|1.||Köhler, Ralf: 1 article (01/2014)|
|2.||Sadda, Veeranjaneyulu: 1 article (01/2014)|
|3.||Nielsen, Gorm: 1 article (01/2014)|
|4.||Hedegaard, Elise Røge: 1 article (01/2014)|
|5.||Wandall-Frostholm, Christine: 1 article (01/2014)|
|6.||Skaarup, Lykke Moran: 1 article (01/2014)|
|7.||Mogensen, Susie: 1 article (01/2014)|
|8.||Simonsen, Ulf: 1 article (01/2014)|
|9.||Yamamoto, Takashi: 1 article (08/2013)|
|10.||Pal, Narinder: 1 article (08/2013)|
04/01/1999 - "Using whole-cell current recording, chronic hypoxia decreased the high-amplitude, high-noise, and charybdotoxin-sensitive Ca2+-dependent K+ channels (KCa). "
04/01/1997 - "Effects of charybdotoxin on responses to nitrosovasodilators and hypoxia in the rat lung."
02/07/1997 - "ChTX (20 nM) only increased PtiO2 and decreased carotid chemosensory discharge during hypoxia, indicating vasodilation. "
03/15/1995 - "Hypoxia, anoxia and charybdotoxin all depolarized type I cells. "
01/03/1995 - "However, they lack charybdotoxin-sensitive K+ channels that contribute to resting membrane potential in normoxically reared rats, and this appears to prevent them from depolarizing (and hence triggering Ca2+ influx and neurosecretion) during acute hypoxia."
|2.||Prostatic Neoplasms (Prostate Cancer)
03/16/2000 - "In this study patch-clamp electrophysiology was used to show that both AT2.1 and MatLyLu rat prostate cancer cell lines express high levels of a current identified as FIK, based on the following criteria: activation by elevation of intracellular calcium, voltage independence, potassium selectivity, and block by charybdotoxin (ChTX) and the Stichodactyla helianthus potassium channel neurotoxin (StK). "
|3.||Hypotension (Low Blood Pressure)
04/01/2010 - "Apamin (100 microg/kg) plus charybdotoxin (100 microg/kg) abolished 4alpha-phorbol-12,13-didecanoate-induced hypotension in DR-LS, DR-HS, and DS-LS rats only. "
09/01/2003 - "4. Combined administration of apamin and charybdotoxin, but not each of them, specifically abolished the hypotension, increased GMBF and decreased GMVR caused by the PAR-2 agonists. "
09/01/2003 - "6. Our data suggest involvement of apamin/charybdotoxin-sensitive K+ channels in the PAR-2-triggered hypotension and increased GMBF, predicting a role of EDHF-like factors."
04/01/2005 - "A sodium nitroprusside-induced decrease in MAP was unaffected in the presence of apamin-ChTX, but acetylcholine-evoked hypotension was significantly reduced in both groups. "
07/01/2008 - "In 4-wk-old rabbits treated with l-NAME and Indo, the maximum ACh hypotension was reduced by the potassium channel inhibitors apamin and charybdotoxin to -6.9 +/- 0.9%, by apamin alone to -19.5 +/- 1.4%, and by BW755C to -18.8 +/- 3.5%. "
|4.||Ehrlich Tumor Carcinoma
08/01/1999 - "Leukotriene D4 (LTD4) activates charybdotoxin-sensitive and -insensitive K+ channels in ehrlich ascites tumor cells."
06/15/1992 - "Clotrimazole also inhibited two other charybdotoxin-sensitive Ca(2+)-dependent K+ channels, those of rat thymocytes (IC50 = 0.1-0.2 microM) and of Ehrlich ascites tumor cells (IC50 = 0.5 microM). "
01/01/2000 - "The following volume-sensitive channels are characterized in Ehrlich ascites tumor cells (EATC), (i) a tamoxifen- and AA acid sensitive, outwardly rectifying small anion channel (I(Cl,vol)) with low field anion selectivity (I(-)>Cl(-)) and moderate depolarisation-induced inactivation, (ii) a separate DIDS- and niflumic acid-sensitive organic osmolyte/anion channel (OOC) transporting predominantly taurine, and (iii) a clofilium- and Ba(2+)-sensitive, voltage- and Ca(2+)-insensitive 5 pS K(+) channel (I(K,vol)), resistant to a range of K(+) channel inhibitors including ChTX, clotrimazole, apamin, kaliotoxin, margatoxin, and TEA, and with a pH(o) dependence reminiscent of the two-pore domain background K(+) channels TASK. "
04/01/2003 - "In these cells, a hypotonic shock induced K(+) currents blocked by charybdotoxin in WT, but not in KO, mice. "
08/31/2007 - "Treatment of shock animals with the BK(Ca) inhibitors iberiotoxin and charybdotoxin partially restored vascular membrane potential and vasoreactivity to norepinephrine and blood reinfusion. "
|2.||Nitric Oxide (Nitrogen Monoxide)
|4.||4-Aminopyridine (4 Aminopyridine)
|5.||Potassium Channels (Potassium Channel)
|6.||NG-Nitroarginine Methyl Ester (L-NAME)
|9.||Adenosine Triphosphate (ATP)
|10.||Nitric Oxide Synthase (NO Synthase)