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Myelin Proteolipid Protein

A myelin protein that is the major component of the organic solvent extractable lipoprotein complexes of whole brain. It has been the subject of much study because of its unusual physical properties. It remains soluble in chloroform even after essentially all of its bound lipids have been removed. (From Siegel et al., Basic Neurochemistry, 4th ed, p122)
Also Known As:
Folch-Lees Protein; Folch-PI Proteolipid Protein; Myelin PLP; Folch Lees Protein; Folch PI Proteolipid Protein; PLP, Myelin; Protein, Folch-Lees; Protein, Folch-PI Proteolipid; Protein, Myelin Proteolipid; Proteolipid Protein, Folch-PI; Proteolipid Protein, Myelin
Networked: 134 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Greer, Judith M: 7 articles (01/2020 - 06/2004)
2. Tsunoda, Ikuo: 5 articles (01/2022 - 01/2007)
3. Pender, Michael P: 5 articles (01/2020 - 06/2004)
4. Fujinami, Robert S: 4 articles (07/2014 - 01/2007)
5. Waldner, Hanspeter: 4 articles (02/2013 - 04/2004)
6. Kuchroo, Vijay K: 4 articles (10/2007 - 04/2004)
7. Trifilieff, Elisabeth: 3 articles (01/2020 - 02/2008)
8. Libbey, Jane E: 3 articles (07/2014 - 11/2008)
9. Edgar, Julia M: 3 articles (11/2013 - 07/2004)
10. Reddy, Jayagopala: 3 articles (10/2007 - 07/2004)

Related Diseases

1. Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
2. Demyelinating Diseases (Demyelinating Disease)
3. Multiple Sclerosis
4. Pelizaeus-Merzbacher Disease
5. Infections
05/03/1999 - "Infection with a recombinant vaccinia virus encoding myelin proteolipid protein causes suppression of chronic relapsing-remitting experimental allergic encephalomyelitis."
10/01/2016 - "Nonetheless, the most probable theory is based on molecular mimicry, which suggests that some infections can activate T cells against brain auto-antigens like myelin proteolipid protein (PLP) and initiate the disease cascade. "
07/01/2005 - "Our previous reports showed that the infection of SJL mice with a nonpathogenic variant of Theiler's murine encephalomyelitis virus (TMEV) engineered to express a naturally occurring Haemophilus influenzae-encoded molecular mimic (HI574-586) of an immunodominant self-myelin proteolipid protein epitope (PLP139-151) induced a rapid-onset demyelinating disease associated with the activation of PLP139-151-specific Th1 responses. "
01/01/1995 - "The present study also shows that a restricted infection of oligodendrocytes with CDV down-regulates the transcription of the major myelin genes coding for proteolipid protein, myelin basic protein (MBP) and myelin-associated glycoprotein in a very similar way. "
12/01/2012 - "In a novel animal model of MS, SJL/J mice primed through infection with a recombinant vaccinia virus (VV) encoding myelin proteolipid protein (PLP) (VV(PLP)) were susceptible to a central nervous system (CNS) inflammatory disease following administration of a nonspecific immunostimulant [complete Freund's adjuvant (CFA) plus Bordetella pertussis (BP)]. "

Related Drugs and Biologics

1. Epitopes
2. Antigens
3. Peptides (Polypeptides)
4. Proteins (Proteins, Gene)
5. Autoantigens
6. Myelin-Associated Glycoprotein
7. T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)
8. Fatty Acids (Saturated Fatty Acids)
9. Myelin Basic Protein
10. Myelin-Oligodendrocyte Glycoprotein

Related Therapies and Procedures

1. Surgical Instruments (Clip)
2. Intravenous Injections