Neuron-Glia Cell Adhesion Molecules (Cell Adhesion Molecules, Neuron Glia)

Cell adhesion molecules that mediate neuron-neuron adhesion and neuron-astrocyte adhesion. They are expressed on neurons and Schwann cells, but not astrocytes and are involved in neuronal migration, neurite fasciculation, and outgrowth. Ng-CAM is immunologically and structurally distinct from NCAM.

Also Known As:

Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ayyavoo, Velpandi: 1 article (04/2018)
2.	Guha, Debjani: 1 article (04/2018)
3.	Wagner, Marc C E: 1 article (04/2018)

Related Diseases

1.	Peripheral Nerve Injuries 09/01/1986 - "In the present study, immunohistological and immunoblot analyses were used to examine the expression of the neural cell adhesion molecule (N-CAM) and the neuron-glia cell adhesion molecule (Ng-CAM) within different parts of a functionally linked neuromuscular system extending from skeletal muscle to the spinal cord after peripheral nerve injury. "
2.	Fasciculation (Fasciculations) 03/22/1993 - "These results suggest that the subcellular distribution of Ng-CAM is regulated differentially, depending on the apposing cell surfaces, and that such differential and developmentally regulated expression may contribute to the elongation, fasciculation, and guidance of spinal axons." 03/22/1993 - "Axons and growth cones that were either fasciculated or in contact with each other strongly expressed Ng-CAM, thus indicating the possible involvement of Ng-CAM in fasciculation of axons and in the contact guidance of growth cones along preexisting axons. " 09/01/1990 - "C-Cells either extend their Ng-CAM-positive axons ventrally without fasciculation to join the Ng-CAM positive ipsilateral longitudinal fascicle at stage 17 (which has already been formed by PL-cell axons), or they cross the midline to join the Ng-CAM positive contralateral longitudinal fascicle after growing through the floor plate at stage 19. " 01/01/1992 - "Anti-Ng-CAM antibodies inhibited migration of granule cells along Bergmann glia in cerebellar explants and fasciculation of neurites in outgrowths from explants of dorsal root ganglia. " 02/01/1986 - "Moreover, antibodies to Ng-CAM inhibited fasciculation of neurites, a functional property shared with NILE. "
3.	Ganglion Cysts (Ganglion) 07/01/1986 - "During culture of dorsal root ganglia in the presence of nerve growth factor, the Ng-CAM/N-CAM ratio rose to 4.95 in neurite outgrowths and 1.99 in the ganglion proper, reflecting both polarity and prevalence modulation. " 11/19/1991 - "Intraretinal pathfinding of ganglion cell axons is perturbed by a monoclonal antibody specific for a G4/Ng-CAM-like cell adhesion molecule." 02/01/1985 - "To identify locations of appearance of Ng-CAM in the peripheral nervous system (PNS), we used a monoclonal antibody called NC-1 that is specific for neural crest cells in early embryos to show the presence of numerous crest cells in the neuritic outgrowth from the neural tube; neither these crest cells nor those in ganglion rudiments bound anti-Ng-CAM antibodies. "
4.	Neuroblastoma 05/01/1998 - "These elements silenced activity of the Ng-CAM promoter in NIH3T3 fibroblasts, but had no effect on its activity in N2A neuroblastoma cells line. " 09/08/1995 - "To identify such factors for Ng-CAM, the neuron-glia CAM, constructs containing portions of the 5' end of the Ng-CAM gene were examined for activity after transfection into N2A neuroblastoma and NIH3T3 cells. "
5.	Pheochromocytoma 02/01/1986 - "The neuron-glia cell adhesion molecule (Ng-CAM) has been identified in mammalian brain tissue and PC12 pheochromocytoma cells as Mr 200,000 and Mr 230,000 species, respectively. "

Related Drugs and Biologics

1.	Neural Cell Adhesion Molecules (Neural Cell Adhesion Molecule)
2.	Antibodies
3.	Monoclonal Antibodies
4.	Contactin 2
5.	Class 5 Receptor-Like Protein Tyrosine Phosphatases
6.	Nerve Growth Factor (NGF)
7.	Cell Adhesion Molecules
8.	Laminin (Merosin)
9.	Fibronectins (Fibronectin)
10.	polysialic acid