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Proto-Oncogene Proteins c-kit (Proto-Oncogene Protein c-kit)

A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
Also Known As:
Proto-Oncogene Protein c-kit; CD117 Antigen; Proto-Oncogene Protein kit; SCF Receptor; p145 c-kit; p145c-kit; Proto Oncogene Protein c kit; Proto Oncogene Protein kit; Proto Oncogene Proteins c kit; Proto-Oncogene Protein, kit; c kit Protein; c kit Receptor; c-kit, Proto-Oncogene Protein; c-kit, Proto-Oncogene Proteins; c-kit, p145; kit Proto Oncogene Protein; p145 c kit; p145c kit; Antigens, CD117; CD117 Antigens; Receptor, Stem Cell Factor; Stem Cell Factor Receptor; c-kit Protein; c-kit Receptor; kit Proto-Oncogene Protein; p145(c-kit)
Networked: 471 relevant articles (4 outcomes, 48 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Ranieri, Girolamo: 5 articles (01/2018 - 01/2013)
2. Ammendola, Michele: 4 articles (01/2018 - 01/2013)
3. Patruno, Rosa: 4 articles (01/2018 - 01/2013)
4. Brading, Alison F: 4 articles (03/2014 - 09/2004)
5. Hermine, O: 4 articles (03/2011 - 09/2003)
6. Gadaleta, Cosmo Damiano: 3 articles (01/2018 - 07/2014)
7. Luposella, Maria: 3 articles (01/2018 - 01/2013)
8. Marech, Ilaria: 3 articles (01/2018 - 11/2013)
9. Sacco, Rosario: 3 articles (01/2018 - 01/2013)
10. Zizzo, Nicola: 3 articles (01/2018 - 07/2014)

Related Diseases

1. Cicatrix (Scar)
2. Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
3. Inflammation (Inflammations)
4. Acute Cholecystitis
5. Renal Cell Carcinoma (Grawitz Tumor)

Related Drugs and Biologics

1. Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)
2. Phosphotransferases (Kinase)
3. Stem Cell Factor
4. Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
5. Tyrosine Kinase Inhibitors
6. Sunitinib (Sutent)
7. tyrosine receptor (receptor, tyrosine)
8. Platelet-Derived Growth Factor
9. Chymases (Chymase)
10. Messenger RNA (mRNA)

Related Therapies and Procedures

1. Therapeutics
2. Orchiectomy (Orchidectomy)
3. Drug Therapy (Chemotherapy)
4. Molecular Targeted Therapy
5. Bone Marrow Transplantation (Transplantation, Bone Marrow)