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Proto-Oncogene Proteins c-kit (Proto-Oncogene Protein c-kit)

A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
Also Known As:
Proto-Oncogene Protein c-kit; CD117 Antigen; Proto-Oncogene Protein kit; SCF Receptor; p145 c-kit; p145c-kit; Proto Oncogene Protein c kit; Proto Oncogene Protein kit; Proto Oncogene Proteins c kit; Proto-Oncogene Protein, kit; c kit Protein; c kit Receptor; c-kit, Proto-Oncogene Protein; c-kit, Proto-Oncogene Proteins; c-kit, p145; kit Proto Oncogene Protein; p145 c kit; p145c kit; Antigens, CD117; CD117 Antigens; Receptor, Stem Cell Factor; Stem Cell Factor Receptor; c-kit Protein; c-kit Receptor; kit Proto-Oncogene Protein; p145(c-kit)
Networked: 382 relevant articles (3 outcomes, 40 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Hermine, O: 4 articles (03/2011 - 09/2003)
2. Imokawa, Genji: 3 articles (07/2013 - 04/2004)
3. Gottschling, Sandra: 3 articles (03/2013 - 12/2011)
4. Thomas, Michael: 3 articles (03/2013 - 12/2011)
5. Schnabel, Philipp A: 3 articles (03/2013 - 12/2011)
6. Herpel, Esther: 3 articles (03/2013 - 12/2011)
7. Jensen, Katrin: 3 articles (03/2013 - 12/2011)
8. Herth, Felix J F: 3 articles (03/2013 - 12/2011)
9. Weisel, Richard D: 3 articles (09/2007 - 07/2006)
10. Li, Ren-Ke: 3 articles (09/2007 - 07/2006)

Related Diseases

1. Cicatrix (Scar)
2. Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
3. Renal Cell Carcinoma (Grawitz Tumor)
4. Urinary Bladder Neoplasms (Bladder Cancer)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Protein-Tyrosine Kinases (Tyrosine Kinase)
2. Phosphotransferases (Kinase)
3. Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)
4. Stem Cell Factor
5. tyrosine receptor (receptor, tyrosine)
6. Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
7. sunitinib (Sutent)
8. Chymases (Chymase)
9. Platelet-Derived Growth Factor
10. imatinib (Gleevec)

Related Therapies and Procedures

1. Orchiectomy (Orchidectomy)
2. Drug Therapy (Chemotherapy)
3. Bone Marrow Transplantation (Transplantation, Bone Marrow)
4. Heterologous Transplantation (Xenotransplantation)
5. Enterostomy