Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)

Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)

Also Known As:

Networked: 3666 relevant articles (92 outcomes, 440 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mohan, Chandra: 9 articles (01/2022 - 03/2007)
2.	Sibson, Nicola R: 9 articles (01/2022 - 10/2007)
3.	Schalkwijk, Casper G: 9 articles (08/2015 - 06/2005)
4.	Libby, Peter: 9 articles (04/2015 - 09/2002)
5.	Stehouwer, Coen D A: 9 articles (03/2015 - 04/2002)
6.	Tang, Chih-Hsin: 8 articles (06/2022 - 05/2013)
7.	Yang, Chuen-Mao: 8 articles (08/2015 - 10/2007)
8.	Choudhury, Robin P: 8 articles (05/2013 - 10/2007)
9.	Panés, Julián: 8 articles (03/2006 - 04/2002)
10.	Liu, Ju-Fang: 7 articles (10/2021 - 05/2013)

Related Diseases

1.	Inflammation (Inflammations) 04/30/2023 - "By inhibiting VCAM-1 expression through the miR-126 mediated pathway, vascular endothelial inflammation can be efficiently relieved. " 08/22/2023 - "Our studies indicate that TRIM65 attenuates the endothelial inflammatory response by targeting VCAM-1 for ubiquitination and provides a potential therapeutic target for the inhibition of endothelial inflammation in AS." 12/01/2021 - "Our study demonstrated that silencing VCAM-1 in BMSCs could inhibit inflammation and apoptosis, thus improving cardiac function in MI." 01/01/2020 - "Taken together, our studies suggest that TRIM65-mediated degradation of VCAM-1 represents a potential mechanism that controls the duration and magnitude of inflammation." 06/01/2009 - "To study the expression and significance of vascular cell adhesion molecule-1 (VCAM-1) in subjects with allergic inflammation of respiratory tract. "
2.	Atherosclerosis 02/01/2000 - "In a second study, VCAM-1 expression in the aortic arch and the extent of atherosclerosis in the aortic origin were significantly greater in old LDLR-/- mice than in young LDLR-/- mice. " 11/17/2020 - "Methods and Results In MESA (the Multi-Ethnic Study of Atherosclerosis), we evaluated the association of VCAM-1 at examination 2 (2002-2004) with incident HF (HFpEF and HF with reduced ejection fraction) after adjustment for cardiovascular risk factors. " 05/14/2015 - "This study demonstrates, in vitro, the regulatory mechanisms involved in MCP-1 production in three cellular models and VCAM-1 production in HUVECs, and thus mimics the endothelial dysfunction caused by AGEs in early atherosclerosis. " 10/24/2023 - "Vascular cell adhesion molecule-1 (VCAM-1) has been well established as a critical contributor to atherosclerosis and consequently as an attractive therapeutic target for anti-atherosclerotic drug candidates. " 08/22/2023 - "Endothelial cell activation, characterized by increased levels of vascular cell adhesion molecule 1 (VCAM-1), plays a crucial role in the development of atherosclerosis (AS). "
3.	Neoplasms (Cancer) 08/05/2023 - "These data were correlated with the variable expression of α and β Na+/K+ pump subunits in tumor cells, resulting in decreased ability to adhere to the VCAM-1 substrate in functional flow chamber studies. " 10/28/2020 - "This study highlights the critical role of TAMs via CCL5 and VCAM-1 pathways in E-cig promoted BC tumor development." 03/01/2020 - "miR-26a mimic and miR-26a inhibitor were transfected to study the effect on progression and migration of tumor cell as well as on levels of VCAM-1. " 12/01/2018 - "Several studies have shown that vascular cell adhesion molecule-1 increases invasion in tumor cells. " 05/03/2018 - "Previous studies showed that MCPIP3 inhibits the expression of proinflammatory genes, such as vascular cell adhesion molecule (VCAM)-1, in human endothelial cells, but the roles and functions of MCPIP3 in cancer cells are still unknown. "
4.	Necrosis 03/01/2013 - "They were effective in attenuation of inflammatory nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signalling: decrease of tumour necrosis factor-alpha (TNF-α)-induced leukocytes adhesion, expression of adhesion molecules inter-cellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), and nuclear translocation of NF-κB components as well as some revert of inhibitor of kappa B (IκB) ubiquitination. " 06/01/2021 - "VCAM-1 level also correlated with leukocyte infiltration and fibrinoid necrosis/karyorrhexis scores in active LN kidney biopsies. " 12/01/2014 - "As compared to controls, GD-HUVEC exhibited enhanced monocyte adhesion and vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1(ICAM-1) expression and exposure on plasma membrane after tumour necrosis factor-alpha(TNF-α) stimulation (Western blot, flow cytometer). " 01/01/2012 - "By day 6, the monocyte-derived cells expressed vascular cell adhesion molecule 1 in response to tumour necrosis factor alpha. " 11/01/2008 - "After treatment with PUVA, there was a fall in circulating levels of vascular cell adhesion molecule in 10/13 patients (P = 0.059) and a significant increase in tumour necrosis factor-alpha in 9 of 13 patients (P = 0.036). "
5.	Breast Neoplasms (Breast Cancer) 01/01/2016 - "Then, the anti-metastatic efficacy of PHN is measured in metastatic 4T1 breast cancer cells, which effectively confirms the superior inhibitory effects on cell migration and invasion activities, VCAM-1 expression and cell-cell binding of RAW 264.7 to 4T1 cells. " 11/15/2019 - "Transcriptional profiling of breast cancer-associated lymphatic vessels reveals VCAM-1 as regulator of lymphatic invasion and permeability." 07/23/2019 - "Recent progress in breast cancer research has led to the identification of Vascular Cell Adhesion Molecule-1 (VCAM-1) as a key actor of metastatic colonization. " 02/27/2014 - "Our findings uncover the possible mechanism of VCAM-1 activation facilitating breast cancer progression, and suggest that targeting VCAM-1 is an attractive strategy for therapeutic intervention. " 02/27/2014 - "Activation of VCAM-1 and its associated molecule CD44 leads to increased malignant potential of breast cancer cells."

Related Drugs and Biologics

1.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
2.	Interleukin-6 (Interleukin 6)
3.	E-Selectin
4.	Lipids
5.	C-Reactive Protein
6.	Apolipoproteins E (ApoE)
7.	Caspase 3 (Caspase-3)
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10.	NF-kappa B (NF-kB)

Related Therapies and Procedures

1.	Microbubbles
2.	Ligation
3.	Glycemic Control
4.	Hematopoietic Stem Cell Transplantation
5.	Injections