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Polymeric Immunoglobulin Receptors (Polymeric Immunoglobulin Receptor)

Specialized Fc receptors (RECEPTORS, FC) for polymeric immunoglobulins, which mediate transcytosis of polymeric IMMUNOGLOBULIN A and IMMUNOGLOBULIN M into external secretions. They are found on the surfaces of epithelial cells and hepatocytes. After binding to IMMUNOGLOBULIN A, the receptor-ligand complex undergoes endocytosis, transport by vesicle, and secretion into the lumen by exocytosis. Before release, the part of the receptor (SECRETORY COMPONENT) that is bound to IMMUNOGLOBULIN A is proteolytically cleaved from its transmembrane tail. (From Rosen et al., The Dictionary of Immunology, 1989)
Also Known As:
Polymeric Immunoglobulin Receptor; Receptors, Polymeric Immunoglobulin; Poly-Ig Receptor; Polyimmunoglobulin Receptor; Polymeric Ig Receptor; Receptor, Polyimmunoglobulin; Receptor, Polymeric Ig; Ig Receptor, Polymeric; Immunoglobulin Receptor, Polymeric; Immunoglobulin Receptors, Polymeric; Poly Ig Receptor; Receptor, Poly-Ig; Receptor, Polymeric Immunoglobulin
Networked: 71 relevant articles (3 outcomes, 7 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Strugnell, Richard A: 3 articles (01/2015 - 01/2005)
2. Wijburg, Odilia L C: 3 articles (01/2015 - 01/2005)
3. Pilette, Charles: 3 articles (09/2014 - 04/2003)
4. Uhlén, Mathias: 3 articles (01/2014 - 01/2014)
5. Jirström, Karin: 3 articles (01/2014 - 01/2014)
6. Nodin, Björn: 3 articles (01/2014 - 01/2014)
7. Gaber, Alexander: 3 articles (01/2014 - 01/2014)
8. Nanno, Masanobu: 3 articles (05/2010 - 03/2002)
9. Eberhard, Jakob: 2 articles (01/2014 - 01/2014)
10. Fristedt, Richard: 2 articles (01/2014 - 01/2014)

Related Diseases

1. Infection
2. Bacterial Infections (Bacterial Infection)
3. Diarrhea
4. Epstein-Barr Virus Infections
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Secretory Immunoglobulin A (SIgA)
2. Antibodies
3. Combined Vaccines
4. Nasopharyngeal carcinoma
5. Immunoglobulin A (IgA)
6. Leukocyte Elastase (Neutrophil Elastase)
7. Biological Markers (Surrogate Marker)
8. Salivary Proteins and Peptides
9. Prolactin
10. Complementary DNA (cDNA)