|1.||Lip, Gregory Y H: 32 articles (08/2014 - 05/2002)|
|2.||Blann, Andrew D: 24 articles (08/2015 - 05/2002)|
|3.||Blann, A D: 24 articles (01/2014 - 01/2000)|
|4.||Wakefield, Thomas W: 19 articles (04/2015 - 09/2002)|
|5.||Myers, Daniel D: 19 articles (04/2015 - 11/2002)|
|6.||Hawley, Angela E: 18 articles (04/2015 - 09/2002)|
|7.||Granger, D Neil: 17 articles (07/2011 - 12/2002)|
|8.||Henke, Peter K: 16 articles (04/2015 - 09/2002)|
|9.||Wrobleski, Shirley K: 15 articles (04/2015 - 11/2002)|
|10.||Schaub, Robert G: 14 articles (04/2015 - 07/2002)|
05/01/1999 - "Animal survival was significantly improved after 75 minutes of total hepatic ischemia in P-selectin deficient mice when compared with wild-type mice. "
11/01/1995 - "Rolling in the postcapillary venules in SC tissue of P-selectin-deficient mice was significantly lower than that in wild-type mice under the basal conditions and post-ischemia-reperfusion (P < .05), but was not eliminated by the deletion of the P-selectin gene. "
11/15/2002 - "Placebo-blinded administration of the humanized anti-human E- and P-selectin monoclonal antibody (HuEP5C7, 20 mg/kg IV, n=9; placebo, n=9) immediately after the onset of 1 hour of temporary ischemia resulted in trends showing reduced polymorphonuclear leukocyte (PMN) infiltration into ischemic cortex, reduced infarct volumes (by 41%), improved neurological score (by 35%), and improved ability to self-care (by 39%). "
07/01/1999 - "P-selectin inhibition prevents early neutrophil activation but provides only modest protection against myocardial injury in dogs with ischemia and forty-eight hours reperfusion."
10/01/1995 - "Survival improved from 15 percent for the rats in the ischemia control group to 55 percent for those in the group receiving anti-P-selectin antibody given 30 minutes before reperfusion (p < 0.05). "
01/01/2004 - "In addition, treatment with anti-P-selectin antibody to reduce the neutrophil-mediated reperfusion damage was equally effective in the absence of C3. "
09/01/1999 - "Is anti-P-selectin therapy effective in hepatic ischemia-reperfusion injury because it inhibits neutrophil recruitment?"
08/01/2010 - "Our study demonstrates that PCI induces temporal changes of P-selectin, Mg, and CK-MB, which may be involved in restenosis and ischemia-reperfusion injury. "
01/01/2005 - "The purpose of this study was to define the kinetic changes in expression of P-selectin on myocardial vessels in a model of global ischemia-reperfusion injury. "
09/01/1999 - "In this study, we hypothesized that P-selectin on platelets may enhance neutrophil endothelial adherence and this may play a role in neutrophil-mediated reperfusion injury. "
04/01/2015 - "Addition of P-selectin to models containing traditional PAD risk factors and markers of inflammation/coagulation significantly improved the net reclassification for ABI progression (p = 0.03), but was only marginally significant for incident PAD (p = 0.06). "
06/15/1996 - "The demonstration that P-selectin mediates eosinophil but not neutrophil influx suggests that suppressing the function of this adhesion molecule may be beneficial in blocking eosinophil accumulation in pleural inflammation."
08/01/2010 - "This study evaluated platelet P-selectin expression as a biomarker for cutaneous inflammation. "
02/01/2008 - "This study is the first to demonstrate a reduction in MPTFA associated with vein reopening and reduced vein inflammation due to oral P-selectin inhibition in a baboon model of DVT."
08/01/2007 - "Therefore, the aim of the present study was to investigate the differential influence of platelet and endothelial P-selectin on the extent of inflammation in AiA. "
01/01/2015 - "This study shows that EPCs impair platelet aggregation and reduce thrombus formation via a cellular mechanism involving binding to platelet P-selectin. "
01/01/2015 - "In the present study, we assessed the impact of EPCs on thrombus formation and we addressed the implication of P-selectin in this process. "
01/01/2014 - "The aim of this study was to determine whether Gata1(low) mice would develop thrombosis with age and, in this case, the role played by P-selectin in the development of the trait. "
09/01/2011 - "This study demonstrates that the role of platelet P-selectin is not solely adhesive; its binding to PSGL-1 induces platelet activation that enhances platelet aggregation and thrombus formation. "
09/01/2011 - "This study supports (99m)Tc-fucoidan as a relevant imaging agent for in vivo detection of biologic activities associated with P-selectin overexpression, such as arterial thrombus and ischemic memory. "
09/17/2002 - "This mechanism represents an important component explaining the protection against neointimal growth in P-selectin-deficient mice and may represent a novel approach to the treatment of restenosis or atherosclerosis by the administration of chemokine receptor antagonists."
01/01/2009 - "Our results indicate that, compared with controls, selective disruption of E- and P-selectin ligand synthesis resulted in a significant reduction in atherosclerosis. "
05/01/2015 - "P-selectin and subclinical and clinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA)."
06/01/2009 - "We therefore investigated the association of SELP polymorphisms with platelet SELP measures and polymorphisms in the SELPLG gene (selectin P ligand) with lymphocyte, granulocyte, and monocyte SELPLG measures among 1870 participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study. "
03/30/2001 - "In vitro studies show that inflammatory factors, such as P-selectin and MCP-1, which can be upregulated by Ang-II, play an important role in atherogenesis. "
|1.||Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
|3.||Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
|4.||von Willebrand Factor
|6.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|7.||CD40 Ligand (CD40L)
|8.||5- acetylneuraminyl- (2- 3)- galactosyl- (1- 4)- (fucopyranosyl- (1- 3))- N- acetylglucosamine (sialyl Lewis x)
|10.||Messenger RNA (mRNA)
|3.||Transplantation (Transplant Recipients)
|5.||Bone Marrow Transplantation (Transplantation, Bone Marrow)