Stem Cell Factor

A hematopoietic growth factor and the ligand of the cell surface c-kit protein (PROTO-ONCOGENE PROTEINS C-KIT). It is expressed during embryogenesis and is a growth factor for a number of cell types including the MAST CELLS and the MELANOCYTES in addition to the HEMATOPOIETIC STEM CELLS.

Also Known As:

Networked: 1128 relevant articles (22 outcomes, 104 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhao, Li-Ru: 15 articles (11/2020 - 04/2007)
2.	Szmitkowski, Maciej: 11 articles (10/2017 - 05/2003)
3.	Gonzalez-Toledo, Maria E: 8 articles (01/2020 - 04/2009)
4.	Metcalfe, Dean D: 8 articles (01/2018 - 01/2002)
5.	Lukacs, Nicholas W: 7 articles (01/2021 - 02/2003)
6.	Imokawa, Genji: 6 articles (07/2019 - 04/2004)
7.	Mroczko, Barbara: 6 articles (10/2017 - 05/2003)
8.	Piao, Chun-Shu: 6 articles (01/2015 - 04/2007)
9.	Clapp, D Wade: 5 articles (12/2019 - 07/2010)
10.	Yamamoto, T: 5 articles (04/2007 - 11/2000)

Related Diseases

1.	Myocardial Infarction 02/01/2019 - "Mesenchymal stromal cells from rat adipose tissue were transduced with adeno-associated viral (AAV) vector encoding stem cell factor SCF that stimulates proliferation of cardiac c-kit+ cells and improved cardiac function and survival of animals after myocardial infarction. " 12/15/2017 - "Previous studies have shown that stem cell factor (SCF) induces the migration of cardiac stem cells (CSCs) and helps to repair myocardial infarctions. " 01/01/2015 - "Stem cell factor gene transfer improves cardiac function after myocardial infarction in swine." 09/01/2014 - "Cardiac-specific overexpression of human stem cell factor promotes epicardial activation and arteriogenesis after myocardial infarction." 10/09/2013 - "Cardiomyocyte-specific overexpression of human membrane-associated stem cell factor (hSCF) improves cardiac function post-myocardial infarction. "
2.	Stroke (Strokes) 01/01/2015 - "NF-κB is involved in brain repair by stem cell factor and granulocyte-colony stimulating factor in chronic stroke." 04/01/2013 - "The article presents some promising patents on role of stem cell factor and granulocyte-colony stimulating factor in treatment of stroke." 04/01/2013 - "The role of stem cell factor and granulocyte-colony stimulating factor in treatment of stroke." 01/01/2013 - "Reestablishing neuronal networks in the aged brain by stem cell factor and granulocyte-colony stimulating factor in a mouse model of chronic stroke." 12/19/2012 - "The combination of stem cell factor and granulocyte-colony stimulating factor for chronic stroke treatment in aged animals."
3.	Infarction (Infarctions) 12/16/2020 - "Cell Sheet Comprised of Mesenchymal Stromal Cells Overexpressing Stem Cell Factor Promotes Epicardium Activation and Heart Function Improvement in a Rat Model of Myocardium Infarction." 11/01/2005 - "Cell transplantation preserves cardiac function after infarction by infarct stabilization: augmentation by stem cell factor." 11/01/2005 - "Mesenchymal stem cell implantation after myocardial infarction facilitates functional cardiac regeneration without myocyte regeneration through augmentation of endogenous infarct repair, which is enhanced by stem cell factor." 11/09/2012 - "Infarct size, cardiac function, cardiac progenitor cells recruitment, fibrosis, and cardiomyocyte cell-cycle activation were measured at different time points in controls (n=10) and upon stem cell factor gene transfer (n=13) after myocardial infarction. " 11/09/2012 - "We found a regenerative response because of stem cell factor overexpression characterized by an enhancement in cardiac hemodynamic function: an improvement in survival; a reduction in fibrosis, infarct size and apoptosis; an increase in cardiac c-kit(+) progenitor cells recruitment to the injured area; an increase in cardiomyocyte cell-cycle activation; and Wnt/β-catenin pathway induction. "
4.	Ischemia 12/21/2010 - "Stem cell factor expression after renal ischemia promotes tubular epithelial survival." 06/15/2010 - "Stem cell factor (SCF)/c-kit signaling promotes recruitment of endothelial progenitor cells and contributes to ischemia-induced new vessel formation. " 04/24/2009 - "In hindlimb ischemia, perfusion recovery is augmented in lnk(-/-) mice through enhanced proliferation and mobilization of EPCs via c-Kit/stem cell factor. " 12/07/2007 - "We show that HIF-1 directly activates transcription of the gene encoding stem cell factor and that mice lacking the cognate receptor C-KIT have impaired recovery from ischemia. " 01/01/2017 - "We have recently shown that hypoxia and Akt-induced stem cell factor (HASF) protects the heart from ischemia-induced damage and promotes cardiomyocyte proliferation. "
5.	CADASIL 01/01/2018 - "Our previous study has demonstrated that repeated treatment with a combination of stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) reduces VSMC degeneration and cerebral endothelial cell (EC) damage and improves cognitive function in a mouse model of CADASIL (TgNotch3R90C). " 01/01/2020 - "We have demonstrated the efficacy of treatment with combined stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) (SCF+G-CSF) in reducing cerebral small vessel thrombosis in a TgNotch3R90C mouse model of CADASIL. " 01/01/2020 - "Stem Cell Factor in Combination With Granulocyte Colony-Stimulating Factor Protects the Brain From Capillary Thrombosis-Induced Ischemic Neuron Loss in a Mouse Model of CADASIL." 01/01/2018 - "Stem Cell Factor in Combination with Granulocyte Colony-Stimulating Factor reduces Cerebral Capillary Thrombosis in a Mouse Model of CADASIL." 01/01/2014 - "Using both wild type mice and transgenic mice carrying the human mutant Notch3 gene (CADASIL mice), we have recently characterized the pathological features of CADASIL and determined the therapeutic efficacy of two hematopoietic growth factors, stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) in CADASIL. "

Related Drugs and Biologics

1.	Granulocyte Colony-Stimulating Factor (G-CSF)
2.	Stem Cell Factor
3.	Intercellular Signaling Peptides and Proteins (Growth Factors)
4.	Ligands
5.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
6.	Cytokines
7.	Proteins (Proteins, Gene)
8.	Interleukin-3 (Interleukin 3)
9.	Interleukins
10.	Proto-Oncogene Proteins c-kit (Proto-Oncogene Protein c-kit)

Related Therapies and Procedures

1.	Therapeutics
2.	Treatment Delay
3.	Drug Therapy (Chemotherapy)
4.	Hematopoietic Stem Cell Mobilization
5.	Radiotherapy