HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Prostatic Intraepithelial Neoplasia

A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
Also Known As:
Intraepithelial Prostatic Neoplasia; Prostatic Intraepithelial Neoplasms; Intraepithelial Neoplasia, Prostatic; Intraepithelial Neoplasm, Prostatic; Intraepithelial Neoplasms, Prostatic; Intraepithelial Prostatic Neoplasias; Neoplasia, Intraepithelial Prostatic; Neoplasm, Prostatic Intraepithelial; Neoplasms, Prostatic Intraepithelial; Prostatic Intraepithelial Neoplasias; Prostatic Intraepithelial Neoplasm; Prostatic Neoplasia, Intraepithelial; Neoplasia, Prostatic Intraepithelial
Networked: 779 relevant articles (13 outcomes, 105 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Prostatic Neoplasms (Prostate Cancer)
3. Adenocarcinoma
4. Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
5. Carcinoma (Carcinomatosis)

Experts

1. Montironi, Rodolfo: 24 articles (01/2021 - 06/2002)
2. Cheng, Liang: 21 articles (01/2016 - 02/2002)
3. Mazzucchelli, Roberta: 14 articles (02/2013 - 06/2002)
4. Epstein, Jonathan I: 11 articles (01/2021 - 09/2002)
5. Scarpelli, Marina: 11 articles (02/2013 - 06/2002)
6. Rubin, Mark A: 10 articles (10/2022 - 04/2002)
7. Lopez-Beltran, Antonio: 10 articles (02/2013 - 04/2007)
8. Bostwick, David G: 10 articles (10/2009 - 01/2003)
9. De Marzo, Angelo M: 9 articles (01/2018 - 09/2003)
10. Santinelli, Alfredo: 9 articles (02/2013 - 06/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Prostatic Intraepithelial Neoplasia:
1. AndrogensIBA
2. Finasteride (Propecia)FDA LinkGeneric
3. Toremifene (Fareston)FDA Link
4. Prostate-Specific Antigen (Semenogelase)IBA
5. SeleniumIBA
6. Vitamin EFDA LinkGeneric
7. Androgen Receptors (Androgen Receptor)IBA
8. DNA (Deoxyribonucleic Acid)IBA
9. TensinsIBA
01/01/2019 - "We report that Pten (phosphatase and tensin homologue) ablation in prostatic epithelial cells of adult mice promotes cell proliferation to generate prostatic intraepithelial neoplasia. "
07/20/2015 - "The phosphatase and tensin homolog (PTEN) and the zinc finger homeobox 3 (ZFHX3)/AT-motif binding factor 1 (ATBF1) genes have been established as tumor suppressor genes in prostate cancer by their frequent deletions and mutations in human prostate cancer and by the formation of mouse prostatic intraepithelial neoplasia (mPIN) or tumor by their deletions in mouse prostates. "
01/01/2016 - "Seventy-eight radical prostatectomies were used to construct 3 tissue microarrays consisting of 512 cores, including benign tissue, benign prostatic hyperplasia, high-grade prostatic intraepithelial neoplasia (HGPIN), and adenocarcinoma, Gleason patterns 3 to 5. Immunohistochemistry for phosphatase and tensin homologue (PTEN) and double-stain MAGI-2/p63 was performed and analyzed by visual and image analysis, the latter as percent of analyzed area (%AREA), and mean optical density multiplied by %AREA (STAIN). "
01/01/2020 - "The prostate-specific phosphatase and tensin homolog deleted on chromosome 10 (Pten) gene-conditional knockout (KO) mouse carcinogenesis model is highly desirable for studies of prostate cancer biology and chemoprevention due to its close resemblance of primary molecular defect and many histopathological features of human prostate cancer including androgen response and disease progression from prostatic intraepithelial neoplasia to invasive adenocarcinoma. "
01/01/2016 - "Given that human prostate cancer arises from precancerous lesions such as high-grade prostatic intraepithelial neoplasia (HG-PIN), which frequently have lost phosphatase and tensin homolog (PTEN) tumor suppressor permitting phosphatidylinositol-3-OH kinase (PI3K)-protein kinase B (AKT) oncogenic signaling, we tested the efficacy of MSeA to inhibit HG-PIN progression in Pten prostate-specific knockout (KO) mice and assessed the mechanistic involvement of p53-mediated cellular senescence and of the androgen receptor (AR). "
10. Phosphoric Monoester Hydrolases (Phosphatases)IBA
07/20/2015 - "The phosphatase and tensin homolog (PTEN) and the zinc finger homeobox 3 (ZFHX3)/AT-motif binding factor 1 (ATBF1) genes have been established as tumor suppressor genes in prostate cancer by their frequent deletions and mutations in human prostate cancer and by the formation of mouse prostatic intraepithelial neoplasia (mPIN) or tumor by their deletions in mouse prostates. "
01/01/2016 - "Seventy-eight radical prostatectomies were used to construct 3 tissue microarrays consisting of 512 cores, including benign tissue, benign prostatic hyperplasia, high-grade prostatic intraepithelial neoplasia (HGPIN), and adenocarcinoma, Gleason patterns 3 to 5. Immunohistochemistry for phosphatase and tensin homologue (PTEN) and double-stain MAGI-2/p63 was performed and analyzed by visual and image analysis, the latter as percent of analyzed area (%AREA), and mean optical density multiplied by %AREA (STAIN). "
01/01/2020 - "The prostate-specific phosphatase and tensin homolog deleted on chromosome 10 (Pten) gene-conditional knockout (KO) mouse carcinogenesis model is highly desirable for studies of prostate cancer biology and chemoprevention due to its close resemblance of primary molecular defect and many histopathological features of human prostate cancer including androgen response and disease progression from prostatic intraepithelial neoplasia to invasive adenocarcinoma. "
01/01/2016 - "Given that human prostate cancer arises from precancerous lesions such as high-grade prostatic intraepithelial neoplasia (HG-PIN), which frequently have lost phosphatase and tensin homolog (PTEN) tumor suppressor permitting phosphatidylinositol-3-OH kinase (PI3K)-protein kinase B (AKT) oncogenic signaling, we tested the efficacy of MSeA to inhibit HG-PIN progression in Pten prostate-specific knockout (KO) mice and assessed the mechanistic involvement of p53-mediated cellular senescence and of the androgen receptor (AR). "

Therapies and Procedures

1. Therapeutics
2. Prostatectomy (Retropubic Prostatectomy)
3. Chemoprevention
4. Castration
5. Radiotherapy