|1.||beta-Thalassemia (Cooley's Anemia)
|2.||Hemochromatosis (Bronze Diabetes)
|5.||Sickle Cell Anemia (Hemoglobin S Disease)
|1.||Barton, James C: 49 articles (12/2015 - 02/2003)|
|2.||Camaschella, Clara: 42 articles (04/2015 - 05/2002)|
|3.||Adams, Paul C: 40 articles (08/2015 - 02/2003)|
|4.||Brissot, Pierre: 40 articles (02/2015 - 01/2002)|
|5.||Ganz, Tomas: 38 articles (10/2015 - 11/2002)|
|6.||Wood, John C: 36 articles (09/2015 - 03/2004)|
|7.||Porter, John B: 36 articles (09/2015 - 06/2002)|
|8.||Nemeth, Elizabeta: 35 articles (10/2015 - 04/2003)|
|9.||Acton, Ronald T: 34 articles (12/2015 - 02/2003)|
|10.||Loréal, Olivier: 32 articles (02/2015 - 01/2002)|
12/05/2014 - "Several studies have shown that targeting iron absorption could be beneficial in reducing or preventing iron overload in these 2 disorders, with promising preclinical data. "
06/01/2015 - "Conclusion DFX significantly improved iron metabolism in HD patients with iron overload and had an acceptable frequency of adverse effects. "
02/01/2014 - "Primary endpoint was regarded as significant improvement in the severity of liver and cardiac iron overload in severe and moderate cases, in addition to improvement or maintenance of the grade of severity in patients with mild iron overload or normal iron accumulation. "
06/10/2011 - "Iron-chelating therapy results in a significant improvement in the life expectancy of patients with transfusional iron overload. "
01/01/2008 - "There was a significant difference in disease-free and overall survival (35.8 and 27% in the iron overload group vs. 80.6 and 54.6% in the iron non-overload group; p = 0.01 and 0.03, respectively). "
|2.||Deferoxamine (Desferal)FDA LinkGeneric
03/01/2006 - "Intermittent very high-dose intravenous deferoxamine is practical, safe, and effective in managing iron overload in children. "
10/01/2001 - "Intravenous administration of high-dose deferoxamine over 48 h per week using a portable pump and implanted chamber improved compliance in two thalassemic adult patients, resulting in a significant decrease in iron overload. "
01/01/1999 - "Therapy with the chelator device having immobilized desferrioxamine should be beneficial for treatment of patients with iron overload."
06/06/1987 - "Subcutaneous desferrioxamine, though effective in preventing or reducing iron overload in transfusion-dependent refractory anaemia, is expensive and inconvenient. "
10/08/1983 - "Only one compound, deferrioxamine B, has been shown to be clinically effective and well tolerated in humans suffering from chronic iron overload. "
01/01/2012 - "We report two patients who achieved a marked improvement of hematopoiesis with the use of deferasirox (DSX) for transfusional iron overload. "
12/01/2013 - "Efficacy of Deferasirox for the treatment of iron overload in Chinese thalassaemia major patients: results from a prospective, open-label, multicentre clinical trial."
05/01/2012 - "In conclusion, our data suggest that oral deferasirox treatment may be used as a safe and effective alternative method for reducing iron overload in alloHSCT recipients, whether combined with or without phlebotomy."
06/01/2010 - "Although the number of subjects is small, deferasirox may be a safe and effective alternative for allogeneic HCT survivors with iron overload who cannot undergo phlebotomy."
07/01/2013 - "In this review, we report the results of different studies testing safety and efficacy of deferasirox in MDS patients, side effects associated with the drug, and suggested management of iron overload."
01/01/2009 - "In recent years advances in knowledge of iron overload patho-physiopathology, improvement and diffusion of diagnostic capability together with the development of new effective and safe oral chelators promise to further increase success of medical therapy. "
01/01/2015 - "Recent advances in imaging techniques and chelators development remarkably improved cardiac iron overload detection and treatment, respectively. "
01/01/2004 - "Clinical trials of the antitumor activity of chelators have been largely limited to DFO, which has been extensively studied as a consequence of its approved use for treatment of secondary iron overload. "
08/01/1995 - "This study presents new data favoring the potential clinical interest of this new class of chelating agents in the treatment of human iron overload."
