac muscle. " 08/02/2023 - "On the other hand, the engineered troponin C mutants (I61Q and D73N), genetically introduced into mouse myocardium, demonstrate that Ca2+ desensitization under basal conditions may be a driving factor for dilated cardiomyopathy. " 01/01/2021 - "Dilated Cardiomyopathy Mutations and Phosphorylation disrupt the Active Orientation of Cardiac Troponin C." 01/01/2015 - "Knock-in mice harboring a Ca(2+) desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy." 04/01/2014 - "Biochemical characterisation of Troponin C mutations causing hypertrophic and dilated cardiomyopathies."

Related Drugs and Biologics

1.	Troponin I
2.	Calcium
3.	Simendan (Levosimendan)
4.	Type 3 Cyclic Nucleotide Phosphodiesterases
5.	Potassium
6.	Adenosine Triphosphate (ATP)
7.	Adrenergic Agonists (Adrenergic Receptor Agonist)
8.	Proteins (Proteins, Gene)
9.	Brain Natriuretic Peptide (Natrecor)
10.	fibrin fragment D (D-dimer)

Related Therapies and Procedures

1.	Therapeutics
2.	Intranasal Administration