CD40 Antigens

Members of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. They are found on mature B-LYMPHOCYTES, some EPITHELIAL CELLS; and lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations in the CD40 antigen gene result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

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Networked: 32 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Antonacopoulou, Anna G: 1 article (01/2021)
2.	Dimitrakopoulos, Foteinos-Ioannis D: 1 article (01/2021)
3.	Dougenis, Dimitrios: 1 article (01/2021)
4.	Kalofonos, Haralabos P: 1 article (01/2021)
5.	Kalofonou, Melpomeni: 1 article (01/2021)
6.	Kottorou, Anastasia E: 1 article (01/2021)
7.	Koutras, Angelos: 1 article (01/2021)
8.	Makatsoris, Thomas: 1 article (01/2021)
9.	Panagopoulos, Nikolaos: 1 article (01/2021)
10.	Tzelepi, Vasiliki: 1 article (01/2021)

Related Diseases

1.	Non-Hodgkin Lymphoma (Lymphosarcoma) 12/15/1990 - "Temporal association of CD40 antigen expression with discrete stages of human B-cell ontogeny and the efficacy of anti-CD40 immunotoxins against clonogenic B-lineage acute lymphoblastic leukemia as well as B-lineage non-Hodgkin's lymphoma cells." 07/01/1996 - "Data on the expression of the CD40 antigen on various B cell malignancies (acute and chronic leukemias, non-Hodgkin's lymphoma and multiple myeloma) are presented. "
2.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 12/15/1990 - "Temporal association of CD40 antigen expression with discrete stages of human B-cell ontogeny and the efficacy of anti-CD40 immunotoxins against clonogenic B-lineage acute lymphoblastic leukemia as well as B-lineage non-Hodgkin's lymphoma cells."
3.	Epstein-Barr Virus Infections 04/01/1995 - "The study included 11 cases of Hodgkin's disease in which latent Epstein-Barr virus (EBV) infection could be demonstrated within tumour cells by in situ hybridisation for the EBV encoded early RNAs (EBERs).Results-In all cases, irrespective of EBV status, Reed-Sternberg cells and their variants (HRS cells) showed strong expression of both B7 and CD40 antigens. " 02/01/1993 - "Accordingly, whereas polyclonal activation via triggering of surface immunoglobulins or CD40 antigen induced highly purified normal human B lymphocytes to produce only low (0.3-0.4 ng/ml) but significant amounts of hIL-10, EBV infection induced them to secrete high amounts of hIL-10 (4-9 ng/ml). " 01/01/1993 - "Epstein-Barr virus infection, hydrocortisone, and MAb to the B-cell antigen CD40. " 04/01/1995 - "Expression of B7 (CD80) and CD40 antigens and the CD40 ligand in Hodgkin's disease is independent of latent Epstein-Barr virus infection."
4.	Hodgkin Disease (Hodgkin's Disease) 02/01/1995 - "Expression of functional CD40 antigen on Reed-Sternberg cells and Hodgkin's disease cell lines." 04/01/1995 - "The study included 11 cases of Hodgkin's disease in which latent Epstein-Barr virus (EBV) infection could be demonstrated within tumour cells by in situ hybridisation for the EBV encoded early RNAs (EBERs).Results-In all cases, irrespective of EBV status, Reed-Sternberg cells and their variants (HRS cells) showed strong expression of both B7 and CD40 antigens. " 04/01/1995 - "Expression of B7 (CD80) and CD40 antigens and the CD40 ligand in Hodgkin's disease is independent of latent Epstein-Barr virus infection." 06/01/1996 - "Recent data have shown that CD40 antigen and its ligand (CD40L), and the CD26 molecule are differentially expressed among Hodgkin's disease (HD) (CD40+, CD26, CD40L), peripheral T-cell (PTCL) (CD40L+/-, CD40, CD26) and CD30 positive anaplastic large cell (ALC) (CD26+, CD40L) lymphomas. "
5.	Neoplasms (Cancer) 11/01/1996 - "Recently we found that many different mature B-cell malignancies proliferate upon stimulation via the CD40 antigen, and this led us to investigate whether a similar CD40 activation on ALL cells could also induce proliferation. " 05/01/1996 - "CD40 antigen is expressed by endothelial cells and tumor cells in Kaposi's sarcoma." 07/01/1996 - "In this review, an overview of the CD40 antigen and the CD40 ligand is given, focussing on their possible role in B cell malignancies. " 05/01/1996 - "Western blot analysis of tumor lysates detected a 48- to 50-kd glycoprotein corresponding to the CD40 antigen expressed by B lymphocytes. " 01/01/1997 - "Our results indicate a-down-regulation or a drastic loss of CD40 antigen by tumor cells from basal cell carcinoma and squamous cell carcinoma and a moderate to discrete CD40 reactivity of keratinocyte from proliferative layers of benign viral-induced lesions. "

Related Drugs and Biologics

1.	Immunotoxins (Immunotoxin)
2.	CD40 Ligand (CD40L)
3.	Antigens
4.	Ligands
5.	Messenger RNA (mRNA)
6.	B-Cell Antigen Receptors (B Cell Antigen Receptors)
7.	B-Cell Activation Factor Receptor
8.	Lymphotoxin beta Receptor
9.	Nevirapine (Viramune)
10.	Cancer Vaccines