07/01/2014 - "Collated data are presented on the pathophysiological impact of iron overload; measuring techniques and chelating agents' therapy positive impact on hematological status and overall survival are discussed. "
11/01/2010 - "This study evaluated the safety and efficacy of a new liquid formulation of deferiprone for the treatment of transfusional iron overload in children 1-10 years old. "
11/01/2010 - "The safety, tolerability, and efficacy of a liquid formulation of deferiprone in young children with transfusional iron overload."
11/01/2010 - "The results of this study show a favorable benefit/risk ratio of deferiprone oral solution for the treatment of young children with transfusional iron overload."
03/01/2010 - "The aims of this study were to investigate the efficacy and safety of deferiprone in a variety of pediatric hematologic and/or oncologic patients with a high iron overload. "
02/01/1997 - "Clinical trials are in progress in many centers worldwide that will provide further information on the long-term effectiveness of deferiprone as well as on the incidence of serious adverse effects in patients with iron overload. "
06/01/2014 - "This study shows that DFX is effective in reducing S-ferritin and LIC level in transfusional iron overload patients with MDS or AA and is well tolerated. "
03/01/2014 - "Eighteen months later, serum ferritin was reduced to 680 μg/L, while both liver and cardiac MRI T2* values improved, reflecting lower iron overload. "
01/01/2015 - "The present study aimed to fill that gap and assess the value of ferritin in the diagnosis of iron overload and deficiency. "
08/29/2013 - "Future studies in this population should use LIC to define iron overload instead of ferritin. "
09/01/2012 - "Recent studies using T2* MRI revealed that serum ferritin does not reflect the severity of iron overload in nontransfused TI patients. "
|7.||Isoflurophate (DFP)FDA Link
09/01/2013 - "In this analysis, DFP appeared to be the most cost-effective treatment available for managing chronic iron overload in β-thalassaemia patients. "
03/01/2011 - "DFP therapy alone improved iron overload and oxidative stress and compliance was good. "
01/01/2014 - "There is currently insufficient evidence to show that DFP is superior to DFO in the treatment of iron overload. "
07/01/2010 - "This study showed that the administration of DFO for 5 d a wk in combination with daily administration of DFP at 75 mg/Kg seemed to be the most efficacy and rapid method for reducing iron overload at liver and heart level. "
01/01/2013 - "Among the patients with myocardial iron overload at baseline, the changes in the global heart T2* and in biventricular function were not significantly different in DFP+DFO compared with the DFP group. "
|8.||Transferrin (beta 2 Transferrin)IBA
01/01/2000 - "Among C282Y/C282Y probands, significantly greater values of MCV (but not other erythrocyte parameters) occurred among those who had transferrin saturation values of 75% or greater or iron overload at diagnosis. "
08/01/2002 - "The aim of this study was to compare, in a hospital referral clinic, the reliability of transferrin saturation and UIBC for detection of subjects who have inherited HFE (HLA-asociated iron overload) genotypes predisposing to iron overload. "
04/01/1994 - "In the second study, 49 black Africans with iron overload were divided into those with or without an elevated transferrin saturation. "
05/01/2015 - "Increasing serum transferrin to reduce tissue iron overload due to ineffective erythropoiesis."
02/01/2015 - "These cases emphasize the usefulness of serum transferrin determination in the diagnostic evaluation of iron overload and the importance for clinicians to be aware of this syndrome. "
03/01/2013 - "This difference could not be explained by different hemoglobin levels, cardiac iron overload, and systolic blood pressure. "
12/01/1990 - "One patient with PNH showed an increase of hemoglobin from 89 to 139 g/liter that permitted monthly phlebotomies to reduce his iron overload. "
01/01/1990 - "Two Chinese patients with hemoglobin (Hb) H disease without a history of blood transfusion developed iron overload at the age of 45 and 53 years, respectively. "
12/01/2012 - "Erythrocytapheresis (ECP), automated red blood cell exchange, is increasingly being used for chronic transfusion therapy in sickle cell disease (SCD) as it is an isovolumetric transfusion, is more effective in lowering hemoglobin (Hb)S, and can limit iron overload. "
10/01/2007 - "Determinants and characteristics of mean corpuscular volume and hemoglobin concentration in white HFE C282Y homozygotes in the hemochromatosis and iron overload screening study."
|10.||Ribavirin (Virazole)FDA LinkGeneric
08/01/2005 - "Peginterferon/ribavirin was effective in thalassaemics with HCV and moderate iron overload."
