Integrin beta1

Integrin beta chain expressed as a heterodimer that is non-covalently associated with specific alpha-chains of the CD49 family (CD49a-f). It is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)

Also Known As:

4B4 Antigen; CD29 Antigen; CDw29 Antigen; beta1 Integrin; Antigen, 4B4; Antigen, CD29; Antigen, CDw29; Integrin, beta1; Antigens, CD29; CD29 Antigens

Networked: 368 relevant articles (7 outcomes, 43 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Integrins: 14304
        Integrin beta Chains: 15
        Integrin beta1: 368
        pactolus: 1
        human Itgb1 protein
        human ITGBL1 protein
        integrin beta1C
        mouse Itgb1 protein

Experts

1.	Bissell, Mina J: 6 articles (11/2013 - 10/2002)
2.	Park, Catherine C: 4 articles (07/2010 - 02/2006)
3.	Watt, Fiona M: 4 articles (02/2009 - 09/2004)
4.	Blaheta, Roman A: 4 articles (09/2008 - 01/2005)
5.	Jonas, Dietger: 4 articles (09/2008 - 01/2005)
6.	Ross, Robert S: 4 articles (05/2008 - 03/2002)
7.	Zha, Xiliang: 4 articles (10/2007 - 01/2004)
8.	Marra, Ersilia: 4 articles (08/2006 - 12/2003)
9.	Moro, Loredana: 4 articles (08/2006 - 12/2003)
10.	Qin, Jian: 4 articles (01/2005 - 10/2003)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2016 - "In this study, we combined Taiwanese microarray data from the GEO database and The Cancer Genome Atlas (TCGA) database to study the role of Integrin Beta1 (ITGB1) in TNBC. " 09/29/1998 - "Our study with a panel of cancer cell lines further showed a close correlation between alpha2 beta1 and alpha3 beta1 integrin receptor expression and the capability to attach to cortical bone. " 06/01/2022 - "LAPTM4B-35 promotes cancer cell migration via stimulating integrin beta1 recycling and focal adhesion dynamics." 01/01/2015 - "Based on the knowledge mentioned above, we present hypotheses that we can inhibit specifically the expression of alpha5/beta1 integrin in cancer cells with the help of complementary replication defective adenovirus. " 07/28/2011 - "5'-NIO inhibited the beta1 Integrin/FAK/Akt pathway which can then facilitate invasion and/or migration of cancer cells through the extracellular matrix (ECM). "
2.	Infections 03/01/2010 - "In the absence of beta1 integrin, endogenous Ag-specific CD4 T cells uniformly express high levels of alpha4beta7 after Listeria monocytogenes infection. " 01/01/2008 - "pseudotuberculosis infection activated Rho by a mechanism that was dependent on YopB and on high affinity bacteria interaction with beta1 integrin receptors. " 01/01/2002 - "A large proportion of neonatal Peyer's patch lymphocytes in wild-type mice were beta7 and beta1 integrin low and both populations increased in response to MMTV infection. " 04/01/1997 - "pseudotuberculosis infection was specifically related to exposure of beta1 integrin (normally concealed by tight junctions) to the apical compartment, as Y. " 11/01/2001 - "The fact that the beta1 integrin-activating antibody TS2/16 can enhance alpha(v)beta1-mediated Ad5 infection suggests that the efficacy of Ad5-mediated gene transfer might be influenced not only by the level of cell surface expression of integrins but also by their state of activation."
3.	Carcinoma (Carcinomatosis) 06/01/2008 - "We recently showed that the motility of the malignant Calu-1 human epidermoid lung carcinoma cells correlates to their expression levels of alpha2, alpha3, alpha6, and beta1 integrin subunits. " 08/03/2007 - "Effect of KAI1/CD82 on the beta1 integrin maturation in highly migratory carcinoma cells." 07/01/2007 - "Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes." 04/01/2005 - "Down-regulation of CD9 in human ovarian carcinoma cell might contribute to peritoneal dissemination: morphologic alteration and reduced expression of beta1 integrin subsets." 01/11/2005 - "We therefore investigated the adhesion capacity of colon, pancreas, prostate and kidney carcinoma cell lines to endothelium, as well as their beta1 integrin expression profile before and after MMF treatment. "
4.	Hemangioma (Angioma) 11/01/2008 - "Normalization of the constitutive VEGFR2 signaling in hemECs with soluble VEGFR1 or antibodies that neutralize VEGF or stimulate beta1 integrin suggests that local administration of these or similar agents may be effective in hemangioma treatment."
5.	Head and Neck Neoplasms (Head and Neck Cancer) 01/01/2016 - "Efficacy of Beta1 Integrin and EGFR Targeting in Sphere-Forming Human Head and Neck Cancer Cells."

Related Drugs and Biologics

1.	Fibronectins (Fibronectin)
2.	Integrins
3.	Cadherins (E-Cadherin)
4.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
5.	Integrin beta3 (GPIIIa)
6.	Imatinib Mesylate (Gleevec)
7.	Antibodies
8.	Protein Isoforms (Isoforms)
9.	Integrin alpha3
10.	Progesterone

Related Therapies and Procedures

1.	Radiotherapy
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)
4.	Tooth Movement Techniques
5.	Ligation