|1.||Albanes, Demetrius: 129 articles (11/2015 - 01/2002)|
|2.||Virtamo, Jarmo: 119 articles (12/2014 - 01/2002)|
|3.||Weinstein, Stephanie J: 58 articles (11/2015 - 03/2005)|
|4.||Taylor, Philip R: 54 articles (12/2014 - 01/2002)|
|5.||Virtamo, J: 31 articles (09/2013 - 01/2000)|
|6.||Albanes, D: 31 articles (09/2013 - 01/2000)|
|7.||Pietinen, Pirjo: 29 articles (06/2007 - 04/2002)|
|8.||Männistö, Satu: 26 articles (08/2015 - 12/2003)|
|9.||Stolzenberg-Solomon, Rachael Z: 25 articles (08/2015 - 05/2002)|
|10.||Wright, Margaret E: 17 articles (12/2014 - 02/2003)|
05/01/1994 - "The dietary administration of beta-carotene (BC; 100 mg/kg food) daily has been found to be highly effective in reducing cancer incidence in male Sprague-Dawley rats fed 2-acetyl-aminofluorene (0.05% in food). "
09/01/2009 - "None of the intervention studies supported a significant reduction in cancer risk with carotenoid (beta-carotene) supplementation. "
01/01/1988 - "Animals fed beta-carotene demonstrated a smaller but statistically significant reduction in tumor number and size. "
01/01/1985 - "Available evidence thus suggests that factors associated with green and yellow vegetables provides modest protection against certain forms of cancer; beta-carotene is a likely candidate and is the focus of considerable research activity. "
09/01/2002 - "In preclinical animal studies, beta-carotene had been effective against some chemically induced cancers, but not against tumors in the respiratory tract. "
|2.||Lung Neoplasms (Lung Cancer)
04/15/1999 - "In epidemiological studies, supplements of beta-carotene, which is abundant in fruits and vegetables, were not found to be beneficial in reducing the incidence of lung cancer in high-risk groups. "
07/01/1994 - "Supplementation did not result in a significant reduction in lung cancer, and a higher incidence of lung cancer was observed in the group receiving beta-carotene. "
02/01/2000 - "All three trials concluded that beta-carotene provided no protection against lung cancer; however, quite unexpectedly, two of the trials found a higher risk for lung cancer for those subjects given beta-carotene compared with those that were not. "
04/01/2002 - "Is residual confounding a reasonable explanation for the apparent protective effects of beta-carotene found in epidemiologic studies of lung cancer in smokers?"
06/01/2010 - "A meta-analysis of four randomised trials in a total of 109 394 subjects showed a statistically significant increase in the risk of lung cancer among smokers who used dietary supplements containing beta-carotene, at a mean dose of 20 to 30 mg/day. "
|3.||Cardiovascular Diseases (Cardiovascular Disease)
01/01/2001 - "There is some evidence from observational studies of an inverse association between beta-carotene and cardiovascular disease, particularly in smokers. "
02/01/1999 - "Available data from several completed large-scale randomized trials indicate that beta-carotene supplementation for durations up to 12 years has no overall benefit in well-nourished populations on the incidence of cardiovascular disease or the middle-to-late stages of carcinogenesis. "
07/01/1996 - "For cardiovascular disease, observational studies are less numerous but do point to a protective effect of high beta-carotene intake. "
12/01/1995 - "Although the epidemiologic evidence is consistent with a protective association between beta-carotene and cardiovascular disease, findings from the first single intervention trial conducted in a large free-living population cast doubts on the utility of beta-carotene for all high-risk populations. "
11/01/2003 - "No increase in the death from cardiovascular diseases was observed among patients treated with beta-carotene. "
01/01/1992 - "The results of this study show the fair efficacy of beta-carotene against oral leukoplakias, but further confirmations through controlled clinical studies are needed."
12/31/1993 - "We have evaluated the clinical efficacy of beta-carotene, given 30 mg/day orally, for treatment of oral leukoplakia patients. "
12/01/1999 - "Beta-carotene produces sustained remissions in patients with oral leukoplakia: results of a multicenter prospective trial."
09/01/1993 - "Early results are promising in that beta-carotene, alone or in combination with other nutrients, can reverse oral leukoplakia without toxicity in short-term trials. "
01/01/1992 - "In 1989, a phase II study of patients showing oral leukoplakias and treated with beta-carotene (90 mg/day) was begun. "
05/01/2004 - "The aims of the present study were to investigate the uptake, accumulation, and metabolism of beta-carotene by the human breast carcinoma cell line MCF-7. "
07/01/2005 - "The remaining cell lines (an SV40 transformed colon cell line, a small intestinal carcinoma cell line and several lung cell lines) had medium or high intracellular beta-carotene levels. "
12/01/2001 - "In summary, beta-carotene can inhibit growth of human colon carcinoma cells in vitro by induction of apoptosis in proliferating cells."
12/01/2001 - "Beta-carotene inhibits growth of human colon carcinoma cells in vitro by induction of apoptosis."
11/01/1999 - "These prespecified subgroup analyses appeared to support the idea that beta-carotene supplementation may reduce risk of prostate carcinoma among those with low baseline levels. "
|1.||Vitamin A (Retinol)
|3.||Ascorbic Acid (Vitamin C)
|2.||Drug Therapy (Chemotherapy)