05/27/2010 - "HCV treatments have some efficacy in HCV infected thalassemics despite partial contraindication to ribavirin and iron overload. "
03/01/2006 - "The mutation of the gen HFE in our patient and the hemolysis caused by ribavirin can be related to the development of the disease, but the iron overload because of ribavirin use is also controversial. "
10/14/2008 - "The association of PCT with chronic viral hepatitis C and the possible role of hepatic iron overload and ribavirin-induced hemolytic anemia in the development of PCT during therapy for chronic viral hepatitis C are discussed."
03/01/2010 - "The aim of this study was to assess occurrence of iron overload in relation to polymorphism of the HFE and the influence of both these factors on efficacy of antiviral treatment with pegylated interferon and ribavirin in patients with CHC. "
|1.||Chelation Therapy (Therapy, Chelation)
01/01/2009 - "The cumulative effects of iron overload cause significant morbidity and mortality if not effectively treated with chelation therapy. "
12/01/2001 - "The decrease in iron overload observed in patients on close follow up implies that compliance with chelation therapy has improved with time and therefore, a favourable influence in survival could be expected."
01/01/1999 - "The procedure is safe and effective in reducing iron overload and can obviate the need for chelation therapy, even when the target Hb S is maintained at the standard 30% range."
04/01/1995 - "The ability to quantitate transfusional iron overload is crucial for determining the need for and the efficacy of chelation therapy in patients with long-standing transfusion-dependent anaemias. "
01/01/1985 - "Chronic transfusion has become practicable since the recent advances in chelation therapy have essentially eliminated the risk of secondary iron overload."
|2.||Blood Transfusion (Blood Transfusions)
06/01/2012 - "Studies evaluating the prevalence of iron overload and its relationship to blood transfusion in pediatric oncology patients are limited. "
10/01/2011 - "In this study, we present an animal model which helps understand the cardiac function changes in patients with secondary iron overload due to repeated blood transfusions. "
12/01/2015 - "Patients with haematopoietic disorders requiring long-term blood transfusions are at risk of iron overload. "
07/01/2015 - "The most serious side effect of regular blood transfusion is iron overload. "
04/01/2015 - "Regular blood transfusions lead to iron overload-related complications. "
|3.||Renal Dialysis (Hemodialysis)
03/01/1990 - "Efficacy of hepatic computed tomography to detect iron overload in chronic hemodialysis."
06/01/2015 - "This study assessed the efficacy, safety, and tolerability of DFX in hemodialysis (HD) patients with iron overload. "
01/01/2014 - "Iron overload used to be considered rare among hemodialysis patients after the advent of erythropoesis-stimulating agents, but recent MRI studies have challenged this view. "
06/01/2008 - "Sixty-one hemodialysis patients, 62 patients with laboratory findings suggestive for iron overload, 57 repeat blood donors were enrolled in the study. "
01/01/2015 - "Iron overload among hemodialysis patients was previously considered rare but is now an increasingly recognized clinical situation. "
|4.||Transplantation (Transplant Recipients)
01/01/2015 - "This finding is supported by the results of NAC or DFX treatment, which reduced ROS level by inhibiting NOX4 and p38MAPK and improved the long-term and multi-lineage engrafment of iron overload HSCs after transplantation. "
09/01/2003 - "Previous studies suggested excess mortality in non-renal transplant recipients with iron overload. "
11/01/1997 - "None of the pre-transplantation MR studies revealed iron overload. "
10/01/2013 - "She is currently 6 years after transplantation with stable, 100% donor engraftment, resolved iron overload, and normal growth and development. "
03/01/2013 - "Both the evolution of iron overload after transplantation and its correlation with late posttransplantation events are unknown. "
04/01/2015 - "Frequent red blood cell transfusion can lead to clinical iron overload and is associated with decreased survival in mds patients. "
01/01/2014 - "Long-term red blood cell transfusion therapy results in iron overload. "
11/01/2012 - "Among infants who received > three erythrocyte transfusions, 50% developed iron overload. "
04/01/2012 - "However, extended exposure to red blood cell transfusions places the patient at an additional risk of iron overload. "
01/01/2012 - "In particular, people with thalassaemia major develop secondary iron overload resulting from regular red blood cell transfusion. "