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CD40 Antigens

A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Also Known As:
Antigens, CD40; CD40 Antigen; CDw40 Antigen; TNFRSF5 Receptor; Antigen, CD40; Antigen, CDw40; Receptor, TNFRSF5; Tumor Necrosis Factor Receptor Superfamily, Member 5
Networked: 29 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Bonehill, Aude: 1 article (01/2010)
2. Thielemans, Kris: 1 article (01/2010)
3. Van Nuffel, An M T: 1 article (01/2010)
4. Heirman, Carlo: 1 article (01/2010)
5. Corthals, Jurgen: 1 article (01/2010)
6. Neyns, Bart: 1 article (01/2010)
7. Hernandez-Ilizaliturri, Francisco J: 1 article (06/2009)
8. Czuczman, Myron S: 1 article (06/2009)
9. Khubchandani, Sapna: 1 article (06/2009)
10. Barone, Carlo: 1 article (06/2008)

Related Diseases

1. Non-Hodgkin Lymphoma (Lymphosarcoma)
2. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
3. Hodgkin Disease (Hodgkin's Disease)
4. Epstein-Barr Virus Infections
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Immunotoxins (Immunotoxin)
2. Antigens
3. CD40 Ligand (CD40L)
4. Messenger RNA (mRNA)
5. Nevirapine (Viramune)
6. CD19 Antigens
7. Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
8. Oligodeoxyribonucleotides
9. Immunoglobulin M (IgM)
10. Hydrocortisone (Cortisol)