Muscle Weakness

A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)

Also Known As:

Networked: 4747 relevant articles (281 outcomes, 228 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Neoplasms (Cancer)
3.	Ophthalmoplegia (External Ophthalmoplegia)
4.	Fatigue
5.	Myositis (Idiopathic Inflammatory Myopathies)

Experts

1.	Nishino, Ichizo: 27 articles (08/2022 - 05/2007)
2.	Granzier, Henk: 17 articles (01/2020 - 02/2003)
3.	Ottenheijm, Coen A C: 16 articles (01/2021 - 07/2009)
4.	Westerblad, Håkan: 15 articles (01/2021 - 08/2002)
5.	Katsuno, Masahisa: 14 articles (08/2022 - 06/2006)
6.	Larsson, Lars: 13 articles (01/2022 - 06/2007)
7.	Lochmüller, Hanns: 13 articles (01/2022 - 09/2006)
8.	Beggs, Alan H: 12 articles (01/2022 - 07/2009)
9.	Straub, Volker: 12 articles (10/2021 - 08/2007)
10.	Sobue, Gen: 12 articles (03/2018 - 06/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Muscle Weakness:

1.	Intravenous Immunoglobulins (IVIG)FDA Link 01/01/2016 - "The initial high-dose intravenous immunoglobulin treatment significantly improved left upper limb muscle weakness. " 10/27/2011 - "One week after administration of intravenous immunoglobulin, a significant improvement was noted in his muscular weakness. " 01/01/2022 - "Intravenous immunoglobulin was administered; thereby, the muscle weakness gradually improved, and the patient returned to work. " 01/01/2021 - "Intravenous immunoglobulin treatment improved muscle weakness and blurred vision, which was not a complaint when he was first seen. " 03/15/2019 - "The patient's muscle weakness gradually improved after IVIg. "
2.	Prednisolone (Predate)FDA LinkGeneric 06/03/2020 - "After she achieved remission with improvement of muscle weakness and reduction of serum CK level to a normal level, the dose of oral prednisolone was gradually tapered to 12.5 mg/day without relapse for 3 months. " 07/01/2002 - "The patient was treated with prednisolone, 60 mg/day, which completely cured his muscle weakness and difficulty in walking, and sensory disturbance was gradually alleviated. " 11/01/2001 - "Oral prednisolone (1-2 mg/kg/day) was given in 6 cases and the muscle weakness improved. " 05/01/2000 - "With oral prednisolone administration, muscle weakness and other clinical features improved gradually. " 08/01/1992 - "Treatment with prednisolone improved muscular weakness and the slow NCV. "
3.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/2023 - "We then introduced oral corticosteroids, which improved her muscle weakness. " 02/28/2006 - "Muscle weakness improved considerably with an increased dose of corticosteroid; after 6 months the patient recovered completely." 01/01/1988 - "Forty-two corticosteroid treated episodes of proximal muscle weakness associated with CK elevations formed the final study group. " 01/01/2023 - "Our findings indicate that pediatric IMNM often causes severe muscle weakness and is refractory to corticosteroids alone. " 01/01/2022 - "Corticosteroid treatment triggered proximal lower limb muscular weakness, and no full muscular strength recovery was observed after corticosteroid withdrawal. "
4.	SteroidsIBA 02/26/2021 - "While the patient was on steroids, her muscle weakness and CPK level gradually improved. " 10/01/2019 - "The patient's muscle weakness, CPK, and liver functions gradually improved, and he was eventually discharged on oral steroids. " 01/01/2019 - "Four patients had muscle weakness, but three of them had normal serum CK levels that responded well to systemic steroids. " 04/01/2001 - "The muscular weakness and the cervical legion in MRI improved two weeks after steroid treatment. " 06/01/2022 - "Muscle weakness was not associated with steroid dose, but was significantly associated with depression (P < 0.0001) and anxiety (P = 0.0009). "
5.	Creatine Kinase (Creatine Phosphokinase)IBA 09/15/2008 - "They also had generalized muscle weakness during infancy and early childhood associated with a nearly fivefold increase in serum creatine kinase (CK) levels, but with normal muscle biopsy and electrophysiologic studies. " 01/24/2023 - "All anti-KS positive patients had no clinical muscle weakness or serum creatine kinase elevation; 8/16 patients (50%) had sicca symptoms at a significantly high frequency compared with anti-Jo-1 positive patients (50% vs. 11%, P=0.01). " 01/01/2023 - "At the age of 11 months, significantly increased levels of creatine kinase were noted, accompanied by mild muscle weakness. " 01/01/2023 - "Proximal muscle weakness (58 patients) was the most common sign reported at testing; elevated creatine kinase (29 patients) was the most common laboratory result. " 01/01/2023 - "After the fourth cycle of PGH, the patient presented with muscle weakness and creatine kinase levels of up to 6755 U/L. "
