Insulin-Like Growth Factor Binding Protein 5

12/01/2013 - "IGFBP-5, in contrast, enhanced both cell-cell and cell-ECM adhesion and also improved wound closure in epithelial cells whereas, in mesenchymal cells, IGFBP-5 decreased adhesion and migration. "
01/01/1999 - "Later in the wounding response, levels of IGF-II decline in the CSF and the wound neuropil, possibly with the aid of increased IGFBP-5 levels that may help to locally sequester and down-regulate IGF-II activity. "
02/15/2013 - "IGF-I enhanced scrape-wound closure in keratinocytes whereas IGFBP-5 inhibited this response. "
02/15/2013 - "Further, the IGF-I to IGFBP-5 ratio is altered in diabetic skin, where wound closure is impaired. "
02/15/2013 - "We investigated whether Gap27 remains effective in augmenting scrape-wound closure in human skin wound models simulating diabetes-induced changes, using culture conditions with raised glucose, insulin and IGFBP-5. "

01/01/2010 - "IGFBP-5 Metabolism Is Disrupted in the Rat Medial Meniscal Tear Model of Osteoarthritis."
11/30/2009 - "MMP-13 and IGFBP-5 are important factors involved in osteoarthritis (OA). "
09/01/2004 - "Increased matrix concentrations of IGFBP-5 in cancellous bone in osteoarthritis."
05/01/1998 - "We conclude that locally produced IGFBPs, in particular IGFBP-5, may play a critical role in the regulation of cartilage matrix degradation in inflammatory and degenerative arthritides."
03/01/2002 - "Inhibition of insulin-like growth factor binding protein 5 proteolysis in articular cartilage and joint fluid results in enhanced concentrations of insulin-like growth factor 1 and is associated with improved osteoarthritis."

10/01/1998 - "Serum starvation provoked (i) apoptosis of granulosa cells within 48 hr, (ii) a marked decrease in cell density, and (iii) a marked increase in the amount of IGFBP-5 associated with cell membranes and with the walls of culture wells, but no change in culture medium. "
10/01/1998 - "The increase in the amount of cell- and wall-associated IGFBP-5 after serum starvation was essentially due to the consecutive decrease in cell density rather than to an increase in cell apoptosis. "
10/01/2006 - "Starvation had no effect on liver IGFBP-2 and IGFBP-6 mRNA abundance, whereas refeeding provoked a peak of IGFBP-2 and IGFBP-6 expression at day 7. In muscle, starvation led to a decrease of the IGFBP-2 mRNA level, which was restored only from day 7. IGFBP-4 mRNA abundance in starved fish was lower than in the controls and refeeding led to a transient upregulation (sevenfold) of IGFBP-4 gene at day 1. IGF-I, IGFBP-5, and IGFBP-related protein 1 (rP1) expression profiles were similar, showing a decrease of expression after starvation, a first peak of expression at day 2, a second peak at day 7, and a return to normal value from day 15. "

01/01/2019 - "Finally, proteomic analysis revealed high secretion of insulin-like growth factor-binding protein 5 by TMSCs, and its expression was critical for the protective effects of TMSCs against HFD-induced glucose intolerance and ER-stress response in pancreatic islets. "

01/01/2020 - "This observation suggests that genetic alterations leading to a decreased level of IGFBP-5 may also contribute to breast cancer. "
01/01/2014 - "We here aimed to determine the association between PIK3CA gene mutations and IGFBP-5 expressions for the first time in breast cancer patients. "
01/01/2014 - "Detection of PIK3CA gene mutations with HRM analysis and association with IGFBP-5 expression levels in breast cancer."
03/15/2012 - "IGFBP-5 expression is a marker of poor outcome in patients with breast cancer. "
03/15/2012 - "To improve the significance of insulin-like growth factor-binding protein 5 (IGFBP-5) as a prognostic and potentially predictive marker in patients with breast cancer. "