|1.||Bach, Leon A: 11 articles (06/2015 - 01/2002)|
|2.||Fu, Ping: 6 articles (10/2013 - 08/2007)|
|3.||Babajko, S: 4 articles (10/2002 - 12/2000)|
|4.||Yang, Zhiyong: 3 articles (01/2014 - 02/2013)|
|5.||Bach, L A: 3 articles (11/2003 - 03/2001)|
|6.||Yu, Jing: 2 articles (01/2014 - 01/2014)|
|7.||Xu, Xuan-Fu: 2 articles (09/2011 - 01/2009)|
|8.||Wang, Xing-Peng: 2 articles (09/2011 - 01/2009)|
|9.||Guo, Chuan-Yong: 2 articles (09/2011 - 01/2009)|
|10.||Xu, Ling: 2 articles (09/2011 - 01/2009)|
03/01/2002 - "This study therefore shows that IGFBP-6 plays a role in neuroblastoma cell growth in vivo and in vitro and that stable overexpression of IGFBP-6 leads to alteration of the initial balance between the IGFBPs."
01/01/2001 - "To study the role of IGFBP-6 in cell growth, we stably IGR-N-91 neuroblastoma cells with a plasmid containing sequences coding for IGFBP-6 under the control of the cytomegalovirus (CMV) promoter. "
10/01/2002 - "Our results therefore show the involvement of IGFBP-6 in neuroblastoma cell growth, both ex vivo in terms of proliferation and in vivo in terms of tumour development."
12/01/2000 - "Since IGFBP-6 secretion is associated with the arrest of proliferation in neuroblastoma cells and is regulated by the combined actions of differentiation factors, we subcloned the proximal promoter of human IGFBP-6 (nt -766/+1) into a pCAT expression vector so as to examine modulation of its transcriptional activity. "
12/01/2000 - "Multi-hormonal regulation of IGFBP-6 expression in human neuroblastoma cells."
02/01/2013 - "The present review briefly summarizes the IGF system in physiology and disease before focusing on recent studies on the regulation and actions of IGFBP-6, and its potential roles in cancer cells. "
06/01/2015 - "IGFBP-6 expression is decreased in a number of cancer cells and it has been postulated to act as a tumour suppressor. "
11/20/2008 - "We concluded that IGFBP-6 is the effector of tumor suppressor activity of SEMA3B in NCI-H1299 cells. "
11/20/2008 - "Identification of IGFBP-6 as an effector of the tumor suppressor activity of SEMA3B."
05/01/1999 - "IGFBP-6 levels in plasma samples derived both from children with acute lymphoblastic leukaemia and from patients with various types of solid neoplasms were generally within the normal range. "
|3.||Colonic Neoplasms (Colon Cancer)
01/01/2002 - "Increased expression of IGFBP-6, which has a high binding affinity for IGF-II, following tRA treatment suggests that the decreased proliferation caused by tRA may result, at least in part, from IGFBP-6-mediated disruption of the IGF-II autocrine loop in these colon cancer cells."
08/03/2007 - "Wild-type and mutant IGFBP-6, as well as IGF-II, induced cell migration in RD rhabdomyosarcoma and LIM 1215 colon cancer cells. "
03/28/2001 - "IGFBP-6 had no effect on basal cell adhesion but completely inhibited the effects of IGF-II. LIM 1215 colon cancer cells are therefore IGF-responsive but IGF-II is not a major autocrine factor for these cells in monolayer, suggesting heterogeneity between colon carcinoma cell lines with respect to the role of the IGF system."
10/01/2004 - "The results of the binding studies are supported by the effects of the IGFBP-6 domains on IGF-induced colon cancer cell proliferation; the N-domain inhibited IGF-II induced proliferation with approximately 20-fold lower potency than IGFBP-6 and it was equipotent in inhibiting IGF-I- and IGF-II-induced proliferation. "
06/01/2005 - "IGFBP-6 inhibits growth of a number of IGF-II-dependent cancers, including rhabdomyosarcoma, neuroblastoma and colon cancer. "
|4.||Endometrial Neoplasms (Endometrial Cancer)
11/01/1994 - "In endometrial cancer tissues, the mean IGFBP-6 mRNA level was similar to that in cycling endometrium during the peri-ovulatory period. "
11/01/1994 - "In the endometrium, IGFBP-1 gene expression is stimulated by progesterone and inhibited by insulin, while IGFBP-1 inhibits the mitogenic action of IGF-I. In this study, we used a quantitative reverse transcriptase polymerase chain reaction (RT-PCR) to investigate IGFBP-1, IGFBP-2, IGFBP-4, IGFBP-5 and IGFBP-6 gene expression in endometrial cancer tissues. "
|5.||Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
|1.||Insulin-Like Growth Factor II (Somatomedin A)
|2.||Insulin-Like Growth Factor I (IGF-1)
|3.||Insulin-Like Growth Factor Binding Protein 4
|4.||Insulin-Like Growth Factor Binding Protein 2
|5.||Insulin-Like Growth Factor Binding Proteins
|6.||Insulin-Like Growth Factor Binding Protein 5
|7.||Insulin-Like Growth Factor Binding Protein 1
|9.||RNA-Directed DNA Polymerase (Reverse Transcriptase)
|2.||Heterologous Transplantation (Xenotransplantation)