6.	Vitamin DFDA LinkGeneric 11/01/2017 - "Vitamin D levels measured by radioimmunoassay (RIA) in all eligible patients and individuals included in the study were those with hypovitaminosis D (<30ng/dl) and proximal muscle weakness. " 01/01/2023 - "It is important to understand whether variation in vitamin D status causally influences muscle strength to elucidate whether supplementation may help prevent/treat muscle weakness. " 01/01/2023 - "Similarly, muscle weakness, often indicated by low grip strength, is another public health concern; however, the vitamin D-grip strength relationship is equivocal. " 01/01/2022 - "Vitamin D insufficiency contributes to muscle weakness and a higher risk of falls in older adults. " 01/01/2021 - "Regarding epidemiological studies, the role of vitamin D in musculoskeletal functionality (muscle weakness and physical performance) among elderly people is still controversial. "
7.	MethylprednisoloneFDA LinkGeneric 01/01/2017 - "The patient was initially treated with intravenous methylprednisolone with slight improvement in muscle weakness. " 01/01/2009 - "He was treated with high dose methylprednisolone, which caused severe aggravation of muscle weakness. " 10/01/1998 - "After methylprednisolone pulse therapy, muscle weakness and sensory disturbance improved. " 01/01/2008 - "The muscle weakness and respiratory failure gradually improved after intravenous methylprednisolone administration, and the serum CK level was normalized in several days. " 01/01/2022 - "We report a patient with pemphigus vulgaris on GC-treatment who developed muscle weakness when a cumulative dose of methylprednisolone reached about 20g (14-80mg/d for 2.5 years). "
8.	Riboflavin (Vitamin B2)FDA LinkGeneric 01/01/2021 - "Exercise intolerance and muscle weakness were dramatically improved in all patients treated with riboflavin (100 mg) daily following diagnosis. " 12/02/2020 - "Riboflavin treatment dramatically improved muscle weakness. " 12/26/2018 - "Muscle weakness was quickly improved by riboflavin supplementation, but sensory disturbances required a long-term treatment. " 01/01/2022 - "Among 48 MADD patients with a follow-up of 6.1 years on average, 31 patients were free of muscle weakness recurrence, while 17 patients had episodes of slight muscle weakness upon riboflavin withdrawal, but recovered after retaking a small-dose of riboflavin for a short-term. " 01/01/2022 - "We showed that fluctuating proximal muscle weakness, exercise intolerance and dramatic responsiveness to riboflavin treatment were essential clinical features for all 110 MADD patients. "
9.	AntibodiesIBA 01/01/1987 - "However, some patients with severe muscle weakness had low titers of antibodies, and some patients in remission or with only ocular manifestations had high titers. " 08/01/2023 - "Autoimmune antibodies are formed against postsynaptic neuromuscular junctions in MG, interrupting neuromuscular transmission and causing variable muscle weakness and tiredness. " 07/01/2023 - "Neonatal myasthenia is a transient condition with muscle weakness in the newborn caused by mother's muscle antibodies. " 07/01/2022 - "These antibodies damage the postsynaptic membrane of the neuromuscular junction and cause muscle weakness by depleting AChRs and thus impairing synaptic transmission. " 03/31/2020 - "Although patients with anti-OJ antibodies showed severe muscle weakness, the clinical presentations defined by anti-ARS antibodies were relatively homogeneous. "
10.	EnzymesIBA 12/01/1989 - "Despite the fact she became euthyroid with the treatment, muscle weakness as well as elevated concentrations of muscle enzymes were not improved. " 04/01/2003 - "Despite our reduced number of study samples, our study also suggests a relationship between severe muscle weakness and high seric muscle enzymes." 08/01/2001 - "The amyopathic state is defined by a lack of muscle weakness and through diagnostic tests, including serum muscle enzymes, electromyogram studies, and muscle biopsies, that are usually normal or show only minimal abnormalities. " 06/01/2022 - "She had muscle weakness of Medical Research Council (MRC) grade 3/5 involving the shoulders and pelvic girdle with elevated muscle enzymes. " 01/01/2022 - "We evaluated 205 patients with proximal muscle weakness or high muscle enzymes, who referred to the nailfold capillaroscopy clinic from April 2010 to October 2021. "

