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Polymeric Immunoglobulin Receptors (Polymeric Immunoglobulin Receptor)

Specialized Fc receptors (RECEPTORS, FC) for polymeric immunoglobulins, which mediate transcytosis of polymeric IMMUNOGLOBULIN A and IMMUNOGLOBULIN M into external secretions. They are found on the surfaces of epithelial cells and hepatocytes. After binding to IMMUNOGLOBULIN A, the receptor-ligand complex undergoes endocytosis, transport by vesicle, and secretion into the lumen by exocytosis. Before release, the part of the receptor (SECRETORY COMPONENT) that is bound to IMMUNOGLOBULIN A is proteolytically cleaved from its transmembrane tail. (From Rosen et al., The Dictionary of Immunology, 1989)
Also Known As:
Polymeric Immunoglobulin Receptor; Receptors, Polymeric Immunoglobulin; Poly-Ig Receptor; Polyimmunoglobulin Receptor; Polymeric Ig Receptor; Receptor, Polyimmunoglobulin; Receptor, Polymeric Ig; Ig Receptor, Polymeric; Immunoglobulin Receptor, Polymeric; Immunoglobulin Receptors, Polymeric; Poly Ig Receptor; Receptor, Poly-Ig; Receptor, Polymeric Immunoglobulin
Networked: 130 relevant articles (3 outcomes, 10 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Blackwell, Timothy S: 5 articles (01/2022 - 08/2011)
2. Richmond, Bradley W: 4 articles (01/2022 - 04/2016)
3. Polosukhin, Vasiliy V: 4 articles (11/2018 - 08/2011)
4. Pilette, Charles: 4 articles (01/2018 - 04/2003)
5. Du, Rui-Hong: 3 articles (01/2022 - 04/2016)
6. Bhattacharya, Satyajit: 3 articles (01/2018 - 05/2013)
7. Strugnell, Richard A: 3 articles (01/2015 - 01/2005)
8. Wijburg, Odilia L C: 3 articles (01/2015 - 01/2005)
9. Gaber, Alexander: 3 articles (04/2014 - 01/2014)
10. Jirström, Karin: 3 articles (04/2014 - 01/2014)

Related Diseases

1. Infections
2. Bacterial Infections (Bacterial Infection)
3. Diarrhea
4. Nasopharyngeal Carcinoma
5. Epstein-Barr Virus Infections

Related Drugs and Biologics

1. Secretory Immunoglobulin A (SIgA)
2. Vaccines
3. Antibodies
4. Combined Vaccines
5. Proteins (Proteins, Gene)
6. Biomarkers (Surrogate Marker)
7. Immunoglobulin A (IgA)
8. Leukocyte Elastase (Neutrophil Elastase)
9. Salivary Proteins and Peptides
10. Prolactin