CD5 Antigens

Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)

Also Known As:

CD5 Antigen; Leu-1 Antigen; T1 Antigen; Antigen, CD5; Leu 1 Antigen; Antigens, CD5

Networked: 101 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Biological Factors: 2472
- Biomarkers: 240291
  - Differentiation Antigens: 2082
    - T-Lymphocyte Differentiation Antigens: 40
      - CD5 Antigens: 101
        mouse Cd5 protein
    - B-Lymphocyte Differentiation Antigens: 23
      - CD5 Antigens: 101
        mouse Cd5 protein
- Antigens: 143924
  - Surface Antigens: 5813
    - Differentiation Antigens: 2082
      - T-Lymphocyte Differentiation Antigens: 40
        CD5 Antigens: 101
        mouse Cd5 protein
      - B-Lymphocyte Differentiation Antigens: 23
        CD5 Antigens: 101
        mouse Cd5 protein

Experts

1.	Hasegawa, Hideaki: 2 articles (11/2021 - 01/2021)
2.	Inoue, Shinya: 2 articles (11/2021 - 01/2021)
3.	Katahira, Yasuhiro: 2 articles (11/2021 - 01/2021)
4.	Miyazaki, Toru: 2 articles (11/2021 - 01/2021)
5.	Mizoguchi, Izuru: 2 articles (11/2021 - 01/2021)
6.	Orii, Naoko: 2 articles (11/2021 - 01/2021)
7.	Xu, Mingli: 2 articles (11/2021 - 01/2021)
8.	Yoneto, Toshihiko: 2 articles (11/2021 - 01/2021)
9.	Yoshimoto, Takayuki: 2 articles (11/2021 - 01/2021)
10.	Ciccoli, Lucia: 2 articles (03/2017 - 01/2017)

Related Diseases

1.	Neoplasms (Cancer) 08/21/2015 - "In contrast, in a 3'RR-deficient background tumors more often expressed the CD5 antigen (32% vs 12%, p = 0.05) that may serve to control autoimmunity and that is suspected to play a role in leukemic transformation. " 09/01/2009 - "Six cases were confirmed to express CD5 antigen on tumor cells. " 09/01/2002 - "It is a neoplasia of mature looking B-monoclonal lymphocytes co-expressing the CD5 antigen (involving the blood, the bone marrow, the lymph nodes and related organs). " 07/01/2002 - "None of the tumor cells in the 40 cases tested expressed CD5 antigen. " 02/01/1997 - "In this review, we report analyses of VH genes in mature B cell malignancies generally or occasionally bearing CD5 antigen such as B CLL, MCL, SLVL and PLL. "
2.	Lymphoma (Lymphomas) 06/01/1984 - "Cells of chronic lymphoid leukaemia and centrocytic (cleaved-cell) lymphomas frequently express T65 (T 101+ or Leu 1+) antigen which is usually found on normal or neoplastic T lymphocytes. " 11/01/1983 - "Using a frozen section immunoperoxidase staining technique, 125 lymphomas with B-cell differentiation were examined for the presence of Leu-1 antigen. " 05/01/1988 - "Anti-T1 which recognizes the CD5 antigen on most T-cell leukemias and lymphomas was used as a control antibody. " 11/01/1986 - "Additionally, a survey of 248 non-Hodgkin's lymphomas of all types revealed four of 70 patients with B-cell large cell lymphoma (LCL; diffuse histiocytic lymphoma, DHL) that also co-expressed the same Leu-1 antigen. " 11/01/1984 - "An increased frequency of Ig heavy chain class switching and loss of T1 antigen suggest that follicular lymphomas are at a later stage of differentiation than most centrocytic lymphomas. "
3.	B-Cell Lymphoma (Lymphoma, B Cell) 12/01/2004 - "The aim of the present study was to determine whether immunophenotypic differences could be used to distinguish between non-Hodgkin's B cell lymphoma (NHL-B) and the normal B cell subpopulation by assessing the variability in the patterns of expression of some lymphoid antigens (CD5, CD19, FMC7, CD23, CD20, CD79b, CD38, CD22, CD10, sIgkappa, sIglambda, mIgA, mIgG, mIgM, and mIgD) in specimens obtained from patients with NHL-B. " 02/01/2000 - "Assessment of the expression of antigens CD5, CD10 and CD23 can be of value in the differential diagnosis of small B-cell lymphoma. " 10/01/1998 - "We observed CD5 antigen expression in a subset of cases of intravascular large B-cell lymphoma (IVLBL), and we report here five cases. " 10/01/1998 - "Intravascular large B-cell lymphoma: the CD5 antigen is expressed by a subset of cases." 06/01/1996 - "These findings suggest that CD5 antigens may serve as valid markers for the prognosis and clinical features of B-cell lymphomas and that CD5+ B-cell lymphomas with an overall poor prognosis occurs at a relatively high frequency in Japan. "
4.	Thymoma (Thymic Carcinoma) 02/01/2016 - "This study was performed to examine the role of the self-reactive CD5 antigen in thymic carcinoma. "
5.	Ewing Sarcoma (Sarcoma, Ewing) 12/01/2023 - "Additionally, our study disclosed significant differentially expressed proteins in pediatric Ewing's sarcoma, including CD5 antigen-like, clusterin, and dermcidin. "

Related Drugs and Biologics

1.	Antigens
2.	Proteins (Proteins, Gene)
3.	Monoclonal Antibodies
4.	Clusterin
5.	Autoantibodies
6.	Immunoglobulin G (IgG)
7.	dermcidin
8.	Immunoglobulin M (IgM)
9.	Interleukin-23 Subunit p19
10.	Cytokines

Related Therapies and Procedures

1.	Aftercare (After-Treatment)