CD1 Antigens

Glycoproteins expressed on cortical thymocytes and on some dendritic cells and B-cells. Their structure is similar to that of MHC Class I and their function has been postulated as similar also. CD1 antigens are highly specific markers for human LANGERHANS CELLS.

Also Known As:

Networked: 16 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Brenner, Michael B: 2 articles (08/2008 - 01/2003)
2.	Dascher, Christopher C: 2 articles (08/2008 - 01/2003)
3.	Ben Nacef, Ibtissem: 1 article (01/2020)
4.	Khiari, Karima: 1 article (01/2020)
5.	Mekni, Sabrine: 1 article (01/2020)
6.	Mhedhebi, Chedi: 1 article (01/2020)
7.	Nadia, Mchirgui: 1 article (01/2020)
8.	Riahi, Ines: 1 article (01/2020)
9.	Rojbi, Imen: 1 article (01/2020)
10.	Agarwal, Sandeep: 1 article (08/2008)

Related Diseases

1.	Neoplasms (Cancer) 09/01/1989 - "The tumor cells carried the CD3 and CD7 T cell antigens, but were double negative for CD4 and CD8 and also lacked other T cell antigens (CD1, CD2, and CD5). " 04/01/1993 - "The data accumulated from the literature lead to the following conclusions: (i) use of different reagents against the CD surface antigens, different positive/negative cut-off levels, analysis of fresh or frozen cell material and variable sensitivities of the analytical instruments (expression of lymphoid-associated antigens was commonly weaker than myeloid-associated markers) seriously influence the results; (ii) most antigens (CD1, CD2, CD3, CD5, CD8, CD10, CD19, CD20, CD21, CD22) were expressed on less than 10% of AML cases; (iii) the CD4 and CD7 antigens, also found on normal monocytic and immature myeloid progenitor cells, were detected in 24% and 15% of AML cases, and their expression correlated with FAB M4/M5 and M1/M2 morphology, respectively; (iv) differences between pediatric and adult Ly+AML were restricted to CD4 and CD19 expression being detected more often in childhood cases; (v) there is no cytogenetic anomaly specific for Ly+AML; anomalies exclusively associated with lymphoid malignancies were not seen; aberrations involving 11q23, 14q32, and the 9;22 translocation seem to be increased; (vi) in most studies, expression of lymphoid-associated antigens (with the exception of CD7) on AML blasts lacked prognostic significance; CD7+AML appears to be a particular subset of malignant myeloid progenitors. "
2.	Subacute Thyroiditis (Thyroiditis, De Quervain) 01/01/2020 - "Histological study showed a granulomatous thyroiditis, and the immunohistochemistry study revealed a strong positivity of histiocytes for the CD1 antigen and for the S100 protein. "
3.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/01/2003 - "Upregulation of group 1 CD1 antigen presenting molecules in guinea pigs with experimental autoimmune encephalomyelitis: an immunohistochemical study."
4.	Infections 05/01/1989 - "We have studied the expression of CD1 antigens on peripheral blood mononuclear cells (PBMC) from acute hepatitis B patients in order to analyse a possible role for CD1 antigens in hepatitis B virus (HBV) infection. " 08/12/2008 - "In contrast, CD1 antigen presentation occurs in the face of Mtb infection and rapid DC maturation because a pool of CD1 molecules remains available on the phagolysosome membrane that is able to acquire lipid antigens and deliver them to the plasma membrane."
5.	Atopic Dermatitis (Atopic Eczema) 10/01/1988 - "Associated expression of CD1 antigen and Fc receptor for IgE on epidermal Langerhans cells from patients with atopic dermatitis." 08/01/1988 - "Epidermal cell suspensions from the skin of seven patients with atopic dermatitis (AD) and seven healthy non-atopic controls were investigated for the presence of surface HLA-DR and CD1 antigen, and IgE using indirect and double-staining immunofluorescence techniques. "

Related Drugs and Biologics

1.	Antigens
2.	Surface Antigens (Surface Antigen)
3.	CD7 Antigens
4.	S100 Proteins (S 100 Protein)
5.	Indicators and Reagents (Reagents)
6.	Monoclonal Antibodies
7.	CD8 Antigens
8.	Immunoglobulin E (IgE)
9.	HLA-DR Antigens (HLA-DR)
10.	Suspensions