Cafe-au-Lait Spots (Spot, Cafe-au-Lait)

Light brown pigmented macules associated with NEUROFIBROMATOSIS and Albright's syndrome (see FIBROUS DYSPLASIA, POLYOSTOTIC).

Also Known As:

Spot, Cafe-au-Lait; Cafe au Lait Spots; Cafe-au-Lait Spot; Spots, Cafe-au-Lait

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Skin and Connective Tissue Diseases
- Skin Diseases: 13127
  - Pigmentation Disorders: 149
    - Cafe-au-Lait Spots: 6
Signs and Symptoms Pathological Conditions
- Signs and Symptoms
  - Skin Manifestations: 753
    - Cafe-au-Lait Spots: 6

Related Diseases

1.	Seborrheic Keratosis
2.	Nevus of Ota
3.	Lentigo (Lentiginosis)
4.	Plexiform Neurofibroma
5.	Neurofibromatoses (Neurofibromatosis)

Experts

1.	Cemeli-Cano, Mercedes: 1 article (09/2014)
2.	Fernando-Martínez, Ruth: 1 article (09/2014)
3.	Izquierdo-Álvarez, Silvia: 1 article (09/2014)
4.	López-Pisón, Javier: 1 article (09/2014)
5.	Monge-Galindo, Lorena: 1 article (09/2014)
6.	Peña-Segura, José Luis: 1 article (09/2014)
7.	Fromowitz, Michele: 1 article (01/2014)
8.	Loguinov, Alexandre: 1 article (01/2014)
9.	North, Matthew: 1 article (01/2014)
10.	Shannon, Kevin: 1 article (01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cafe-au-Lait Spots:

1.	Skin Lightening PreparationsIBA 01/05/2014 - "We note that hydroquinone is used cosmetically as a skin-bleaching agent, including by individuals with cafe-au-lait spots (which may be present in individuals with neurofibromatosis who have a mutation in NF1), which could be unadvisable given our findings."
2.	Melanins (Melanin)IBA 07/01/1992 - "Histologically, in the cafe au lait spots, the epidermal basal cells had abundant melanin pigment, but macromelanosomes were not seen throughout the epidermis. "
3.	antineoplaston A10 (A 10)IBA 09/01/2014 - "We present a 10 months child, without a personal interest history, consulting by hypotonic extremities, cafe-au-lait spots and mild psychomotor difficult. "
4.	hydroquinone (Esoterica)FDA Link 01/05/2014 - "We note that hydroquinone is used cosmetically as a skin-bleaching agent, including by individuals with cafe-au-lait spots (which may be present in individuals with neurofibromatosis who have a mutation in NF1), which could be unadvisable given our findings."

Therapies and Procedures

1.	Solid-State Lasers 04/01/2006 - "Q-switched Alexandrite laser is effective in the treatment of nevus of Ota, seborrheic keratosis, tattoo, and naevus fusco-caeruleus zygomaticus, but has limited efficacy for cafe-au-lait-spots, lentigo, naevus of Ito, and spilus naevus."
2.	Tattooing 04/01/2006 - "These PDSs included nevus of Ota, seborrheic keratosis, tattoo, naevus fusco-caeruleus zygomaticus, cafe-au-lait-spots, lentigo, naevus of Ito, and spilus naevus. " 04/01/2006 - "Q-switched Alexandrite laser is effective in the treatment of nevus of Ota, seborrheic keratosis, tattoo, and naevus fusco-caeruleus zygomaticus, but has limited efficacy for cafe-au-lait-spots, lentigo, naevus of Ito, and spilus naevus."
3.	Slit Lamp 11/01/2004 - "Visual acuity and colour tests, visual field examination, slit lamp biomicroscopy of the anterior segment, and a detailed examination of the retina by indirect ophthalmoscopy were performed at diagnosis and follow up in 72 consecutive subjects (29 males, 43 females; aged 1-64 years; mean age 14.6 years) seen at the university departments of paediatrics in Catania and Rome, Italy, during years 1990-2003, who had in restricted body areas: (1) typical pigmentary manifestations of NF1 (cafe au lait spots and freckling) only (n = 48); (2) NF1 pigmentary manifestations and neurofibromas alone (n = 2); (3) neurofibromas only (n = 15); and (4) plexiform neurofibromas only (n = 7). "
4.	Laminectomy 02/01/1999 - "One patient had only cafe-au-lait spots, while the other patient had severe manifestations of NF1 in form of kyphoscoliosis, requiring multiple laminectomies, vertiginous attacks and optic radiation glioma seen on MRI. "