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Platelet Glycoprotein GPIIb-IIIa Complex

Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
Also Known As:
Glycoproteins IIb-IIIa; Integrin alpha-IIb beta-3; GPIIb IIIa Receptors; Glycoproteins IIb IIIa; Integrin alpha IIb beta 3; Platelet Glycoprotein GPIIb IIIa Complex; Receptors, GPIIb-IIIa; alphaIIbbeta3, Integrin; beta-3, Integrin alpha-IIb; GPIIb-IIIa Receptors; Integrin alphaIIbbeta3
Networked: 175 relevant articles (4 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Nurden, Alan T: 5 articles (02/2008 - 03/2002)
2. Shattil, Sanford J: 4 articles (09/2008 - 09/2004)
3. Nurden, Paquita: 4 articles (02/2008 - 03/2002)
4. Jackson, Shaun P: 4 articles (09/2007 - 01/2002)
5. Combrié, Robert: 4 articles (02/2004 - 03/2002)
6. Kasirer-Friede, Ana: 3 articles (09/2008 - 08/2005)
7. Salem, Hatem H: 3 articles (09/2007 - 01/2002)
8. Nieswandt, Bernhard: 3 articles (07/2006 - 06/2002)
9. Schulte, Valerie: 3 articles (07/2006 - 06/2002)
10. Coller, Barry S: 3 articles (04/2006 - 02/2003)

Related Diseases

1. Thrombosis (Thrombus)
2. Thrombasthenia (Glanzmann Thrombasthenia)
3. Unstable Angina
4. Thrombocytopenia (Thrombopenia)
5. Myocardial Infarction

Related Drugs and Biologics

1. Glycoproteins (Glycoprotein)
2. Thrombin
3. Heparin (Liquaemin)
4. Immunoglobulin G (IgG)
5. Calcium
6. Phosphatidylinositol 3-Kinases
7. Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)
8. Fibrinogen (Factor I)
9. Integrin alphaVbeta3
10. Autoantibodies

Related Therapies and Procedures

1. Angioplasty (Angioplasty, Transluminal)