Therapies and Procedures

1.	Therapeutics 05/01/1998 - "After 5 times of immunoabsorption therapy, the muscle weakness improved dramatically; she was extubated 16 days after the institution of the therapy and walked without assistance on the 41st day. " 09/16/2022 - "Restaging scans 30 d postCAR-T therapy demonstrated a complete remission, and the symptoms of muscle weakness improved through rehabilitation. " 12/01/2005 - "After six weeks of therapy, biohumoral remission of both diseases was achieved, while complete recovery from muscle weakness was accomplished after four months." 12/01/2002 - "During the 6 courses of the therapy, muscle weakness was markedly improved so that she could hold herself at the sitting position and could have meals by herself. " 01/01/2016 - "The total number of PM/DM cases was approximately 17,000, and the female/male sex ratio was 2.7:1. Almost all patients improved as a result of therapy, but many suffered from sequelae such as muscle weakness. "
2.	Plasmapheresis 07/01/1999 - "Therapeutic trial of plasmapheresis was effective for her muscle weakness. " 06/15/2003 - "Muscle weakness responded well to double-filtration plasmapheresis (DFPP) followed by i.v.Ig, but relapsed 45 days after the initial treatment. " 01/01/1991 - "Subgrouping of patients according to severity of disease, as measured by disability or muscular weakness, or response to plasmapheresis treatment, also failed to reveal significant associations. " 09/01/2005 - "Late-onset narcolepsy presenting as rapidly progressing muscle weakness: response to plasmapheresis." 10/01/2001 - "We performed plasmapheresis four times, which improved her level of consciousness, hyperesthesia, external ophthalmoplegia and muscle weakness, and led to the normalization of brain and spinal cord MRI. "
3.	Drug Therapy (Chemotherapy) 05/01/2003 - "After the second course of chemotherapy, the serum level of antivoltage-gated Ca2+ channel (VGCC) antibody decreased from 190 pg/ml to 120 pg/ml. Marked improvement of the muscle weakness was recognized only after 3 courses of chemotherapy. " 12/01/2022 - "Chemotherapy-induced loss of bone can cause muscle weakness through both changes in endocrine signaling and mechanical loading between muscle and bone. " 08/01/2022 - "Although the patient underwent chemotherapy, she gradually developed muscle weakness in the upper limbs and sensory disturbances of the trunk and limbs. " 07/12/2016 - "The animals that received chemotherapy exhibited concurrent loss of muscle mass and muscle weakness. " 04/01/2016 - "However, while awaiting for chemotherapy, muscle weakness evolved and rapidly progressed. "
4.	Immunotherapy 06/01/2012 - "The scleroderma-like skin changes and muscle weakness improved with immunotherapy. " 01/01/2019 - "Our determination was based on the time of onset of muscular weakness, presence of other immunotherapy-mediated adverse events, and the appearance of symptoms in spite of SCLC that had been stabilized on immunotherapy. " 07/27/2018 - "Needle EMG showed myogenic changes with spontaneous activities and muscle weakness thereafter improved without adding further immunotherapies, suggesting that our patient had viral myositis. " 10/01/2018 - "Gastrointestinal, respiratory, and hematologic AEs were more common in patients who received immunotherapy, whereas general and administration-site AEs and other AEs (eg, fatigue, infections, muscular weakness) were more frequent in patients who received targeted therapy. " 07/01/2007 - "Unlike other inflammatory myopathies, sporadic inclusion body myositis causes slowly progressing muscular weakness and atrophy, it has a distinctive pattern of muscle involvement, and is unresponsive to conventional forms of immunotherapy. "
5.	Aftercare (After-Treatment) 03/01/1976 - "In two of the cases a return to the euthyroid state after treatment was associated with marked clinical improvement in muscle weakness. " 07/01/2017 - "Complete resolution of muscle weakness occurred after treatment discontinuation. " 01/01/2013 - "Muscle weakness and fatigability after treatment in the ICU." 12/01/1994 - "End points assessed before and after treatment schedules were neurological disability score; muscle weakness of the neurological disability score; summated compound muscle action potentials of ulnar, median, and peroneal nerves; summated sensory nerve action potentials of ulnar and sural nerves; and vibratory detection threshold of the great toe using CASE IV. Observers were masked as to treatment used. " 07/01/1993 - "Clinical observation of several hundred Ilizarov patients has demonstrated prolonged muscle weakness in the involved limb after treatment. "